The usage of smartphone is increasing rapidly, and it is treated as a symbol of status among the young generation, especially university students. The study is conducted to determine symptoms of excessive use of smartphones on university students’ sound health. Among 350 students of Accounting and Information Systems (AIS), 289 voluntarily responded to answer the close-ended questionnaire with a five-point Likert Scale. To test and analyze the collected data, Cronbach’s Alpha, mean, standard deviation, coefficient of variation, correlation analysis, factor analysis, and regression analysis are applied with the help of SPSS v25. The eye problem, physically uncomfortable, decreased academic performance, headaches, frustration, abstaining from indoor/outdoor games, physical exercise, and woes in family bonding have a significant correlation with the health conditions of the students and a significant impact on the dependent variable indicating abstaining from gaming, headache, and frustration are liable for overall uneasy feelings. Proper authorities should formulate effective policies to engage the students in different types of indoor and outdoor games, extra-curricular activities like debating, cultural programs (such as singing, playing, and dancing), quiz competitions, science fairs, and job fairs for improving mental health as well as physical activities.