Effect of monomer blend and chlorhexidine-adding on physical, mechanical and biological properties of experimental infiltrants

Inagaki, Luciana Tiemi; Alonso, Roberta Caroline Bruschi; Araújo, Giovana Albamonte Spagnolo de; Souza-Junior, Eduardo José; Aníbal, Paula Cristina; Höfling, José Francisco; Pascon, Fernanda Miori; Puppin-Rontani, Regina Maria

doi:10.1016/j.dental.2016.09.028

Cited by 15 publications

(25 citation statements)

References 34 publications

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“…The value found for the Icon DC was close to the values found in other studies, that is, from 50-56% DC. 25,26 By comparing the results obtained using the commercial materials with the supposedly experimental analog (100% TEGDMA)-showing just 32.7% of DC under the same test conditions-it is clear that the remaining experimental groups can be compared only with the experimental control. As expected, raising the temperature led to improved DC, owing to increased molecular mobility and decreased viscosity of the system.…”

Section: Discussionmentioning

confidence: 99%

Can composition and preheating improve infiltrant characteristics and penetrability in demineralized enamel?

et al. 2020

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The composition of infiltrants can influence their physical properties, viscosity and depth of penetration (DP). Strategies are used to increase the DP, such as the addition of diluents or the use of heat. This study aimed to evaluate the effect of preheating and composition on physical properties and DP of infiltrants in demineralized enamel. The groups were assigned, and the following experimental formulations were made: 25%BisEMA +75%TEGDMA; 25%BisEMA +65%TEGDMA +10%ethanol; 25%BisEMA +65%TEGDMA +10%HEMA; 100%TEGDMA; 90%TEGDMA +10%ethanol; 90%TEGDMA +10%HEMA. The samples were photoactivated at two temperatures (25°C and 55°C). Degree of conversion (DC) was performed using an infrared spectrophotometer. Elastic modulus (E), flexural strength (FS) and contact angle (CA) tests were also performed. The DP of an infiltrant in demineralized enamel was determined by confocal laser scanning microscopy (CLSM) using an indirect labeling technique. The data were analyzed by two-way ANOVA and Tukey's test. DC increased after preheating in all the groups; however, 90%TEGDMA+10%ethanol showed the lowest DC for both temperatures, and the lowest E. Preheating did not influence E or FS. The CA increased at 55°C for most groups, but decreased for groups containing HEMA. Temperature did not seem to influence DP, and Icon showed the lowest DP values. The 100%TEGDMA composition showed more homogeneous penetration, whereas Icon showed heterogeneous and superficial penetration. The preheating technique does not improve all properties in all the material compositions. The composition of a material can influence and improve its properties.

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Section: Discussionmentioning

confidence: 99%

Can composition and preheating improve infiltrant characteristics and penetrability in demineralized enamel?

et al. 2020

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“…HNTs can be loaded with various antibacterial disinfectants, drugs and substances for delivering at specific areas 33) . Studies 24,25) have reported that when water soluble agents such as 1% CHX are added into the resin-blend (without nanotubes), droplets can be formed resulting in intrinsic microporosities, release of residual monomers and decreased mechanical properties such as degree of conversion, hardness and water sorption. Our results showed that the use of CHX (10 and 20wt%) encapsulated into the nanotubes (as a filler) increased the DC while keeping similar results for KHN when compared to the control group (except for the group CHX10%), indicating a benefical relationship between the resin-matrix and experimental filler.…”

Section: Discussionmentioning

confidence: 99%

“…10 or 20%) when compared to the control groups, without encapsulated CHX. Studies 24,25) have shown that without nanotubes, chlorhexidine release is drug-ratio dependent and proportional to the water sorption into the resin blends. In this case, the resin-blend modified by the addition of chlorhexidine presents a release burst during the first 24 h followed by a continuously low release for up to 5 weeks 25) .…”

Section: Discussionmentioning

confidence: 99%

“…A study 3) showed that by mixing chlorhexidine 1% into the resin matrix of a pitand-fissure sealant (Clinpro, 3M ESPE, St. Paul, MN, USA) antibacterial activity is achieved without affecting the mechanical properties of the sealant. A previous study 24) showed that the incorporation of chlorhexidine (0.1 and 0.2 wt%) in resin infiltrants did not affect the materials' properties (i.e. degree of conversion and microhardness) while presenting satisfactory inhibition of planktonic Streptococcus mutans.…”

