Effect of Mineral Particles Containing Iron on Primary Cultures of Rabbit Tracheal Epithelial Cells: Possible Implication of Oxidative Stress

Guilianelli, Catherine; Baeza-Squiban, Armelle; Boisvieux‐Ulrich, Emmanuelle; Houcine, Odile; Zalma, Roger; Guennou, Christiane; Pézerat, H.; Marano, Francelyne

doi:10.2307/3431902

Cited by 9 publications

(8 citation statements)

References 2 publications

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“…121 Inflammation may be related to the ability of particles to induce formation of free oxygen radicals, which in turn may depend on the particle concentration of surface-complexed iron (Fe 3+ ). [122][123][124] The toxicological studies are making a start at identifying specific particle components or features and elucidating mechanisms that may be responsible for the health effects attributed to particle exposure in the observational studies.…”

Section: Toxicological Animal Studies Preliminary Reports Of Recentmentioning

confidence: 99%

Ambient Particles and Health: Lines that Divide

Vedal

1997

Journal of the Air & Waste Management Association

392

229

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Section: Toxicological Animal Studies Preliminary Reports Of Recentmentioning

confidence: 99%

Ambient Particles and Health: Lines that Divide

Vedal

1997

Journal of the Air & Waste Management Association

392

229

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“…Numerous in-vivo and in-vitro studies have indicated that iron (Fe) may be involved in lung injury , (Pritchard 1996), (Gavett et al, 1997), (Smith et al, 2000), (Guilianelli et al, 1993), and (Smith and Aust, 1997). However, an in-vivo study conducted by (Peters et al, 2000), in which animals exposed to the exhaust of an engine which combusted doped fuel with ferrocene, demonstrated no significant changes in health effects.…”

Section: Characteristics Of Re-suspended Ash Particlesmentioning

confidence: 95%

NOx, FINE PARTICLE AND TOXIC METAL EMISSIONS FROM THE COMBUSTION OF SEWAGE SLUDGE/COAL MIXTURES: A SYSTEMATIC ASSESSMENT

Wendt¹

2002

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This research project focuses on pollutants from the combustion of mixtures of dried municipal sewage sludge (MSS) and coal. The objective is to determine the relationship between 1) fraction sludge in the sludge/coal mixture, and 2) combustion conditions on a) NOx concentrations in the exhaust, b) the size segregated fine and ultra-fine particle composition in the exhaust, and c) the partitioning of toxic metals between vapor and condenses phases, within the process. The proposed study will be conducted in concert with an existing ongoing research on toxic metal partitioning mechanisms for very well characterized pulverized coals alone. Both high NOx and low NOx combustion conditions will be investigated (unstaged and staged combustion). Tradeoffs between CO 2 control, NO x control, and inorganic fine particle and toxic metal emissions will be determined.Previous research has yielded data on trace metal partitioning for MSS by itself, with natural gas assist, for coal plus MSS combustion together, and for coal alone. We have re-evaluated the inhalation health effects of ash aerosol from combustion of MSS both by itself and also together with coal. We have concluded that ash from the co-combustion of MSS and coal is very much worse from an inhalation health point of view, than ash from either MSS by itself or coal by itself. The reason is that ZnO is not the "bad actor" as had been suspected before, but the culprit is, rather, sulfated Zn. The MSS supplies the Zn and the coal supplies the sulfur, and so it is the combination of coal and MSS that makes that process environmentally bad. If MSS is to be burned, it should be burned without coal, in the absence of sulfur.4

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“…Experiments in lympho‐myelold cells indicate that ferrienzymes are involved in cell proliferation and maturation [20, 21]. When tracheal cell cultures were used to study oxidative stress and cytotoxicity, particles containing Fe 2+ proved to be more cytotoxic than Fe 3+ in inducing squamous metaplasia [22]. The metaplasia was less when the iron particles were pretreated with the iron‐chelator desferrioxamine.…”

Section: Iron In the Physiology Of The Skinmentioning

confidence: 99%

Iron: a cosmetic constituent but an essential nutrient for healthy skin

Lansdown

2001

Intern J of Cosmetic Sci

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Iron compounds have an established role as colorants in many cosmetic products applied to the skin, hair and nails. Evidence is reviewed showing that in addition to its importance as an essential nutrient necessary for oxygen metabolism and mitrochondrial function, iron exhibits a fundamental importance as a trace metal in the normal growth and functional maturation of the skin and in the health of hair and nails. The implications of iron from cosmetic sources in the nutrition of human skin is discussed.

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Effect of Mineral Particles Containing Iron on Primary Cultures of Rabbit Tracheal Epithelial Cells: Possible Implication of Oxidative Stress

Abstract: We thank F. Meury, Laboratoire d'Anatomie Comparee, for valuable technical assistance with the scanning electron microscope and M. J. Falxa for technical assistance. This work was supported by grants from DRED, Action specifique toxicologie de l'environnement, and MRE 91C0543 and 91739.

Cited by 9 publications

References 2 publications

Ambient Particles and Health: Lines that Divide

Ambient Particles and Health: Lines that Divide

NOx, FINE PARTICLE AND TOXIC METAL EMISSIONS FROM THE COMBUSTION OF SEWAGE SLUDGE/COAL MIXTURES: A SYSTEMATIC ASSESSMENT

Iron: a cosmetic constituent but an essential nutrient for healthy skin

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