Effect of mismatching for mHA UTA2-1 on clinical outcome after HLA-identical sibling donor allo-SCT

Bosch-Vizcaya, Anna; Rodríguez-Romanos, Rocío; Nieto, José; Cámara, Rafael de la; Brunet, Salut; Vallejo, Carlos; Osca-Gelis, Gemma; Martínez-Laperche, Carolina; Buño, Ismael; Urbano-Ispizúa, Álvaro; González, Marcos; Jiménez-Velasco, Antonio; Gallardo, David

doi:10.1038/bmt.2014.234

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Genetics and Genome‐wide Studies In Heart Transplantation1

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2018

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“…It is also becoming increasingly evident that non‐HLA variants, often termed minor histocompatibility antigen (mHA), impact rejection risk in transplantation . In females receiving a male kidney allografts, worst survival outcomes were observed versus all other gender–gender D‐R combinations .…”

Section: Genetics and Genome‐wide Studies In Heart Transplantationmentioning

confidence: 99%

Applying genomics in heart transplantation

et al. 2018

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SUMMARY While advances in patient care and immunosuppressive pharmacotherapies have increased the lifespan of heart allograft recipients, there are still significant comorbidities post-transplantation and 5-year survival rates are still significant, at approximately 70%. The last decade has seen massive strides in genomics and other omics fields, including transcriptomics, with many of these advances now starting to impact heart transplant clinical care. This review summarizes a number of the key advances in genomics which are relevant for heart transplant outcomes, and we highlight the translational potential that such knowledge may bring to patient care within the next decade.

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Section: Genetics and Genome‐wide Studies In Heart Transplantationmentioning

confidence: 99%