Effect of Mirtazapine on MNNG-Induced Gastric Adenocarcinoma in Rats

Bilici, Mehmet; Çayır, Kerim; Tekin, Salim Başol; Gündoğdu, Cemal; Albayrak, Abdulmecit; Özoğul, Bünyamin; Erdemci, Burak; Süleyman, Halis

doi:10.7314/apjcp.2012.13.10.4897

Cited by 8 publications

(3 citation statements)

References 24 publications

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“…A record linkage from Finland utilizing nationwide databases did not identify any association between antidepressant exposure and incident gastric carcinoma[ 16 ]. Moreover, experimental data reported that mirtazapine prevented adenocarcinoma induction by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) in rats to a greater extent than cisplatin[ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Antidepressants and Gastric Cancer: A Nationwide Population-Based Nested Case-Control Study

et al. 2015

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BackgroundTo our knowledge, no epidemiological study has reported on whether an association between antidepressant exposure and gastric cancer exists. Herein, we aim to investigate the possible association between antidepressant exposure and gastric cancer incidence.MethodsUsing a nested case-control design, we identified 26289 cases with gastric cancer and 127984 controls from Taiwan’s National Health Insurance Research Database (NHIRD). The data were analyzed using a conditional logistic regression model adjusting for possible confounding variables.ResultsWe found antidepressant use did not increase the risk of gastric cancer. The lack of an association between antidepressant prescription and elevated gastric cancer incidence was apparent for across selective serotonin-reuptake inhibitors (SSRIs), tricyclic agents (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), reversible inhibitors of monoamine oxidase A (RIMA), trazodone, mirtazapine and bupropion. There were slightly decreased gastric cancer risks of SSRIs use (≧28 DDD group, adjusted OR = 0.87; 95% CI = 0.78–0.96). Sensitive analysis showed SSRIs, TCAs, and SNRIs did not increase gastric cancer risks significantly even in the group with peptic ulcer history.ConclusionsAn association between antidepressant exposure and gastric cancer was not apparent in this analysis.

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Section: Introductionmentioning

confidence: 99%

Antidepressants and Gastric Cancer: A Nationwide Population-Based Nested Case-Control Study

et al. 2015

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“…Gastric cancer (GC) is the fourth most common cancer and causes almost one million deaths one year worldwide (Toyoda et al 2013). Helicobacter pylori infection, lifestyle (including high-salt diet and smoking), obesity, radiation exposure, Epstein-Barr virus infection, and environmental factors increase GC risk (Bilici et al 2012;Menheniott et al 2016). GC initiates with chronic gastritis to gastric atrophy, intestinal metaplasia, dysplasia, and finally to adenocarcinoma (Menheniott et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide transcriptional analysis of Aristolochia manshuriensis induced gastric carcinoma

Wang

Tian

et al. 2020

Pharmaceutical Biology

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Context: Aristolochia manshuriensis Kom (Aristolochiaceae) (AMK) is known for toxicity and mutagenicity. Objective: The tumorigenic role of AMK has yet to be understood. Materials and methods: AMK extracts were extracted from root crude drug. SD (Sprague Dawley) rats underwent gavage with AMK (0.92 g/kg) every other day for 10 (AMK-10) or 20 (AMK-20) weeks. Stomach samples were gathered for histopathological evaluation, microarray and mRNA analysis. Results: The gastric weight to body weight ratio (GW/BW) is 1.7 in the AMK-10 cohort, and 1.8 in AMK-20 cohort compared to control (CTL) cohort. Liver function was damaged in AMK-10 and AMK-20 rats compared to CTL rats. There were no significant changes of CRE (creatinine) in AMK-10 and AMK-20 rats. Histopathological analysis revealed that rats developed dysplasia in the forestomach in AMK-10 rats, and became gastric carcinoma in AMK-20 rats. Genes including Mapk13,

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“…The success of several recent clinical trials in terms of cancer prevention among high-risk populations suggests that chemoprevention is a rational and effective strategy (Tsao et al, 2004). Chemoprevention has received considerable attention as a potential means to control the incidence of gastric cancer (Ganapathy et al, 2008;Lu et al, 2008;Xu et al, 2011;Bilici et al, 2012).…”

Section: Preventive Effect Of Actinidia Valvatamentioning

confidence: 99%

Preventive Effect of Actinidia Valvata Dunn Extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced Gastrointestinal Cancer in Rats

Wang¹,

Líu²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (15), [6363][6364][6365][6366][6367] Introduction Gastric cancer remains a major global problem. In 2008, 989,600 new stomach cancer cases and 738,000 deaths occurred, accounting for 8% of the total cases and 10% of total deaths, respectively (Jemal et al., 2011). Notwithstanding the global declining incidence of gastric cancer, mortality is continuously rising in Asian countries (Hu et al., 2004). Surgery is considered as the gold standard for localized gastric cancer, but most cases are diagnosed at an advanced stage. The five-year survival rate of patients with advanced gastric cancer for surgical treatment is less than 40% (Rasul et al., 2012). Recent primary prevention strategies for gastric cancer focus on behavior modification, including the eradication of Helicobacter pylori, reduction of salt intake, increase in food containing protective factors (fruit,vegetables, soybean products, non-fermented soy-foods,whole-grain) and vitamin C consumption, abolition of smoking, and chemoprevention (Tsugane et al., 2004 AbstractPurpose: This study was conducted to assess the preventive effect of Actinidia valvata Dunn (AVD) extract on an animal model of gastrointestinal carcinogenesis on the basis of changes in tumor incidence, cell proliferation, and apoptosis. Materials and Methods: Seventy-five male Wistar rats were divided into five different treatment groups with 15 rats in each group. Group I was given normal feed, whereas Groups II to IV were treated with 10% sodium chloride in the first six weeks and 100ug/mL of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in drinking water for 24 weeks. Group II was then given normal feed, whereas Group III was given AVD extract (0.24g/kg/day) for 12 weeks. Group IV was given AVD extract from the first week to the 36 th week, whereas Group V was treated with AVD extract alone for 36 weeks. All rats were sacrificed at the end of the 36-week experiment and assessed for the presence of gastrointestinal tumors. The occurrence of cancer was evaluated by histology. Bax, Bcl-2, Caspase-3, and cyclinD1 were determined by immunohistochemical staining and Western blotting. Results: The incidences of gastric cancer were 0% in Group I, 73.3% in Group II, 33.3% in Group III, 26.7% in Group IV, and 0% in Group V. Bcl-2 and cyclinD1 expression was decreased in AVD extract treated groups, whereas Bax and Caspase-3 expression was increased. Comparison with group II revealed significant differences (p<0.01). Conclusions: AVD extract exhibits an obvious preventive effect on gastrointestinal carcinogenesis induced by MNNG in rats through the regulation of cell proliferation and apoptosis.

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Effect of Mirtazapine on MNNG-Induced Gastric Adenocarcinoma in Rats

Cited by 8 publications

References 24 publications

Antidepressants and Gastric Cancer: A Nationwide Population-Based Nested Case-Control Study

Antidepressants and Gastric Cancer: A Nationwide Population-Based Nested Case-Control Study

Genome-wide transcriptional analysis of Aristolochia manshuriensis induced gastric carcinoma

Preventive Effect of Actinidia Valvata Dunn Extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced Gastrointestinal Cancer in Rats

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