Effect of Montelukast on Single-Dose Theophylline Pharmacokinetics

Malmström, Kerstin; Schwartz, Jules I.; Reiss, Theodore F.; Sullivan, Timothy J.; Reese, James H.; Jáuregui, Luis; Miller, Kelly R.; Scott, M B; Shingo, Sumiko; Peszek, Iza; Larson, Patrick; Ebel, David L.; Hunt, Thomas L.; Huhn, Richard D.; Bachmann, Kenneth

doi:10.1097/00045391-199805000-00010

Cited by 18 publications

(9 citation statements)

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“…[63] In adults, the pharmacokinetics of theophylline, [64] the (R)-or (S)-enantiomer of warfarin, [65] digoxin, [57,66] terfenadine [67] or fexofenadine [57] were unaltered by concomitant montelukast administration. The C max and AUC ∞ of a single 10mg oral dose of montelukast were reduced by 37.5 and 21%, respectively, in healthy, adult volunteers who also received phenobarbital (phenobarbitone) [100 mg/day for 14 days], but dosage adjustments are not recommended.…”

Section: Studies In Humansmentioning

confidence: 99%

Montelukast

Muijsers¹,

Noble²

2002

Pediatric Drugs

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Oral montelukast has shown efficacy as a preventive treatment for asthma during clinical trials in children aged 2 to 14 years. The drug offers benefits over more standard therapies such as inhaled sodium cromoglycate and nedocromil in terms of compliance and convenience. In addition, the drug offers significant benefits when added to inhaled corticosteroids (according to secondary endpoints). Montelukast offers an effective, well tolerated and convenient treatment option for children with asthma.

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Section: Studies In Humansmentioning

confidence: 99%

Montelukast

Muijsers¹,

Noble²

2002

Pediatric Drugs

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“…In a 12-week study, montelukast demonstrated a faster onset of action and a greater initial effect than beclomethasone. 29 While both drugs significantly improved FEV 1 , PEFR, the number of asthma control days, and the number of asthma exacerbation days, the overall average effect was greater for beclomethasone compared with montelukast. Figure 4 shows the percentage of patients that responded for each increment of FEV 1 change; 42% of the montelukast recipients and 50% of beclomethasone recipients had an improvement in FEV 1 of at least 11% from baseline.…”

Section: L I N I C a L S T U D I E S I N A D U L T Smentioning

confidence: 93%

Use of oral montelukast in the treatment of asthma

et al. 2001

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“…However, when investigated in vivo, using the CYP2C8-dependent substrate, pioglitazone, this inhibitory potential of montelukast was not realized, with negligible impact on the pharmacokinetics of the drug (Jaakkola et al, 2006). There also does not appear to be any inhibitory effects in vivo on CYP1A2, as assessed by theophylline metabolism (Malmstrom et al, 1998), or CYP2C9, as assessed by warfarin metabolism (Van Hecken et al, 1999), at least not at clinical doses of montelukast.…”

Section: Metabolism-based Interactions Involving Drugs Used To Treat mentioning

confidence: 99%

Drug interactions

Boobis

Watelet

Whomsley³

et al. 2009

Drug Metabolism Reviews

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Drugs for allergy are often taken in combination with other drugs, either to treat allergy or other conditions. In common with many pharmaceuticals, most such drugs are subject to metabolism by P450 enzymes and to transmembrane transport. This gives rise to considerable potential for drug-drug interactions, to which must be added consideration of drug-diet interactions. The potential for metabolism-based drug interactions is increasingly being taken into account during drug development, using a variety of in silico and in vitro approaches. Prediction of transporter-based interactions is not as advanced. The clinical importance of a drug interaction will depend upon a number of factors, and it is important to address concerns quantitatively, taking into account the therapeutic index of the compound.

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Effect of Montelukast on Single-Dose Theophylline Pharmacokinetics

Cited by 18 publications

References 0 publications

Montelukast

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Use of oral montelukast in the treatment of asthma

Drug interactions

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