Effect of Mineral Nutrition and PGRs on Biosynthesis and Distribution of Secondary Plant Metabolites under Abiotic Stress

Jan, Rahmatullah; Lubna,; Asaf, Sajjad; Khan, Muhammad Aaqil; Kim, Kyung Min

doi:10.1007/978-981-19-5611-9_11

Cited by 26 publications

(30 citation statements)

References 187 publications

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“…Compound 4 has been previously isolated from Rhamnus nakaharai Hayata (Rhamnaceae) and reported to inhibit PDE5 enzymes isolated from the lungs and hearts of male guinea pigs with an IC 50 value of 86.9 µM [43], 3 and 5 have been previously isolated from Anaxagorea luzonensis and reported to inhibit PDE5 enzymes isolated from the mice lungs [14], while 1, 2, and 6 has not previously been reported for their effects on PDE5. Moreover, quercetin, kaempferol, and their derivatives have shown other biological activities such as antibacterial, antifungal, and anti-oxidative properties including reducing LDL oxidation, platelet aggregation, and cardiovascular complications [44].…”

Section: Discussionmentioning

confidence: 99%

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families

et al. 2023

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The objectives of this study were (1) to investigate the effect of extracts from some plants in the families Nelumbonaceae and Nymphaeaceae on phosphodiesterase 5 (PDE5) and arginase, which have been used in erectile dysfunction treatment, and (2) to isolate and identify the compounds responsible for such activities. The characterization and quantitative analysis of flavonoid constituents in the active extracts were performed by HPLC. Thirty-seven ethanolic extracts from different parts of plants in the genus Nymphaea and Victoria of Nymphaeaceae and genus Nelumbo of Nelumbonaceae were screened for PDE5 and arginase inhibitory activities. The ethanolic extracts of the receptacles and pollens of Nelumbo nucifera Gaertn., petals of Nymphaea cyanea Roxb. ex G.Don, Nymphaea stellata Willd., and Victoria amazonica (Poepp.) Sowerby and the petals and receptacles of Nymphaea pubescens Willd. showed IC50 values on PDE5 of less than 25 μg/mL while none of the extracts showed effects on arginase. The most active extract, N. pubescens petal extract, was fractionated to isolate and identify the PDE5 inhibitors. The results showed that six flavonoid constituents including quercetin 3’-O-β-xylopyranoside (1), quercetin 3-methyl ether 3’-O-β-xylopyranoside (2), quercetin (3), 3-O-methylquercetin (4), kaempferol (5) and 3-O-methylkaempferol (6) inhibited PDE5 with IC50 values at the micromolar level.

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Section: Discussionmentioning

confidence: 99%

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families

et al. 2023

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“…Moreover, most of the luteolin compounds (four out of seven) were up-accumulated in YF in comparison to PF (Table 1; Table S4E). Additionally, other beneficial flavonoid compounds such as quercetin, kaempferol, and others found in Table S4A-F had varied accumulation among the four varieties [38].…”

Section: Overview Of Metabolome Profiling Among the Four Varieties Of...mentioning

confidence: 95%

Comparative Metabolome Profiles and Antioxidant Potential of Four Coffea arabica L. Varieties Differing in Fruit Color

et al. 2023

Diversity

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Coffee (Coffea arabica L.) is one of the most consumed non-alcoholic beverages. To expand the coffee market and attract consumers to a diversity of coffee types, data on the nutritional potential of different coffee varieties are needed. The present study assessed the phytochemical constituents, i.e., total flavonoid content (TFC), total anthocyanin content (TAC), and total phenolic content (TPC), and the antioxidant activities of extracts from Bourbon coffee berries differing in color. Furthermore, the metabolome profiles of the four Bourbon berries, i.e., purple (PF), red (RF), orange (ORF), and yellow (YF), were explored. The results indicated that the TFC and TPC were significantly higher in RF (7.12 ± 0.96 and 9.01 ± 1.36 mg/g), followed by YF (6.54 ± 0.38 and 7.80 ± 0.10 mg/g), ORF (6.31 ± 0.15 and 7.20 ± 0.40 mg/g), and PF (4.66 ± 0.53 and 6.60 ± 1.10 mg/g). A UPLC-MS/MS analysis resulted in the identification of 579 metabolites belonging to 11 different compound classes. Of these, 317 metabolites were differentially accumulated in the four varieties. These differentially accumulated metabolites were majorly classified as flavonoids, organic acids, phenolics, and amino acids and derivatives. Based on the metabolome profiles, we discuss the major compounds in each Bourbon coffee variety and highlight their nutritional and health potentials. These findings will serve as a foundation for the promotion of each variety and provide useful information for coffee improvement programs.

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“…However, common phenolics present in different sources, for example, quercetin, which is contained in different matrices such as apple, chocolate, or cherry [15], have been shown to have both antioxidant and tyrosinase inhibitory actions [16]. Another example is kaempferol, another flavonoid, which is also present in a wide variety of plants and has a high antioxidant capacity [17]. When compared to other groups-for example, verbascoside, which belongs to the phenylpropanoids and is present in different matrices such as Lippia citriodora and Olea europaea-they have also been shown to have a high antioxidant capacity [18].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets

Villegas-Aguilar,

Sánchez-Marzo,

Fernández-Ochoa

et al. 2024

Antioxidants

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Plant extracts rich in phenolic compounds have been reported to exert different bioactive properties. Despite the fact that there are plant extracts with completely different phenolic compositions, many of them have been reported to have similar beneficial properties. Thus, the structure–bioactivity relationship mechanisms are not yet known in detail for specific classes of phenolic compounds. In this context, this work aims to demonstrate the relationship of extracts with different phenolic compositions versus different bioactive targets. For this purpose, five plant matrices (Theobroma cacao, Hibiscus sabdariffa, Silybum marianum, Lippia citriodora, and Olea europaea) were selected to cover different phenolic compositions, which were confirmed by the phytochemical characterization analysis performed by HPLC-ESI-qTOF-MS. The bioactive targets evaluated were the antioxidant potential, the free radical scavenging potential, and the inhibitory capacity of different enzymes involved in inflammatory processes, skin aging, and neuroprotection. The results showed that despite the different phenolic compositions of the five matrices, they all showed a bioactive positive effect in most of the evaluated assays. In particular, matrices with very different phenolic contents, such as T. cacao and S. marianum, exerted a similar inhibitory power in enzymes involved in inflammatory processes and skin aging. It should also be noted that H. sabdariffa and T. cacao extracts had a low phenolic content but nevertheless stood out for their bioactive antioxidant and anti-radical capacity. Hence, this research highlights the shared bioactive properties among phenolic compounds found in diverse matrices. The abundance of different phenolic compound families highlights their elevated bioactivity against diverse biological targets.

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Effect of Mineral Nutrition and PGRs on Biosynthesis and Distribution of Secondary Plant Metabolites under Abiotic Stress

Cited by 26 publications

References 187 publications

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families

Comparative Metabolome Profiles and Antioxidant Potential of Four Coffea arabica L. Varieties Differing in Fruit Color

Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets

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