Effect of modified Zhuye Shigao Decoction (加味竹叶石膏汤) and its components on preventing radiation esophagitis of rats

Lu, Jun-zhang; Wang, Chen; Yang, Mei; Zhao, Hong; Liu, Yi; Cao, Xiutang

doi:10.1007/s11655-014-1754-1

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…48 Chinese scholars treated 31 patients with grade 3 RE with oral GM-CSF for five consecutive days, with RE reduced from grade 3 to 0-1 in 13 cases (41.94%), reduced to grade 2 in 15 cases (48.39%), and remaining at grade 3 in three cases (9.68%). The total effectiveness rate was 90.32%, 49 which is similar to the above findings. 48…”

Section: Pharmacotherapysupporting

confidence: 89%

“…For example, the oral liquid of Baimudan root can repair damaged cellular and humoral immunity by regulating CD3+, CD4+, and CD8+ T lymphocyte counts and IgG and complement C3 levels, thus reducing the severity of RE 50 . The modified Zhuye Shigao decoction can prevent and treat RE by decreasing the production and release of inflammatory factors such as tumor necrosis factor‐alpha (TNF‐α), IL‐1β, and IL‐8 49 …”

Section: Treatmentmentioning

confidence: 99%

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Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced esophagitis

Yang,

Wang,

Yuan

2023

Precision Radiation Oncology

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Radiation‐induced dermatitis is one of the most prevalent complications in patients undergoing cancer radiotherapy and poses a significant challenge in cancer therapy. The symptoms encompass erythema, dry desquamation, and moist desquamation, which are frequently observed in patients with breast cancer, head and neck cancer, anal cancer, and vulvar cancer. Early skin reactions typically manifest within 2 to 4 weeks following the commencement of radiotherapy.In severe cases, acute dermatitis can cause radiotherapy interruptions, prolong treatment time, and ultimately affect patients' outcomes and quality of life. At present, there are numerous guidelines on radiation dermatitis abroad, including the Multinational Association of Supportive Care in Cancer (MASCC), British Columbia Cancer Agency (BCCA), Oncology Nursing Society (ONS), and UK Society of Radiographers (SCoR) guidelines. In China, there was a consensus drafted by dermatology experts. However, due to the differing backgrounds of experts, recommendations between guidelines vary. This guideline was developed for the first time by the Chinese radiation oncologist. This evidence‐based guideline fully considers and adopts China's national conditions; hence, itcan be easily applied in our daily practice.

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Section: Pharmacotherapysupporting

confidence: 89%

Section: Treatmentmentioning

confidence: 99%

Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced esophagitis

Yang,

Wang,

Yuan

2023

Precision Radiation Oncology

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“…In addition, it is difficult to protect the pericarcinous tissues from radiation injury [ 27 , 28 ]. Previous reports have suggested that compounds used in Chinese herbal medicine may be able to mitigate TBI-induced damage in the brain [ 29 ], myocardium [ 30 ], esophagus [ 31 ] and BM [ 32 , 33 ] of irradiated mice or rats. It has been shown that YYF can promote hematopoietic recovery [ 13 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Yiqi and Yangyin Formula ameliorates injury to the hematopoietic system induced by total body irradiation

Zhang

Lü

et al. 2017

Journal of Radiation Research

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In this study, we examined whether the Yiqi and Yangyin Formula (YYF), used in traditional Chinese medicine, could ameliorate damage to the hematopoietic system induced by total body irradiation (TBI). Treatment with 15 g/kg of YYF increased the survival rate of Institute of Cancer Research (ICR) mice exposed to 7.5 Gy TBI. Furthermore, YYF treatment increased the white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB) and hematocrit (HCT) counts in ICR mice exposed to 2 Gy or 4 Gy TBI. Treatment with YYF also increased the number of bone marrow cells, hematopoietic progenitor cells (HPCs), hematopoietic stem cells (HSCs) and the colony-forming ability of granulocyte–macrophage cells. YYF alleviated TBI-induced suppression of the differentiation ability of HPCs and HSCs and decreased the reactive oxygen species (ROS) levels in bone marrow mononuclear cells (BMMNCs), HPCs and HSCs from mice exposed to 2 Gy or 4 Gy TBI. Overall, our data suggest that YYF can ameliorate myelosuppression by reducing the intracellular ROS levels in hematopoietic cells after TBI at doses of 2 Gy and 4 Gy.

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“…[22] Many clinical or animal experimental studies [37–40] showed that Chinese medicinal herbs could alleviate the radiotherapy-related toxicity. Aidi injection is an adjuvant chemotherapy drug commonly used in China.…”

Section: Discussionmentioning

confidence: 99%

Can Aidi injection alleviate the toxicity and improve the clinical efficacy of radiotherapy in lung cancer?

Xiao

Liang²,

Wang

et al. 2016

Medicine

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Effect of modified Zhuye Shigao Decoction (加味竹叶石膏汤) and its components on preventing radiation esophagitis of rats

Abstract: MZSD prevents the development of radiation esophagitis probably by inhibiting the generation and release of the inflammatory cytokines TNF-α, IL-1β and IL-8.

Cited by 6 publications

References 7 publications

Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced esophagitis

Chinese clinical practice guidelines for the prevention and treatment of radiation‐induced esophagitis

The Yiqi and Yangyin Formula ameliorates injury to the hematopoietic system induced by total body irradiation

Can Aidi injection alleviate the toxicity and improve the clinical efficacy of radiotherapy in lung cancer?

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