Effect of Mometasone Furoate on Nasal Congestion Model in Rats

Abstract

Aims: The present study was performed to evaluate the effect of mometasone furoate on a nasal congestion model in Brown Norway rats. Methods: Nasal congestion in rats sensitized with toluene-2,4-diisocyanate (TDI) was measured using whole-body plethysmography which allowed animals to move freely. Results: Penh (enhanced pause), an index of nasal congestion, was significantly increased after 5% TDI challenge in sensitized rats compared with that in non-sensitized rats. The peak of the increase in Penh appeared at 1 and 5 h after TDI challenge. A single topical administration of mometasone furoate (0.05%) at 1 h before TDI challenge suppressed the increase of Penh in sensitized rats. A significant effect was observed 5–6 h after nasal administration. Almost the same results were obtained with fluticasone propionate (0.05%). Conclusion: Mometasone furoate may therefore be effective and have a rapid onset of action in nasal congestion when used clinically as with fluticasone propionate.

Perbandingan Efektivitas Spray Mometasone Furoat dan Deksamethason Intravena dalam Mengurangi Nyeri Tenggorokan setelah Operasi pada Anestesi Umum Intubasi Endotrakeal

“…Efek siginifikan terlihat setelah pemberian dalam 5-6 jam. 12 Pada penelitian ini, spray mometasone furoat, merupakan kortikosteroid potensi sedang, dengan mekanisme kerja sebagai antiinflamasi lokal, Menurunkan permeabilitas kapiler dan produksi mucus, menyebabkan vasokonstriksi pada mukosa jalan napas 13 Frieri M dan kawan-kawan (1998) dalam penelitiannya menyimpulkan bahwa efek klinis mometasone furoat nasal spray pada penderita rhinitis alergik seasonal terdiri dari dua fase, yaitu menurunkan level histamine pada sekresi nasal (respon fase awal) yang terlihat dalam 30 menit setelah pemberian dan menurunkan IL-6, IL-8, dan eosinofil selama respon fase lambat. 13 Deksamethason dapat mengurangi sintesis mediator inflamasi, prostaglandin, dan leukotrien dengan menghambat phospholipase A 2 dan juga menghambat cyclo-oxygenase selama proses inflamasi.…”