Effect of multi-ions doping on the properties of carbonated hydroxyapatite bioceramic

Safarzadeh, Marjan; Ramesh, S.; Tan, C.Y.; Chandran, Hari; Noor, Ahmad Fauzi Mohd; Krishnasamy, Sivakumar; Alengaram, U. Johnson

doi:10.1016/j.ceramint.2018.11.003

Cited by 64 publications

(35 citation statements)

References 52 publications

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“…35 These findings (Table 2) obtained with increasing content of doping elements/ions can be considered as an important proof of the integration of foreign ions into the HAP structure causing a slight gradual increase in the a and c values, while the HAP lattice was not disrupted, and is in very good agreement with related data. 35,36,61 FT-IR and FT-Raman spectra confirmed the high phase purity of all synthesized HAP samples, as it was evident also from the XRD patterns.…”

Section: -supporting

confidence: 60%

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<p>Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration</p>

Garbo

Ločs

D’Este

et al. 2020

IJN

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Purpose: Compositional tailoring is gaining more attention in the development of advanced biomimetic nanomaterials. In this study, we aimed to prepare advanced multi-substituted hydroxyapatites (ms-HAPs), which show similarity with the inorganic phase of bones and might have therapeutic potential for bone regeneration. Materials: Novel nano hydroxyapatites substituted simultaneously with divalent cations: Mg 2+ (1.5%), Zn 2+ (0.2%), Sr 2+ (5% and 10%), and Si (0.2%) as orthosilicate (SiO 4 4-) were designed and successfully synthesized for the first time. Methods: The ms-HAPs were obtained via a wet-chemistry precipitation route without the use of surfactants, which is a safe and ecologically friendly method. The composition of synthesized materials was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The materials were characterized by X-ray powder diffraction (XRD), FT-IR and FT-Raman spectroscopy, BET measurements and by imaging techniques using highresolution TEM (HR-TEM), FE-SEM coupled with EDX, and atomic force microscopy (AFM). The ion release was measured in water and in simulated body fluid (SBF). Results: Characterization methods confirmed the presence of the unique phase of pure stoichiometric HAP structure and high compositional purity of all synthesized nanomaterials. The doping elements influenced the crystallite size, the crystallinity, lattice parameters, morphology, particle size and shape, specific surface area, and porosity. Results showed a decrease in both nanoparticle size and crystallinity degree, coupled with an increase in specific surface area of these advanced ms-HAP materials, in comparison with pure stoichiometric HAP. The release of biologically important ions was confirmed in different liquid media, both in static and simulated dynamic conditions. Conclusion: The incorporation of the four substituting elements into the HAP structure is demonstrated. Synthesized nanostructured ms-HAP materials might inherit the in vivo effects of substituting functional elements and properties of hydroxyapatite for bone healing and regeneration. Results revealed a rational tailoring approach for the design of a next generation of bioactive ms-HAPs as promising candidates for bone regeneration.

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Section: -supporting

confidence: 60%

“…Specifically, a wet chemistry precipitation approach was employed 54,60,61 for the simultaneous multi-doping with Mg, Zn, Sr, and Si in HAP structure. The influence of this type of doping on the physical and chemical characteristics of ms-HAPs has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

<p>Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration</p>

Garbo

Ločs

D’Este

et al. 2020

IJN

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“…CHA (Ca 10−x (PO 4 ) 6−x (CO 3 ) x (OH) 2−x with 0 ≤ x ≤ 2), as a bioceramics candidate for bone implants, consist of three types: B-type (the carbonate ion substitutes the phosphate ion), A-type (the carbonate ion substitutes the hydroxyl ion), and AB-type (the carbonate ion covers the phosphate and hydroxyl ions simultaneously). B-type CHA is the most widely used in biomedical applications [13]. Generally, B-type CHA can reabsorb osteoclasts and is highly soluble in apatite lattices in clinical tests [14].…”

Section: Introductionmentioning

confidence: 99%

Carbonated Hydroxyapatite-Based Honeycomb Scaffold Coatings on a Titanium Alloy for Bone Implant Application—Physicochemical and Mechanical Properties Analysis

et al. 2021

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In this work, carbonated hydroxyapatite (CHA) based on abalone mussel shells (Haliotis asinina) is synthesized using the co-precipitation method. The synthesized CHA was mixed with honeycomb (HCB) 40 wt.% for the scaffold fabrication process. CHA and scaffold CHA/HCB 40 wt.% were used for coating a Titanium (Ti) alloy using the electrophoretic deposition dip coating (EP2D) method with immersion times of 10, 20, and 30 min. The synthesized B-type CHA with a stirring time of 45 min could have lower transmittance values and smaller crystallite size. Energy dispersive X-ray spectroscopy (EDS) showed that the Ca/P molar ratio was 1.79. The scaffold CHA/HCB 40 wt.% had macropore size, micropore size, and porosity of 102.02 ± 9.88 μm, 1.08 ± 0.086 μm, and 66.36%, respectively, and therefore it can also be applied in the coating process for bone implant applications due to the potential scaffold for bone growth. Thus, it has the potential for coating on Ti alloy applications. In this study, the compressive strength for all immersion time variations was about 54–83 MPa. The average compression strengths of human cancellous bone were about 0.2–80 MPa. The thickness obtained was in accordance with the thickness parameters required for a coating of 50–200 μm.

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“…Stoichiometric hydroxylapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) is the most similar material to the mineral component of human hard tissues and therefore it is considered the ideal substance for bone defects restorations [25,26,27]. Keeping the same geometry while accepting a big variety of anions and cations is one of the most important structural characteristics of hydroxylapatite [28,29]. Synthetic HAp can also be doped with several metal ions in order to improve its properties, like bioactivity, degradation rate, antibacterial characteristics, luminescence and magnetic properties [30,31,32,33,34].…”

Section: Introductionmentioning

confidence: 99%

Photoluminescent Hydroxylapatite: Eu3+ Doping Effect on Biological Behaviour

et al. 2019

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Luminescent europium-doped hydroxylapatite (EuXHAp) nanomaterials were successfully obtained by co-precipitation method at low temperature. The morphological, structural and optical properties were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR), UV-Vis and photoluminescence (PL) spectroscopy. The cytotoxicity and biocompatibility of EuXHAp were also evaluated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)) assay, oxidative stress assessment and fluorescent microscopy. The results reveal that the Eu3+ has successfully doped the hexagonal lattice of hydroxylapatite. By enhancing the optical features, these EuXHAp materials demonstrated superior efficiency to become fluorescent labelling materials for bioimaging applications.

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Effect of multi-ions doping on the properties of carbonated hydroxyapatite bioceramic

Cited by 64 publications

References 52 publications

<p>Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration</p>

<p>Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration</p>

Carbonated Hydroxyapatite-Based Honeycomb Scaffold Coatings on a Titanium Alloy for Bone Implant Application—Physicochemical and Mechanical Properties Analysis

Photoluminescent Hydroxylapatite: Eu3+ Doping Effect on Biological Behaviour

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