Effect of Mucoadhesive Polymeric Formulation on Corneal Permeation of Fluoroquinolones

Gade, Sudeep Kumar; Shivshetty, Nagaveni; Sharma, Natalia; Bhatnagar, Shubhmita; Garg, Prashant; Venuganti, Venkata Vamsi Krishna

doi:10.1089/jop.2018.0059

Cited by 12 publications

(4 citation statements)

References 29 publications

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“…Included in the category of synthetic polymers are poly(vinyl alcohol) (PVA), polyvinylpyrrolidone (polyvidone) (PVP), polyacrylic acid (Carbopol ® ), poly(ethylene glycol) (PEG), polyacrylamide, and polyurethanes, which are hydrophilic substances with swelling properties in the presence of biological fluids, thus generating hydrogels [ 113 , 115 ]. Two of them, PVA and PVP, are widely used in ophthalmic formulations (contact lenses and artificial cornea) [ 167 , 168 ] due to their optimal biocompatibility, biodegradability, capacity to form films, transparency, proper viscosity, excellent ocular mucosa penetration, and eye contact [ 169 , 170 , 171 ]. Moreover, PVA exhibits an appropriate capacity to blend with other polymers such as collagen to develop a novel matrix for tissue regeneration.…”

Section: Bacterial Cellulose Composites—important Emerging Materials ...mentioning

confidence: 99%

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

et al. 2022

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Nowadays, the development of new eco-friendly and biocompatible materials using ‘green’ technologies represents a significant challenge for the biomedical and pharmaceutical fields to reduce the destructive actions of scientific research on the human body and the environment. Thus, bacterial cellulose (BC) has a central place among these novel tailored biomaterials. BC is a non-pathogenic bacteria-produced polysaccharide with a 3D nanofibrous structure, chemically identical to plant cellulose, but exhibiting greater purity and crystallinity. Bacterial cellulose possesses excellent physicochemical and mechanical properties, adequate capacity to absorb a large quantity of water, non-toxicity, chemical inertness, biocompatibility, biodegradability, proper capacity to form films and to stabilize emulsions, high porosity, and a large surface area. Due to its suitable characteristics, this ecological material can combine with multiple polymers and diverse bioactive agents to develop new materials and composites. Bacterial cellulose alone, and with its mixtures, exhibits numerous applications, including in the food and electronic industries and in the biotechnological and biomedical areas (such as in wound dressing, tissue engineering, dental implants, drug delivery systems, and cell culture). This review presents an overview of the main properties and uses of bacterial cellulose and the latest promising future applications, such as in biological diagnosis, biosensors, personalized regenerative medicine, and nerve and ocular tissue engineering.

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Section: Bacterial Cellulose Composites—important Emerging Materials ...mentioning

confidence: 99%

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

et al. 2022

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“…Nevertheless, formulations with mucoadhesive features (e.g. chitosan-polyvinyl alcohol containing hydrogels [30] and sulfacetamide sodium microspheres [31]) that can interact with the mucin layer are shown to have longer retention time and improved drug absorption into the eye [31][32][33], suggesting the importance of this layer for drug delivery purposes and bioavailability.…”

Section: The Barriers Of the Corneamentioning

confidence: 99%

Challenges and strategies for the delivery of biologics to the cornea

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et al. 2021

Journal of Controlled Release

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“…This observation was in accordance with a swelling-controlled release. Gade et al developed a three-component formulation based on CS, PVA, and PVP for the ocular delivery of fluoroquinolones, namely besifloxacin and levofloxacin [243]. The composition of the optimized hydrogels was 3% PVA/1% PVP/1% CS for besifloxacin and 1% PVA/0.5% PVP/0.5% CS for levofloxacin.…”

Section: Non-ionic Polymersmentioning

confidence: 99%

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.

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Effect of Mucoadhesive Polymeric Formulation on Corneal Permeation of Fluoroquinolones

Abstract: The results of the study show the multicomponent hydrogel formulations of besifloxacin and levofloxacin to have superior corneal permeation with the potential for being used as topical ophthalmic preparations.

Cited by 12 publications

References 29 publications

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

Bacterial Cellulose—A Remarkable Polymer as a Source for Biomaterials Tailoring

Challenges and strategies for the delivery of biologics to the cornea

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

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