2019
DOI: 10.1590/0101-60830000000186
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Effect of monoamine oxidase B A644G variant on nicotine dependence and/or schizophrenia risk

Abstract: Objectives: Schizophrenia (Sch) is a severe and chronic mental illness. Smoking prevalence is higher in patients with Sch than general population. We aimed to investigate the effects of MAOB gene A644G variant on nicotine dependence (ND) and Sch+ND risk in Turkish population and to evaluate by bioinformatic analysis. Methods: Present study included 161 individuals with ND, 223 patients with Sch+ND, and 96 non-smoker controls. MAOB A644G variant was analyzed using PCR-RFLP method. As the MAOB gene is located on… Show more

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Cited by 4 publications
(3 citation statements)
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“…In line with this finding, MAOB rs1799836 was not related to autism in children [ 62 , 63 ], severe agitation in patients with schizophrenia, CD, PTSD [ 23 , 30 ], anger-related traits and aggression in suicidal participants and controls [ 64 ], aggression determined using the Brown–Goodwin questionnaire [ 65 ], alcohol dependence [ 18 ], positive symptoms in schizophrenia [ 66 ], or negative emotionality in healthy subjects [ 67 ]. In contrast to our data, a moderate association of the G allele with higher scores on the Spontaneous Aggression subscale from the Freiburg Aggression Scale in alcohol-dependent patients [ 17 ], and the association with the development of schizophrenia in Han Chinese patients [ 68 ], but not in Turkish patients [ 69 ], was reported. MAOB rs1799836 might not be directly associated with CD or with delinquent behavior, but in a haplotype analysis with other polymorphisms, such as MAOA rs6323T [ 68 ] or MAOB rs1799836, rs10521432, rs6651806, and rs590551 [ 67 ], it might show significant association with altered behaviors.…”
Section: Discussioncontrasting
confidence: 99%
“…In line with this finding, MAOB rs1799836 was not related to autism in children [ 62 , 63 ], severe agitation in patients with schizophrenia, CD, PTSD [ 23 , 30 ], anger-related traits and aggression in suicidal participants and controls [ 64 ], aggression determined using the Brown–Goodwin questionnaire [ 65 ], alcohol dependence [ 18 ], positive symptoms in schizophrenia [ 66 ], or negative emotionality in healthy subjects [ 67 ]. In contrast to our data, a moderate association of the G allele with higher scores on the Spontaneous Aggression subscale from the Freiburg Aggression Scale in alcohol-dependent patients [ 17 ], and the association with the development of schizophrenia in Han Chinese patients [ 68 ], but not in Turkish patients [ 69 ], was reported. MAOB rs1799836 might not be directly associated with CD or with delinquent behavior, but in a haplotype analysis with other polymorphisms, such as MAOA rs6323T [ 68 ] or MAOB rs1799836, rs10521432, rs6651806, and rs590551 [ 67 ], it might show significant association with altered behaviors.…”
Section: Discussioncontrasting
confidence: 99%
“…Regarding variations in the MAOB gene, the A allele of the MAOB rs1799836 polymorphism (A> G) is associated with a lower risk of heavy smoking in men 72 . However, this association is contradicted by other studies 66,105 . Interactions between this SNP with other polymorphisms seem to interfere with the risk of smoking 70,73 .…”
Section: Polymorphisms Of the Maoa And Maob Genesmentioning
confidence: 59%
“…Catecholamine neurotransmitters, such as dopamine, are found in the brain [ 186 ]. Parkinson's disease, schizophrenia, obsessive-compulsive disorder, bipolar disorder, and hyperactivity-hyperactivity disorder are only a few of the CNS illnesses where dopamine plays a major role [ 187 , 188 ]. D1 and D2 dopamine receptors are two subclasses of G protein-coupled receptors (GPCRs), which are responsible for the action of dopamine.…”
Section: Treatment Of Psychiatric Disordersmentioning
confidence: 99%