Effect of miR-467b on atherosclerosis of rats

Guan, Xiaomei; Li, Yongxin; Hai, Xin; Li, Jun; Zhao, Zonggang; Wang, Yuewei; Wang, Haofu

doi:10.1016/j.apjtm.2016.01.026

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…Previous studies demonstrated the involvement of miR-467b in cholesterol ester formation, atherosclerosis and hepatic steatosis (Ahn et al, 2011;Guan et al, 2016;Wang et al, 2017). The regulatory effect of miR-467b on pro-inflammatory cytokines inspired us to explore its role in OA progression.…”

Section: Discussionmentioning

confidence: 99%

MiR‐467b alleviates lipopolysaccharide‐induced inflammation through targeting STAT1 in chondrogenic ATDC5 cells

Jin¹,

Liao

Zhu³

2021

Int J Immunogenetics

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Osteoarthritis (OA) is a degenerative joint disease which affects a growing number of individuals worldwide. To date, obesity, prolonged life and lack of exercise are major environmental factors that contribute to the increasing prevalence of OA (Berenbaum et al., 2018). Typical pathological alterations of OA patients including articular cartilage degradation, synovial inflammation and subchondral bone thickening are responsible for pain and disability of OA patients (Loeser et al., 2012).Articular cartilage alteration is the most common and notable symptom of OA patients. Lubricin secreted by chondrocytes and synovial cells is critical for the normal function of joint (Greene et al., 2011). Under OA pathological conditions, quiescent chondrocytes are activated, accompanied by cell proliferation and secretion of inflammation-related cytokines and matrix-degrading enzymes, which further decide the fate of articular cartilage (Goldring & Marcu, 2009;Thomas et al., 2011). Therefore, a better understanding of inflammatory injury of chondrocytes is critical for exploring novel clinical strategies for OA treatment.

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Section: Discussionmentioning

confidence: 99%

MiR‐467b alleviates lipopolysaccharide‐induced inflammation through targeting STAT1 in chondrogenic ATDC5 cells

Jin¹,

Liao

Zhu³

2021

Int J Immunogenetics

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“…We recently reported that miR‐467a‐5p is rapidly up‐regulated by high glucose in vitro and in vivo and regulates angiogenesis by targeting Thbs1 mRNA 21‐24 . Others report this miRNA prevents vascular inflammation by targeting lipoprotein lipase in macrophages 21,22,25‐28 . Yet, the physiological function of miR‐467a‐5p and the physiological significance of its rapid up‐regulation by hyperglycaemia remained unknown.…”

Section: Introductionmentioning

confidence: 99%

“…[21][22][23][24] Others report this miRNA prevents vascular inflammation by targeting lipoprotein lipase in macrophages. 21,22,[25][26][27][28] Yet, the physiological function of miR-467a-5p and the physiological significance of its rapid up-regulation by hyperglycaemia remained unknown.…”

mentioning

confidence: 99%

miR‐467 regulates inflammation and blood insulin and glucose

Gajeton

Krukovets

Yendamuri

et al. 2021

J Cellular Molecular Medi

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Obesity is associated with inflammation and insulin resistance (IR), but the regulation of insulin sensitivity (IS) and connections between IS and inflammation remain unclear. We investigated the role of miR‐467a‐5p, a miRNA induced by hyperglycaemia, in regulating inflammation and blood glucose handling. We previously demonstrated that miR‐467a‐5p is induced by hyperglycaemia and inhibits the production of thrombospondin‐1 (TSP‐1), a protein implicated in regulating inflammation. To investigate the role of miR‐467 in blood glucose handling and tissue inflammation, WT C57BL/6 mice were fed chow or Western diet from 5 to 32 weeks of age and injected weekly with miR‐467a‐5p antagonist. Inhibiting miR‐467a‐5p resulted in 47% increase in macrophage infiltration and increased Il6 levels in adipose tissue, higher plasma insulin levels (98 ng/mL vs 63 ng/mL), and 17% decrease in glucose clearance without increase in weight or HDL/LDL. The antagonist effect was lost in mice on Western diet. Mice lacking TSP‐1 lost some but not all of the miR‐467 effects, suggesting Thbs1 (and other unknown transcripts) are targeted by miR‐467 to regulate inflammation. miR‐467a‐5p provides a physiological feedback when blood glucose is elevated to avoid inflammation and increased blood glucose and insulin levels, which may prevent IR.

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“…Thus, miR‐27 (with many target genes) can be a potential biomarker in the diagnosis and treatment of atherosclerosis and its complications. Moreover, overexpression of miR‐188 and miR‐467b can reduce lipid accumulation and inflammatory cytokine secretion by targeting TLR4 and LPL expression levels, respectively, in ApoE − / − mice and may be a potential approach for treating atherosclerosis . In addition, miR‐30c affects lipid metabolism so that its overexpression decreases lipid synthesis pathways and lipoprotein secretion .…”

Section: Preclinical Studies Of Mirnas In Atherosclerosismentioning

confidence: 99%

Diagnostic and theranostic microRNAs in the pathogenesis of atherosclerosis

Shoeibi

2019

Acta Physiologica

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MicroRNAs (miRNAs) are a group of small single strand and noncoding RNAs that regulate several physiological and molecular signalling pathways. Alterations of miRNA expression profiles may be involved with pathophysiological processes underlying the development of atherosclerosis and cardiovascular diseases, including changes in the functions of the endothelial cells and vascular smooth muscle cells, such as cell proliferation, migration and inflammation, which are involved in angiogenesis, macrophage function and foam cell formation. Thus, miRNAs can be considered to have a crucial role in the progression, modulation and regulation of every stage of atherosclerosis. Such potential biomarkers will enable us to predict therapeutic response and prognosis of cardiovascular diseases and adopt effective preclinical and clinical treatment strategies. In the present review article, the current data regarding the role of miRNAs in atherosclerosis were summarized and the potential miRNAs as prognostic, diagnostic and theranostic biomarkers in preclinical and clinical studies were further discussed. The highlights of this review are expected to present opportunities for future research of clinical therapeutic approaches in vascular diseases resulting from atherosclerosis with an emphasis on miRNAs. K E Y W O R D Satherosclerosis, diagnosis, miRNA, prognosis, therapeutic approaches 2 of 24 | SHOEIBI Because miRNAs have a relatively high stability under the physiological conditions of mammals, they can be used as prognostic and diagnostic markers for diseases, such as atherosclerosis. This review aims to describe and summarize miRNA expression studies in model animal experiments and clinical practices related to atherosclerosis. The expressed pattern of miRNAs contributing to atherosclerosis at different stages of the atherosclerotic process in comparison with healthy arteries is also discussed.

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Effect of miR-467b on atherosclerosis of rats

Abstract: miR-467b can alleviate the AS lesions of ApoE(-/-) rats, and its inhibiting effect on AS may be related to LPL expression.

Cited by 5 publications

References 10 publications

MiR‐467b alleviates lipopolysaccharide‐induced inflammation through targeting STAT1 in chondrogenic ATDC5 cells

MiR‐467b alleviates lipopolysaccharide‐induced inflammation through targeting STAT1 in chondrogenic ATDC5 cells

miR‐467 regulates inflammation and blood insulin and glucose

Diagnostic and theranostic microRNAs in the pathogenesis of atherosclerosis

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