Effect of monosodium glutamate (MSG) on behavior, body and brain weights of exposed rats

Akataobi, Uche Stephen

doi:10.4103/ed.ed_31_19

Cited by 7 publications

(7 citation statements)

References 2 publications

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“…The present results revealed that MSG administration induced significant increase in body weight gain, total feed intake, and hence feed efficiency ratio. These results were in agreement with several previous studies (Gomathi et al, 2008;Akataobi, 2020 andHossain et al, 2020). Studies have shown that MSG administration can induce over weight through various mechanisms.…”

Section: Discussionsupporting

confidence: 94%

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

El-Hashash

2021

Alexandria Science Exchange Journal

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High intake of monosodium glutamate (MSG)containing foods was reported as a major health problem in Egypt. Thus, dietary interventions aim to prevent the deleterious effects of this additive were badly needed. This study was carried out to investigate the effect of concurrent consumption of MSG and Spirulina (S. platensis) on body weight as well as hepato-renal functions and histopathology in female rats. Twenty adult female albino rats were divided into four equal groups, including the control group, while groups 2 to 4 were administered 6 mg MSG/kg body weight daily, and kept untreated (group 2), or concurrently fed pelleted balanced diet supplemented with 0.5 and 1 % of Spirulina powder for 6 weeks (groups 3 and 4, respectively). At the end, body weight gain, feed intake and feed efficiency ratio were calculated. Liver and kidney functions were determined in sera, while oxidative stress markers were determined in liver and kidney tissue homogenates. Moreover, specimens from liver and kidney of sacrificed rats were histopathologically examined. On the other hand, phenolic profile of Spirulina powder was identified and quantified by HPLC. Findings indicated that MSG consumption resulted in overweight, liver and kidney dysfunction along with oxidative stress, which was further confirmed by histological staining. Due to the high content of phenolic compounds rather than other antioxidant agents, Spirulina powder exerted anti-obesity properties and alleviated the toxic hepato-renal effects caused by MSG consumption. So, dietary supplementation of MSG -containing food products with Spirulina powder is recommended to prevent its accompanied health abnormalities.

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Section: Discussionsupporting

confidence: 94%

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

El-Hashash

2021

Alexandria Science Exchange Journal

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“…22 Another study suggested that MSG consumption could affected the behavioral of animal included increase the anxiety and caused memory retention. 23 A study found high MSG was associated with high chromatin condensation and pycnoticnuclei of neuron cells in hippocampus 11 suggesting that the reduce of spatial memory probably due to neurotoxicity effect of MSG.…”

Section: Discussionmentioning

confidence: 98%

“…16 Another study suggested that MSGassociated neurons damages is most likely due to the effects of glutamate excitotoxicity triggered by elevated levels of Ca 2+ in the cytosol and is mediated through the process of necrosis and apoptosis mechanism of neuronal excitotoxicity. 11,17 The existence of excessive stimulation of glutamate receptors will be able to initiate a variety of potential cascades to induce cell damages and death. Moreover, MSGcould also activate glutamate receptors metabotropic causing increased release of Ca 2+ , stored in the reticulum endoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…9 MSG also possibly damagesthe central nervous system cells resulting abnormal histologicalexaminations of the cerebral cortex and hippocampus, depletion of cerebral cortex layer, damage to neurons of primary sensory area of cerebral cortex, and damage to the paraventricular nucleus of neonates whose parents fed with MSG. 2,5,10,11 Since glutamate is an essential amino acid, more thorough and vigorous studies are necessary to validate the root cause of the vivid health consequences in particular in neuropathology.The aim of this study was toassess the effects of MSG on neuron damages in the hippocampus areas in animal model.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Monosodium Glutamate (MSG) on Neuron Damages in Hippocampus in Sprague-Dawley rats

Razali,

Zulkarnain,

Asrizal

2021

Indian Journal of Forensic Medicine & Toxicology

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Introduction: Monosodium glutamate (MSG) is a flavor enhancer commonly used worldwide. Studies have shown that high dose of MSG could act as neurotoxic or excitotoxic agent for neurons in the central nervous system. The aim of this study was to determine the effect of MSG on neuron changes of hippocampusanimal model. Materials and Methods:A total of 25 white male Sprague-Dawleyrats, aged 8-10 weeks,were dividedinto 5 groups (2 control groups (i.e., none and solvent group) and3 treatment groups that received2, 4and 6 mg/ gram MSG orallyfor 30 days). Afterfour weeks on treatment, all animals were sacrificed and the entire brain tissueswere removed and immediately fixed in formalin for hematoxylin and eosin (H&E) staining.Results:The percentage of damaged neurons in three Cornuammonisareas of hippocampus was higher in animal supplemented with MSG compared to controls. At the highest MSG concentration (6 mg/gram), 52.1%, 55.2% and 66.0% of neurons from Cornuammonis 1, 2, and 3, respectively were damaged. The percentage of neuron damages in hippocampus was in dose-dependent manner. Conclusion:Our data suggested that high dose of MSG increased thehippocampus neuron damages in dosedependent effect. This suggests the neurotoxicity effect of high dose of MSG.

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“…Uche Stephen Akataobi (2020) found that in the event of exposure to MSG, it leads to the interruption of the hypothalamic signaling process of leptin, thus an animal with little movement and has the ability to eat more food [29].…”

Section: The Effect Of Msg On Food Intake Obesity and Body Immunitymentioning

confidence: 99%

The Effect of Food Additives (Monosodium Glutamate - MSG) On Human Health - A Critical Review

Al-Agili

2020

JAUC

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According to the famous saying of the medieval physician Paracelsus, "There is no substance without poison. Only the dose determines the extent of the toxic effect." Here, the effect of monosodium glutamate (MSG) on human health and the risks to the health of its frequent use in the short term was addressed and the long term was evaluated according to the studies of several researchers specializing in this regard. Monosodium glutamate (MSG) is known as one of the most popular food additives that classified as a flavor enhancer. Parts of the evidence were reviewed from the literature explaining its effect on immune system cells in addition to metabolic disorders by exposing individuals to obesity and what is known as metabolic syndrome, as well as reviewing a lot of evidence indicating the effect of MSG intake on the health of the kidney, liver and other parts of the body through Practical application to laboratory rats and clinical studies in humans.

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Effect of monosodium glutamate (MSG) on behavior, body and brain weights of exposed rats

Cited by 7 publications

References 2 publications

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

Effects of Monosodium Glutamate (MSG) on Neuron Damages in Hippocampus in Sprague-Dawley rats

The Effect of Food Additives (Monosodium Glutamate - MSG) On Human Health - A Critical Review

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