Effect of mitochondrial‐targeted antioxidants on glycaemic control, cardiovascular health, and oxidative stress in humans: A systematic review and meta‐analysis of randomized controlled trials

Mason, Shaun; Wadley, Glenn D.; Keske, Michelle A.; Parker, Lewan

doi:10.1111/dom.14669

Cited by 16 publications

(9 citation statements)

References 42 publications

(229 reference statements)

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“…In general, low dietary intakes of antioxidant minerals and vitamins and a diet low in fruit and vegetables predict increased OS in adolescents and adults [ 66 , 67 , 68 ]. Increased OS is associated with metabolic risk factors and may contribute to the development of different comorbidities, including type 2 diabetes, cardiometabolic diseases, and atherosclerosis [ 8 , 69 , 70 , 71 ]. In addition, it has been found that similar to obese adults, obese children show a higher degree of OS than normal-weight children [ 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Intake, Nutritional Adequacy, and Food Sources of Selected Antioxidant Minerals and Vitamins; and Their Relationship with Personal and Family Factors in Spanish Children Aged 1 to <10 Years: Results from the EsNuPI Study

et al. 2022

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Minerals and vitamins involved in the antioxidant defense system are essential for healthy growth and proper development during infancy. Milk and dairy products are of particular importance for improving the supply of these nutrients to children. Indeed, the present study aimed to evaluate the nutrient intake and food sources of zinc (Zn), selenium (Se), retinol and carotenoids (sources of vitamin A), and vitamins C and E, and to analyze their relationships with personal and familiar factors in Spanish children from the EsNuPI study. One subpopulation representative of the Spanish population from 1 to <10 years old (n = 707) (reference group, REF) who reported consuming all types of milk over the last year, and another subpopulation of the same age who reported consuming fortified milk formulas (FMFs) (including follow-on formula, young child formula, growing up milk, toddler’s milk, and enriched and fortified milk) (n = 741) (fortified milk consumers, FMCs) completed two 24 h dietary recalls used to estimate their nutrient intakes and to compare them to the European Food Safety Authority (EFSA) Dietary Reference Values (DRVs). The REF reported higher median intakes than FMCs for Se (61 µg/kg vs. 51 µg/kg) and carotenoids (1079 µg/day vs. 998 µg/day). Oppositely, FMCs reported higher intakes than REF for Zn (7.9 mg/day vs. 6.9 mg/day), vitamin A (636 µg/day vs. 481 µg/day), vitamin E (8.9 mg/day vs. 4.5 mg/day), vitamin C (113 mg/day vs. 71 mg/day), and retinol (376 µg/day vs. 233 µg/day). In the REF group, more than 50% of the children met the EFSA recommendations for Zn (79.6%), Se (87.1%), vitamin A (71.3%), and vitamin C (96.7%), respectively. On the other hand, 92.2% were below the EFSA recommendations for vitamin E. In the FMC group, more than 50% of the children met the EFSA recommendations for Zn (55.2%), Se (90.8%), vitamin A (75.7%), vitamin E (66.7%), and vitamin C (100%). We found statistically significant differences between subpopulations for all cases except for Se. In both subpopulations, the main sources of all antioxidant nutrients were milk and dairy products. For carotenoids, the main sources were vegetables and fruits followed by milk and dairy products. A high percentage of children had vitamins A and E intakes below the recommendations, information of great importance to stakeholders. More studies using intakes and biomarkers are needed, however, to determine an association with diverse factors of oxidative damage.

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Section: Discussionmentioning

confidence: 99%

Dietary Intake, Nutritional Adequacy, and Food Sources of Selected Antioxidant Minerals and Vitamins; and Their Relationship with Personal and Family Factors in Spanish Children Aged 1 to <10 Years: Results from the EsNuPI Study

et al. 2022

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“…In cell culture, it reduced mitochondrial ROS production in HUVECs treated with plasma from PE patients. Both MitoQ and MitoTEMPO have been tested in humans and found to be tolerable with no adverse effect [ 162 , 163 , 164 , 165 ]. MitoQ has been reported to reduce liver inflammation in patients with chronic hepatitis C virus (HCV) infection [ 163 ].…”

Section: Potential For Mitochondrial Targeting Therapies In Preeclampsiamentioning

confidence: 99%

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Jahan

Vasam

Green

et al. 2023

IJMS

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The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero–placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed.

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“…In another study, MitoTEMPO reduced mitochondrial ROS production in HUVECs treated with plasma from PE patients. Both MitoQ and mitTEMPO has been tested in humans and found to be tolerable with no adverse effect [153][154][155][156] . MitoQ has been reported to reduce liver inflammation in patients with chronic Hepatitis C Virus (HCV) infection [154].…”

Section: Mitoq and Mitotempomentioning

confidence: 99%

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Jahan¹,

Vasam²,

Green³

et al. 2023

Preprint

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The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational-parent/fetal exchange and ultimately fetal development and growth. Not surprisingly, in cases of placental dysfunction - where aspects of placental development or function become compromised - adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero-placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed.

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Effect of mitochondrial‐targeted antioxidants on glycaemic control, cardiovascular health, and oxidative stress in humans: A systematic review and meta‐analysis of randomized controlled trials

Cited by 16 publications

References 42 publications

Dietary Intake, Nutritional Adequacy, and Food Sources of Selected Antioxidant Minerals and Vitamins; and Their Relationship with Personal and Family Factors in Spanish Children Aged 1 to <10 Years: Results from the EsNuPI Study

Dietary Intake, Nutritional Adequacy, and Food Sources of Selected Antioxidant Minerals and Vitamins; and Their Relationship with Personal and Family Factors in Spanish Children Aged 1 to <10 Years: Results from the EsNuPI Study

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Placental Mitochondrial Function and Dysfunction in Preeclampsia

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