Effect of moxibustion on cardiac remodeling and myocardial function in rats with exercise-induced fatigue

Shen, Zheng-xian; Zhu, Jie; Liang, Yu-lei; Zhang, Zhifang

doi:10.4103/wjtcm.wjtcm_70_20

Cited by 6 publications

(9 citation statements)

References 6 publications

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“…Moreover, the most prominent risk factors for AF development, such as age, sex, increased BMI, hypertension, and HF, have all been related to elevated natriuretic peptide concentrations. Previous studies showed that patients with AF had signifcantly higher CRP levels than the SR group [20], and elevated hs-CRP levels were signifcantly associated with an increased risk of AF [35][36][37]. However, circulating BNP and CRP are known biomarkers for systemic circulation and can be infuenced by many factors, such as HF and acute or chronic infammation.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers for Predicting the Occurrence and Progression of Atrial Fibrillation: Soluble Suppression of Tumorigenicity 2 Protein and Tissue Inhibitor of Matrix Metalloproteinase-1

Sun

Chen

2022

International Journal of Clinical Practice

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Background. Soluble suppression of tumorigenicity 2 protein (sST2) and tissue inhibitor of matrix metalloproteinase (TIMP)-1 are involved in multiple pathogenic pathways, including cardiac remodeling, which is the main pathology of atrial fibrillation (AF). This study aims to investigate the previously unexplored relationship between the serum levels of sST2, TIMP-1, and AF. Methods. This was a prospective cross-sectional study conducted at the Capital Medical University Affiliated Beijing Anzhen Hospital between June 2019 and July 2020, with a total of 359 participants. The clinical characteristics and laboratory results of the patients were compared, and multivariable ordinal logistic regression was used to evaluate the relationship between serum sST2, TIMP-1, and AF. Results. The participants included 110 patients with sinus rhythm (SR), 113 with paroxysmal AF (the paroxysmal AF group), and 136 with persistent AF (the persistent AF group). It was found that the sST2 levels gradually increased in these three groups, from 9.1 (6.7–12.4 pg/ml) in the SR group to 14.0 (10.4–20.8 pg/ml) in the paroxysmal AF group and to 19.0 (13.1–27.8) pg/ml) in the persistent AF group ( p < 0.001 ). The multivariable ordinal logistic regression model for sST2 and TIMP-1 demonstrated that sST2 had an area under the receiver operating characteristic (ROC) curve (AUC) of 0.797 (95% confidence interval (CI) 0.749–0.846, p < 0.001 ) and TIMP-1 had an AUC of 0.795 (95% CI 0.750–0.841, p = 0.000 ). The multivariable ordinal logistic regression model for sST2 and TIMP-1 showed good discrimination between SR and AF, with an AUC of 0.846, and the addition of clinical factors, such as brain natriuretic peptide (BNP), left atrial diameter, age, and gender, to the biomarker model improved the detection of SR and AF (AUC 0.901). Conclusions. In this cohort study, sST2 and TIMP-1 were associated with AF progression, independent of clinical characteristics and biomarkers. Soluble ST2 and TIMP-1 combined with age, elevated N-terminal-pro hormone BNP(NT-BNP), and an enlarged left atrium were able to demonstrate the progression of AF reliably.

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Section: Discussionmentioning

confidence: 99%

Biomarkers for Predicting the Occurrence and Progression of Atrial Fibrillation: Soluble Suppression of Tumorigenicity 2 Protein and Tissue Inhibitor of Matrix Metalloproteinase-1

Sun

Chen

2022

International Journal of Clinical Practice

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“…Finally, 18 studies were included in this review. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] The literature selection process is detailed in Figure 1.…”

Section: Study Selectionmentioning

confidence: 99%

“…As a result, the risk of bias on Item 1 could not be judged for many articles. Baseline similarities were reported 9 studies [19][20][21]23,26,29,[32][33][34] (items 2-4), whereas information about allocation concealment was not reported at all (item 5). Random placement of cages or animals in animal facilities was stated for all studies (items 6, 7).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…Random placement of cages or animals in animal facilities was stated for all studies (items 6, 7). [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] However, 3 studies described blinding animal breeders and researchers (item 8). 24,28,34 As a result, performance bias could not be judged.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

“…21 All other studies were scored with a low risk of bias on these items. Additionally, other sources of bias were not clearly described, and could lead to a high risk of bias (items [18][19][20][21][22]. Overall, the methodological quality of animal experiments is poor in terms of the selection bias, performance bias, detection bias, attrition bias and other potential sources of bias.…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

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Effects of Acupuncture on Cancer Pain in Animal Intervention Studies: A Systematic Review and Quality Assessment

Jiao

Zhang

et al. 2022

Integr Cancer Ther

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Background: Preclinical studies often provide the evidence base for clinical studies. However, the design and reporting of preclinical trial results are inadequate, resulting in poor reproducibility and clinical translatability. We aimed to systematically evaluate the methodology and reporting quality of animal studies of acupuncture for cancer pain. Methods: About 7 databases were searched for animal research articles on acupuncture for cancer pain from the beginning of the database to January 31, 2022. ARRIVE guidelines, STRICTA, and SYRCLE risk of bias tools were used to assess the reporting quality and risk of bias of the selected studies. Results: A total of 18 studies were evaluated. Of the 22 items on the SYRCLE tool, only 6 items had a positive reporting rate of more than 50%. Of the 39 items in the ARRIVE guidelines, 14 were rated excellent, and the least frequently reported checklist items were 7. Out of the 17 STRICTA checklist items analyzed, 10 were considered appropriately reported in more than 80% of the studies, while 4 were correctly reported in less than 20%. Conclusions: Some crucial points in the design, implementation, and reporting of the experiments included in the study were not well developed, which could significantly affect the clarity, reproducibility, and translatability of the experiments. There is a need to fully implement scientific tool guidelines for future experimental studies in order to improve the quality of preclinical studies and facilitate effective translation of their results to the clinic.

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Using terahertz spectroscopy to quantify bioactive flavonoids in Moxa Wool as predictor of rheumatoid arthritis treatment outcomes

Shao,

Zhou,

Wan

et al. 2024

Phytomedicine

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Effect of moxibustion on cardiac remodeling and myocardial function in rats with exercise-induced fatigue

Cited by 6 publications

References 6 publications

Biomarkers for Predicting the Occurrence and Progression of Atrial Fibrillation: Soluble Suppression of Tumorigenicity 2 Protein and Tissue Inhibitor of Matrix Metalloproteinase-1

Biomarkers for Predicting the Occurrence and Progression of Atrial Fibrillation: Soluble Suppression of Tumorigenicity 2 Protein and Tissue Inhibitor of Matrix Metalloproteinase-1

Effects of Acupuncture on Cancer Pain in Animal Intervention Studies: A Systematic Review and Quality Assessment

Using terahertz spectroscopy to quantify bioactive flavonoids in Moxa Wool as predictor of rheumatoid arthritis treatment outcomes

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