Effect of mobile‐phase modifiers on the enantioselective retention behavior of methyl mandelate with an amylose 3,5‐dimethylphenylcarbamate chiral stationary phase under reversed‐phase conditions
Abstract:In this study, methanol, ethanol, n‐propyl alcohol, isopropyl alcohol, acetone, and tert‐butanol were used as organic modifiers in reversed‐phase mode chiral liquid‐chromatography to systematically investigate the effects of mobile phase components on the enantioselective retention behavior of methyl mandelate with immobilized amylose 3,5‐dimethylphenylcarbamate‐based sorbent called Chiralpak IA. A two‐site enantioselective model was used to obtain information on the recognition mechanisms by observing the dep… Show more
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