Effect of Morinda citrifolia (Noni) Fruit Juice on Antioxidant, Hematological and Biochemical Parameters in N-Methyl-N-Nitrosourea(NMU) Induced Mammary Carcinogenesis in Sprague-Dawley Rats

Saminathan, Mani; Bahal, Ram; Dhama, Kuldeep; Jangir, Babu Lal; Suresh, Subramaniyam; Ranganath, G.J.; Inbaraj, Sophia; Karuppanas, Kuppusamy; Barathiraj, Singaram; Gopalakris, Arumugam

doi:10.3923/ijp.2014.109.119

Cited by 12 publications

(3 citation statements)

References 37 publications

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“…Commonly used chemical carcinogen-based models are N-Methyl-N-Nitrosourea (NMU), 7, 12dimethylbenzanthracene (DMBA), methylchloranthracene (MCA), diethylnitrosoamine (DEN) and azoxymethane (AOM) [6]. DMBA and NMU induced rat mammary carcinoma models are widely used to study the human breast cancer [7].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and histopathological evaluation of an in vivo model of breast cancer

Sharma¹,

Negi²,

Bal³

et al. 2021

GSC Biol. and Pharm. Sci.

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Though, the clinical management of breast cancer has improved significantly over the past 30 years, it still remains the leading cause of cancer-related female death worldwide. Prevention is the fundamental issue in breast cancer control, for which identification markers in terms of initiation and promotion are necessary. To understand this, an animal model which can recapitulate the early symptoms of breast cancer development and progression is required. Present study is an attempt to develop a convenient and economical in-vivo animal model of breast cancer suitable to conduct such study. Female Wistar and SD rats were injected with different doses and routes of administration of 7, 12-Dihydroxymethylbenz (a) anthracene (DMBA). Animals were observed for the presence of visible/palpable tumours in mammary glands. Various parameters (Tumor morphology, oxidative stress and histopathological studies were studied in different tissues (mammary, lungs, kidney, liver) after the appearance of mammary tumours in rats. After 14 weeks all the animals developed breast carcinomas. The results of this study revealed a significant difference in oxidative stress parameters between DMBA treated and control groups and these alterations were strain dependent. The H&E staining of mice mammary tissue showed development of metaplastic triple negative breast cancer. Immunohistochemistry observation confirmed the triple negative nature of mammary tumours developed in the mice. Data confirmed that DMBA can be used as breast cancer initiator and present model can be further exploited to screen potential anti-breast cancer compounds in vivo.

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Section: Introductionmentioning

confidence: 99%

Biochemical and histopathological evaluation of an in vivo model of breast cancer

Sharma¹,

Negi²,

Bal³

et al. 2021

GSC Biol. and Pharm. Sci.

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“…M.citrifolia inhibited the growth of breast, colorectal and lung cancer cells. 84,85 Saminathan et al, 86 reported that noni juice treatment increased the levels of antioxidant enzymes and significantly decreased lipid peroxidation levels in the N-methyl-N-nitrosourea(NMU) treated group as compared to the NMU alone treated group. Uma et al, 87 evaluated noni juice's neuroprotective effects on scopolamine-induced memory loss rats.…”

Section: Morinda Citrifolia Lmentioning

confidence: 99%

Indian Medicinal Plants with Multiple Pharmacological Efficacies: A Comprehensive Review

Harish,

Sivasankaran,

Manoharan

2024

J. Drug Delivery Ther.

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Medicinal herbs have long been utilized by numerous countries, ethnic groups, and cultures across the globe to treat various diseases since ancient times. A variety of phytochemicals, including alkaloids, tannins, carotenoids, proteins, chlorophyll, phytosterols, glycosides, phenols, flavonoids, and diterpenes, as well as minerals, vitamins and other crucial nutrients are abundantly found in medicinal plants. Medicinal plants and herbs are very useful for developing new drugs due to their potent pharmacological properties. Traditional Indian system of medicines consists of a wealth of information on medicinal plants, which contributed to developing therapies for communicable and non-communicable diseases. The present review summarizes the pharmacological characteristics such as antimicrobial, antioxidant, antiinflammatory, antidiabetic, anticancer, antiulcer, hepatoprotective and cardioprotective effects of some valuable medicinal plants and herbs. Keywords: Indian medicinal plants; Bioactive constituents; Pharmacological efficacies.

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“…Ten studies 24,[63][64][65][66][67][68][69][70][71] reported on the safety and toxicological assessment of M. citrifolia. Table 9 describes the safety implications of Noni investigated on animal toxicity, chronic, and subchronic toxicities as well as cell toxicity studies.…”

Section: Safety and Toxicity Assessmentmentioning

confidence: 99%

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

et al. 2022

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Cancer is a major cause of morbidity and mortality worldwide and therefore there has been interest in discovering the phytoconstituents of medicinal plants exhibiting anticancer activities. Morinda citrifolia L., commonly known as Noni, has shown anticancer properties in in vitro, in vivo, and in clinical studies. A systematic review was conducted to collate scientific evidence on the anticancer properties of M. citrifolia using pre-determined keywords on 5 electronic databases: MEDLINE, CENTRAL, LILACS, Web of Science, and EBSCOHost. A total of 51 clinical and preclinical studies comprising 41 efficacy and 10 safety studies were included in this review. Our findings showed that M. citrifolia demonstrated various anticancer properties in different cancer models, via multiple mechanisms including antitumor, antiproliferative, pro-apoptotic, antiangiogenesis, antimigratory, anti-inflammatory, and immunomodulatory activities. M. citrifolia is deemed to be a potentially valuable medicinal plant in the treatment of cancer through its many intrinsic pathways. More well-designed and reported preclinical efficacy and safety studies are needed to allow for better translation into future clinical studies which could further substantiate the role of M. citriflolia in cancer treatment.

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Effect of Morinda citrifolia (Noni) Fruit Juice on Antioxidant, Hematological and Biochemical Parameters in N-Methyl-N-Nitrosourea(NMU) Induced Mammary Carcinogenesis in Sprague-Dawley Rats

Cited by 12 publications

References 37 publications

Biochemical and histopathological evaluation of an in vivo model of breast cancer

Biochemical and histopathological evaluation of an in vivo model of breast cancer

Indian Medicinal Plants with Multiple Pharmacological Efficacies: A Comprehensive Review

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent

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