Effect of MTTP -493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis

Prata, Thamiris Vaz Gago; Manchiero, Caroline; Dantas, Bianca Peixoto; Nunes, Arielle Karen da Silva; Tengan, Fátima Mitiko; Magri, Mariana Cavalheiro

doi:10.1016/j.clinsp.2022.100094

Cited by 4 publications

(1 citation statement)

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“…The assembly of VLDL accompanies by the function of apoB and MTTP genes, and low expression of hepatic MTTP is reported to associate with the pathogenesis of NAFLD [ 49 ]. Although several MTTP SNPs have been identified, a common polymorphism rs1800591-493 G>T contributes to NAFLD by decreasing the expression of MTTP and impairing the potential ability of this gene to export lipids [ 50 ]. Although Tan et al found no association between NAFLD and the rs1800591 polymorphism of the MTTP gene in a meta-analysis, it is suggested that this polymorphism could be used as a biomarker for early diagnosis of NAFLD [ 51 ].…”

Section: Metabolic-related Genes Influencing Nafldmentioning

confidence: 99%

Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches

Mahmoudi,

Tarzemani,

Aghajanzadeh

et al. 2024

Eur J Med Res

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Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases, affecting more than one-quarter of people worldwide. Hepatic steatosis can progress to more severe forms of NAFLD, including NASH and cirrhosis. It also may develop secondary diseases such as diabetes and cardiovascular disease. Genetic and environmental factors regulate NAFLD incidence and progression, making it a complex disease. The contribution of various environmental risk factors, such as type 2 diabetes, obesity, hyperlipidemia, diet, and sedentary lifestyle, to the exacerbation of liver injury is highly understood. Nevertheless, the underlying mechanisms of genetic variations in the NAFLD occurrence or its deterioration still need to be clarified. Hence, understanding the genetic susceptibility to NAFLD is essential for controlling the course of the disease. The current review discusses genetics’ role in the pathological pathways of NAFLD, including lipid and glucose metabolism, insulin resistance, cellular stresses, and immune responses. Additionally, it explains the role of the genetic components in the induction and progression of NAFLD in lean individuals. Finally, it highlights the utility of genetic knowledge in precision medicine for the early diagnosis and treatment of NAFLD patients.

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Section: Metabolic-related Genes Influencing Nafldmentioning

confidence: 99%