Section: Effect Of a Chlorhexidine-encapsulated Nanotube Modified Pitmentioning

confidence: 91%

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Effect of a chlorhexidine-encapsulated nanotube modified pit-and-fissure sealant on oral biofilm

et al. 2021

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The purpose of this study was to characterize a chlorhexidine-encapsulated nanotube modified pit-and-fissure sealant for biofilm development prevention. HS (commercial control); HNT (HS+15wt%Halloysite ®-clay-nanotube); CHX10% (HS+15wt% HNTencapsulated with chlorhexidine 10%); and CHX20% (HS+15wt% HNT-encapsulated with CHX20%) were tested. Degree-ofconversion (DC%), Knoop hardness (KHN), and viscosity were analyzed. The ability of the sealant to wet the fissures was evaluated. Specimens were tested for zones of inhibition of microbial growth. S. mutans biofilm was tested by measuring recovered viability. Data were statistically analyzed (p<0.05). DC% was significantly higher for the HNT-CHX groups. For KHN, CHX10% presented a lower mean value than the other groups. Adding HNT resulted in higher viscosity values. The biofilm on CHX10% and CHX20% sealants presented remarkable CFU/mL reduction in comparison to the HS. The experimental material was able to reduce the biofilm development in S. mutans biofilm without compromising the sealant properties.

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“…New dental composites have been developed from the incorporation of antibacterial agents ( Beyth et al, 2014 ). These agents can be inorganic particles, modified monomers or additives incorporated into both the polymer matrix and the charge particles, such as zinc oxide nanoparticles ( Beyth et al, 2013 , 2014 ; Rüttermann et al, 2013 ; Tavassoli Hojati et al, 2013 ; Inagaki et al, 2016 ), silica nanoparticles functionalized with amphotericin B ( Lino et al, 2013 ), silver nanoparticles ( Fan et al, 2011 ), modified monomers containing quaternary ammonium ( Imazato et al, 2003 ; Makvandi et al, 2016 , 2018 ) and antibacterial agents immobilized in composite ( Namba et al, 2009 ; Mankovskaia et al, 2013 ). The concept of modified surfaces is reported in the scientific literature mainly for the purpose of developing antimicrobial and bioequivalent health materials ( Busscher et al, 2012 ; Silva et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Propolis in Oral Healthcare: Antibacterial Activity of a Composite Resin Enriched With Brazilian Red Propolis

et al. 2021

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The aim of this study was to obtain a Brazilian red propolis (BRP) enriched composite resin and to perform the characterization of its antibacterial activity, mechanical, and physical-chemical properties. Brazilian red propolis ethyl acetate extract (EABRP) was characterized by LC-ESI-Orbitrap-FTMS, UPLC-DAD, antibacterial activity, total flavonoids content, and radical scavenging capacity. BRP was incorporated to a commercial composite resin (RC) to obtain BRP enriched composite at 0.1, 0.15 and 0.25% (RP10, RP15 and RP25, respectively). The antibacterial activity RPs was evaluated against Streptococcus mutans by contact direct test and expressed by antibacterial ratio. The RPs were characterized as its cytotoxicity against 3T3 fibroblasts, flexural strength (FS), Knoop microhardness (KHN), post-cure depth (CD), degree of conversion (DC%), water sorption (Wsp), water solubility (Wsl), average roughness (Ra), and thermal analysis. Were identified 50 chemical compounds from BRP extract by LC-ESI-Orbitrap-FTMS. EABRP was bacteriostatic and bactericide at 125 and 500 μg/ml, respectively. The RP25 exhibited antibacterial ratio of 90.76% after 1 h of direct contact with S. mutans (p < 0.0001) while RC no showed significative antibacterial activity (p = 0.1865), both compared with cell control group. RPs and RC no showed cytotoxicity. RPs exhibited CD from 2.74 to 4.48 mm, DC% from 80.70 to 83.96%, Wsp from 17.15 to 21.67 μg/mm3, Wsl from 3.66 to 4.20 μg/mm3, Ra from 14.48 to 20.76 nm. RPs showed thermal resistance between 448–455°C. The results support that propolis can be used on development of modified composite resins that show antibacterial activity and that have compatible mechanical and physical-chemical properties to the indicate for composite resins.

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Effect of monomer blend and chlorhexidine-adding on physical, mechanical and biological properties of experimental infiltrants

Cited by 15 publications

References 34 publications

Can composition and preheating improve infiltrant characteristics and penetrability in demineralized enamel?

Can composition and preheating improve infiltrant characteristics and penetrability in demineralized enamel?

Effect of a chlorhexidine-encapsulated nanotube modified pit-and-fissure sealant on oral biofilm

Propolis in Oral Healthcare: Antibacterial Activity of a Composite Resin Enriched With Brazilian Red Propolis

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