Lateral loading tests using reduced reinforced concrete (RC) walls affected by alkali-silica reactions (ASR) and their simulation analyses were performed in order to evaluate the influence of ASR on the structural performance of shear walls that act as seismic resistant members in nuclear power facilities. The state of RC walls was also measured by several techniques to assess applicable monitoring methods during ASR expansion. The transition of the elastic wave velocity of the walls by the ultrasonic method has a good co-relationship with the transition of the static elastic modulus of the cylindrical specimens, indicating that non-destructive testing could capture the degradation trend of concrete due to ASR expansion. The initial stiffness of the ASR specimens became slightly smaller than that without ASR, but the maximum strength remained at the same level with or without ASR. Based on the results of experiments and analyses, a practically appropriate structural performance evaluation method and a monitoring method of ASR affected RC members were proposed.