Effect of Mineral Trioxide Aggregate Cements on Transforming Growth Factor β1 and Bone Morphogenetic Protein Production by Human Fibroblasts In Vitro

Guven, Gunseli; Çehrelį, Zafer C.; Ural, Ali Uğur; Serdar, Muhittin; Başak, Feridun

doi:10.1016/j.joen.2006.12.020

Cited by 49 publications

(49 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This result confirms the hypothesis raised by authors of previous studies 10,11 because, in the present study, the root-adhered PDL remnants were removed prior to tooth replantation.…”

supporting

confidence: 93%

“…9 On the other hand, changing MTA dressings is not necessary, which allows for restoring the tooth in the same session of dressing removal and reduces the possibility of fracture and coronal leakage. MTA also has some important properties for the repair of replanted teeth, such as biocompatibility, ability to induce cementogenesis 10,11 and antimicrobial action.…”

mentioning

confidence: 99%

“…6 Another frequent finding is the presence of newly formed cementum on the material surface. 6,10,11 The findings of studies with gingival fibroblasts regarding the ability of MTA to induce periodontal regeneration, new cementum formation and pulp repair have suggested that this material is capable of stimulating the production of transformation growth factor (TGF), which plays a key role in regulating cell response, including cell growth and differentiation.…”

mentioning

confidence: 99%

“…Moreover, MTA does not affect the mechanical properties of dentin 9,20 and presents good biocompatibility. 3,6,10,11 When extensive PDL damage or necrosis occurs, the development of ankylosis and replacement root resorption is expected. 19 In these cases, new alveolar bone is formed and deposited in the space previously occupied by the PDL fibers that were lost, and the root is progressively resorbed and replaced by bone tissue.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Delayed tooth replantation: MTA as root canal filling

et al. 2014

View full text Add to dashboard Cite

MTA has been investigated as a root-end filling material. Its mechanism of action has some similarities to that of Ca(OH) 2 . The purpose of this study was to evaluate the repair process taking place in the delayed replantation of monkey teeth using calcium hydroxide and MTA as root canal filling materials. Five monkeys had their lateral incisors extracted and bench-dried for 60 minutes. After root canal preparation, the teeth were assigned to two groups according to root canal filling material: I, calcium hydroxide; and II, MTA. The same treatment sequence was followed for both groups: coronal seal, periodontal ligament removal, immersion of the tooth in 2% acidulated-phosphate sodium fluoride, irrigation of the socket with saline and replantation. Both groups exhibited replacement resorption, areas of ankylosis and absence of inflammatory root resorption. Statistically similar results (p > 0.05) were observed for both groups regarding replacement root resorption, but the groups differed significantly (p < 0.05) regarding the occurrence of ankylosis. MTA may be a viable clinical option for filling teeth submitted to delayed replantation, and is an acceptable option for treating replanted permanent teeth in order to prevent tooth resorption, particularly when dressing changes are not possible.

show abstract

“…This result confirms the hypothesis raised by authors of previous studies 10,11 because, in the present study, the root-adhered PDL remnants were removed prior to tooth replantation.…”

supporting

confidence: 93%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Delayed tooth replantation: MTA as root canal filling

et al. 2014

View full text Add to dashboard Cite

show abstract

“…There is evidence that MTA promotes a favorable response in osseous environment, with direct bone apposition 30 . It was demonstrated that MTA induces bone morphogenetic protein 2 expression and calcification in human periodontal ligament cells 20 and stimulating human gingival fibroblasts to produce BMP-2 14 , is able to promote a favorable formation of mineralized tissue in rat alveolar sockets 15 , being characterized by mild inflammatory response and complete bone healing 16 . MTA surfaces also support osteoblast cell attachment, matrix synthesis and RunX2 expression which are essential for osteogenesis 24 .…”

Section: Introductionmentioning

confidence: 99%

Histological and immunohistochemical evaluation of biphasic calcium phosphate and a mineral trioxide aggregate for bone healing in rat calvaria

Silva

Kim

Luczyszyn

et al. 2015

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Eighty Wistar rats were divided into 4 groups and examined over a period of 2 or 8 weeks. First, a surgical defect was created in the calvaria using a 6 mm diameter trephine drill. The cavity was then treated with BCP (biphasic calcium phosphate), MTA, or the combination of the two. In the control, the cavity was allowed to clot. After 2 or 8 weeks, animals were sacrificed and the bones were subjected to a histological evaluation and immunohistochemical staining to evaluate areas of new osteoid tissue and new bone tissue as well as the percentage of labeled cells that utilize anti-BMPR1B antibodies. Twoway ANOVA showed statistical significant diference in all dependent variable (area of new osteoid tissue; area of new bone and % of immunostainning) within group p=0.00000, time p=0.00000 and with the interaction of both p=0.0000. MTA group at 8 weeks showed the highest amount of osteoid tissue (6.25 ± 0.30 mm 2 ). The same group also exhibited the highest amount of bone tissue formation (3.98 ± 0.14 mm 2 ). In contrast, both 2-week MTA samples (40.73 ± 2.50%) and 2-week BCP+MTA samples (40.30 ± 1.81%) exhibited the highest percentage of stained cells. Best results in terms of the area of osteoid and bone tissue formation and the percentage of BMPR1B markings were observed for the MTA group, confirming that the combination of BCP and MTA does not result in a significant improvement.

show abstract