Effect of mother-in-law’s tongue leaves (Sansevieria trifasciata) extract’s solvent polarity on anti-diabetic activity through in vitro α-glucosidase enzyme inhibition test

Abstract

Diabetes Mellitus (DM) is a metabolic disease caused by elevated blood glucose levels above normal values (hyperglycemia). Natural ingredients that contain hypoglycemic substances, can become an alternative treatment of DM, i.e. mother-in-law’s tongue leaves (Sansevieria trifasciata), which is known to contain flavonoids, glycosides, alkaloid, and steroids that have anti-diabetic activity. The goal of this research is to obtain mother-in-law’s tongue leaves crude extract which has the highest anti-diabetic activity as an α-glucosidase inhibitor. The result showed that from all solvents used, which is aquadest, 70% ethanol, and 70% ethyl acetate, extracted with 70% ethanol has the highest yield value, which is 12.69%. The percentage of inhibition α-glucosidase was 90.72% at the inhibitor concentration of 4708.71. This shows that the extract with 70% ethanol has the required bioactive compound content to act as the α-glucosidase enzyme inhibitor. Based on the identification of compounds found in the sample mother-in-law's tongue leaves extract with 70% ethanol using Gas Chromatography and Mass Spectrometry (GC-MS), compounds that have anti-diabetic activity is steroids, alkaloids, terpenoids, tocopherol, and flavonoid.

Inhibition of protease activity and anti‐quorum sensing of the potential fraction of ethanolic extract from Sansevieria trifasciata Prain leaves against Pseudomonas aeruginosa

“…Several bioactive compounds from S. trifasciata leaves have been reported. These compounds such as quinolones, 3,4dimethoxybenzoic acid, palmitalde hyde, 1,2benzenedicarboxylic acid, linoleic acid, quinolone, and deltaundecalactone have antibacterial activities (Yumna et al 2018). Researchers developed interest in conducting antibacterial testing of probable refractionated ethanolic extract of S. trifasciata because of these distinct chemical components.…”

Antibacterial Potency of an Active Compound from Sansevieria trifasciata Prain: An Integrated In Vitro and In Silico Study

“…This plant has been traditionally used since ancient times [ 1 ]. Therefore, numerous studies have been conducted to prove its pharmacological effects and determine the chemical constituents of these plants [ 2 , 3 ]. Phytochemical studies showed the presence of trifasciatine C dihydrochalcone derivatives [ 4 ], steroidal saponins such as trifasciatoside A-I [ 5 ], trifasciatosides K-N, 1,2-(dipalmitoyl)-3-O-β-D-galactopyranosylglycerol, aconitic acid, 1-methyl aconitic acid [ 4 ], Neoruscogenin, ruscogenin, sansevierigenin, Luvigenin [ 6 ], homoisflavonoid trifasciatin A-B [ 7 ], pregnane glucoside [ 8 ], alkaloid 1-Acetyl-β-carboline, methyl pyrophaeophorbide A, and oliveramine, and flavonoids such as (2S)-3′, 4′-methylenedioxy-5, 7-dimethoxyflavane, monoterpenes digiprolactone, phenolic methyl gallate, and fatty acid trichosanic acid [ 3 ].…”

The Bioavailability Prediction and Screening Phytochemicals of Sansevieria Trifasciata Leaves Extract

“…bioactive compounds in Sansevieria trifasciata that act as antidiabetics is still limited. The results of the analysis through Gas Chromatography-Mass Spectrophotometry (GC-MS) that has been carried out previously [3], and also LCMS is still new to suspect bioactive substances that act as antidiabetics in Sansevieria trifasciata leaves [4].…”

“…Several studies have shown bioactive analysis through GC-MS and LCMS on species S. rhoxburghiana and S.trifasciata as potential medicinal plants [3,13]. Research in the search for antidiabetic agents continues.…”