Abstract:Introduction: The most commonly encountered morphological preservation artifacts in the histological assessment of breast cancer include retraction of tumour cell clusters from the stroma, cytoplasmic retraction and alterations in nuclear morphology. This study intended to assess how these artifacts affect the quality of immunohistochemical (IHC) staining for ER and Her-2. nd rd Methods: For this retrospective study, 120 cases of consecutive breast cancers reported by the 2 and 3 authors during 2009 to 2010 we… Show more
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