Effect of Moringa olefiera on neurotoxicity induced by sodium fluoride in rats

Abstract

This study was carried out to evaluate the detoxifying effects of aqueous extract of Moringa Oleifera on sodium fluoride-induced neurotoxicity in male Wister rats. Design: Randomized controlled study. Animals: Forty rats Procedures: Rats were allocated into four equal groups (10 each). Basically, each group received the same basal diet for 30 days. The first group was not received additional treatment (negative control). However, the second group received 20 mg/kg b.wt sodium fluoride daily (positive control), the third group received sodium fluoride at a dose of 20 mg/kg b.wt and Moringa Oleifera at 300 mg/kg daily, and the fourth group received sodium fluoride at a dose of 20 mg/kg b.wt and Moringa Oleifera 500 mg/kg daily using a stomach tube. Results: Dopamine and serotonin were significantly increased in Moringa Oleifera treated rats at 300 and 500 mg/kg in comparison with rats treated with sodium fluoride, but the higher dose of M. Oleifera achieved the best result (1.23±0.13 vs. 0.31±0.013) and (2.95±0.019 vs. 0.91±0.016) respectively. TAC, SOD, catalase were significantly increased in Moringa Oleifera treated rats at 300 and 500 mg/kg in comparison with rats treated with sodium fluoride, versed with MDA significantly decreased in Moringa Oleifera treated rats Also, to improve the anatomical structure of the disease in the brain reduces heavy bleeding and neurodegenerative changes, and maintains normal nerve cells, improves antioxidant ability as a whole. Conclusion and clinical relevance:Collectively, our results indicate that Moringa Oleifera watery extract has a detoxifying effect on NaF induced neurotoxicity via improving neurotransmitters andantioxidant activity.

Moringa oleifera leaf extract ameliorates cisplatin evoked neurotoxicity in male wistar rats

“…Anti-inflammatory and antioxidant potential of isolated plants have been demonstrated beneficial effects against neuritis, anxiety and spasm. 10,16 Many literature studies explored that the recurrence of oxidative stress, lipid peroxidation and mitochondrial dysfunction in CIS-evoked neurotoxicity. The administration of CIS causes cytotoxicity by generating ROS, lead to an elevation in MDA and fall in the activity of antioxidant defense enzymes like SOD, catalase, as well as a change in the concentrations of nonenzymatic components of GSH that prevent or protect against LPO in the brain tissues.…”

“…So, histopathological investigation revealed that inhibition of neurodegeneration in the MOLE treated rats compared with of the CIS treated rats. 16,22…”