Effect of monosodium glutamate on oxidative stress and apoptosis in rat thymus

Pavlović, Voja; Pavlović, Dušica; Kocić, Gordana; Sokolović, Dušan; Jevtović-Stoimenov, Tatjana; Cekić, Sonja; Veličković, Dragana

doi:10.1007/s11010-007-9469-7

Cited by 57 publications

(42 citation statements)

References 41 publications

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“…However, another study showed that vitamin C can elevate intracellular glutathione levels through the pentose phosphate pathway [28], although it may not be the main protective mechanism of vitamin C during oxidative stress. Indeed, other studies have proposed that reactive oxygen species sensitize T cells to apoptosis by decreasing Bcl-2 protein expression [29,30]. Such observations are consistent with findings that ascorbic acid prevents apoptosis by upregulating the Bcl-2 protein expression in various cell types [31] and also those of our recent report in rat thymocytes [32].…”

Section: Discussionsupporting

confidence: 92%

The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes

et al. 2010

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AbstractAlthough, the antiarrhythmic effect of amiodarone (AMD) is well characterized, the mechanism of its toxicity on extracardiac tissues is still poorly understood. Several antioxidants have been shown to prevent AMD-induced toxicity by antioxidant and/or non-antioxidant mechanisms. In the current study, we evaluated the possible protective effect, in vitro, of vitamin C on AMD-induced toxicity in rat thymocytes. Rat thymocytes were cultured with increasing AMD concentrations (1–20 μM) with or without vitamin C (1000 μg/ml), for 24 hours. Cells treatment with AMD resulted in a concentration-dependent increase of hypodiploid cells and a significant decrease in cellular glutathione content. Vitamin C combined with AMD significantly decreased the proportion of hypodiploid cells and markedly increased the cellular glutathione content, compared with AMD treatment alone. These results suggest that treatment with vitamin C may prevent AMD-induced toxicity in rat thymocytes by restoring cellular glutathione content.

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Section: Discussionsupporting

confidence: 92%

The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes

et al. 2010

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“…Liver includes to the organs that is vulnerable to the free radical (Pavlovic et al, 2007). The damages of liver caused by cigarette smoke can be recognized by check-up enzyme category transaminase, Aspartate Aminotransferase (AST) enzyme or well-known as Glutamate Oxaloacetate Transaminase (GOT) and Alanine Aminotransferase (ALT) enzyme or well-known as Glutamate Pyruvate Transaminase (GPT).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Red Fruit Oil (Pandanus conoideus) to the Histophysiology of Rat (Rattus norvegicus) Liver Exposed to Cigarette Smoke

2018

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Free radicals in cigarette smoke may interfere the balanced of body molecules and cause the damage of hepatic cells. This issues may be prevented by using red fruit oil (Pandanus conoideus L) due to its antioxidant content. This study aimed to evaluate the structure and physiological conditions of liver when the red fruit oil given to the rat that exposed by cigarette smoke. This study carried out for 35 days with female white rats as the sample. The samples were 20 female white rats divided into four groups: P0 (negative control), P1 (positive control), P2 (exposed by cigarette smoke with administration of red fruit oil 0,1 ml/BB), P3 (exposed by cigarette smoke with administration of red fruit oil 0,2 ml/weight). The data of ALT, AST, cell diameter, and hepatic weight were analyzed by using analysis of variants (ANOVA). The results showed that administration of red fruit oil containing antioxidants can reduce levels of ALT, AST, hepatocyte diameter, and increase liver weight, although the difference is not significant compared to the control group and does not affect the eating and drinking behavior so as not to affect the body's metabolism. The conclusion of red fruit oil can reduce ALT, AST, hepatocyte diameter and increase hepatic weight due to exposure to cigarette smoke, although the difference is not significant to the control group, and does not affect the eating and drinking behavior, so good for consumption because it gives a beneficial effect on health liver organ. How to Cite

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“…By showing that ascorbic acid could elevate glutathione levels through the pentose phosphate pathway, it has been previously documented that the relationship between ascorbic acid and glutathione was inverse (22). On the other hand, several studies showed that ROS sensitize the T cells (9,19) to apoptosis by decreasing the expression of Bcl-2 protein, which may result in mitochondrial dysfunction by unbinding the Bcl-2 protein from mitochondrial PBR (25). Such observations are in accordance with the fi ndings that ascorbic acid in various cell types (23) and thymocytes (20) up-regulates the Bcl-2 protein expression.…”

Section: Discussionmentioning

confidence: 99%

Protective role of vitamin C in diazepam-induced apoptosis in rat thymocytes

Pavlović¹,

Pavlović²,

Kamenov³

et al. 2012

BLL

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Diazepam, a peripheral-type benzodiazepine receptor ligand, is widely used as a therapeutic agent. On the other hand, peripheral-type benzodiazepines have been shown to induce apoptosis in different immune cell types. In this study, we examined the possible protective role of vitamin C in diazepam-induced apoptosis and evaluated the cellular content of glutathione during this process. Rat thymocytes were incubated for 24 hours with diazepam and increasing concentrations of vitamin C or with diazepam alone. The exposure to diazepam resulted in an increase in apoptotic cell death and decrease in glutathione content in rat thymocytes. Vitamin C was effective in ameliorating the effect of diazepam in rat thymocytes by decreasing the proportion of apoptotic cells and increasing the cellular content of glutathione. These results suggest that vitamin C reduced the diazepam-induced apoptosis in rat thymocytes by restoring the cellular content of glutathione, which may be useful in preventing the diazepam-induced immunosupression (Tab. 1, Fig. 1

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Effect of monosodium glutamate on oxidative stress and apoptosis in rat thymus

Cited by 57 publications

References 41 publications

The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes

The effect of vitamin C on amiodarone-induced toxicity in rat thymocytes

The Effect of Red Fruit Oil (Pandanus conoideus) to the Histophysiology of Rat (Rattus norvegicus) Liver Exposed to Cigarette Smoke

Protective role of vitamin C in diazepam-induced apoptosis in rat thymocytes

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