Effect of mild mental stress on solid phase gastric emptying in healthy subjects

Roland, J; Dobbeleir, André; Vandevivere, Johan; Ham, Hamphrey

doi:10.1097/00006231-199004000-00011

Cited by 19 publications

(17 citation statements)

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“…However, when measuring GE using a NG tube in a healthy cohort, it is important that the subjects are accustomed to the positioning of a NG tube prior to the study. The rate of GE is exquisitely sensitive to stress or discomfort,33 34 which could result in false slow GE measurements in the control group. Accordingly, all healthy subjects in this study had undergone previous NG tube placement and appeared to be unaffected by this process.…”

Section: Discussionmentioning

confidence: 99%

Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement

Chapman

Besanko

Burgstad

et al. 2011

Gut

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Section: Discussionmentioning

confidence: 99%

Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement

Chapman

Besanko

Burgstad

et al. 2011

Gut

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“…This difference may be due, at least in part, to the added stress associated with the additional IP injections received by the subjects in Experiment 3. It has been demonstrated that stress has an inhibitory effect on gastric emptying (Mistiaen et al, 2002;Tsukada et al, 2003) similar to that of nicotine, but possibly through a different mechanism involving the sympathetic nervous system and/or corticotropin releasing factor (CRF) (Coskun et al, 1997;Lee and Sarna, 1997;Roland et al, 1990). Summarizing these findings, it suggests that the pharmacokinetic interaction between alcohol and nicotine is complex and as such may possibly be influenced by several unforeseen factors, such as stress.…”

Section: Discussionmentioning

confidence: 99%

Nicotine Decreases Blood Alcohol Concentrations in Adult Rats: A Phenomenon Potentially Related to Gastric Function

Parnell

West

Chen

2006

Alcoholism Clin & Exp Res

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These results suggest that the nicotine-induced decrease in BAC may be related to gastric function. One possible explanation was related to nicotine's action in delaying gastric emptying. The longer the alcohol was retained in the stomach, the more likely that the alcohol would be metabolized by gastric alcohol dehydrogenase before its absorption into the bloodstream by the small intestine (the major site of alcohol absorption).

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“…10 The size of this test meal was identical to the one used in our study; however, an overestimation of the emptying rate is suggested by the ®nding of an apparent mean emptying of 19 and 29 kJ per min from the stomach (lean and obese subjects, respectively), which is high compared to the solid emptying rates found in our study and described by others. 9,11,15,18,35,42,43 Overestimation of the emptying rate might be due to the fact that the test-meal consisted of a main course of 99 m Tc-labelled hamburger served with potatoes plus a non-labelled desert of cre Áme caramel. This procedure could theoretically lead to an estimation of the emptying rate for the ®rst part of the meal rather than an estimation of the overall emptying rate, 10 so what is described as an acceleration of the overall gastric emptying in obese subjects might actually represent an enhanced emptying of the part of the meal that is ingested ®rst.…”

Section: Discussionmentioning

confidence: 99%

Effect of obesity and major weight reduction on gastric emptying

et al. 2000

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BACKGROUND: An enhanced gastric emptying rate might reduce the satiating effect of food and thereby promote obesity. Gastric emptying rate has previously been compared between obese and lean subjects with con¯icting outcome. OBJECTIVE: Comparison of gastric emptying rate in lean and obese subjects before and after a major weight reduction. DESIGN: The study was designed as a case ± control study comparing obese and lean subjects and a subsequent comparison of obese subjects before and after a dietary induced major weight reduction. METHOD: Gastric emptying rate following a solid test meal was estimated scintigraphically for 3 h using the left anterior oblique projection. SUBJECTS: Nineteen non-diabetic obese (mean BMI 38.7 kgam 2 ) and 12 lean (mean BMI 23.1 kgam 2 ) males matched for age and height. All obese subjects were re-examined after a mean weight loss of 18.8 kg (95% CI, 14.4 ± 23.2) achieved by 16 weeks of dietary intervention followed by 8 weeks of weight stability. RESULTS: When comparing obese and lean subjects no differences were seen in overall 3 h emptying rate (30.3% per hour vs 30.5% per hour). However, a trend towards a higher percentage gastric emptying during the initial 30 min was seen in the obese when compared to lean subjects (24.0% vs 17.8% of the test meal; P 0.08). Weight loss was associated with a reduction in percentage gastric emptying during the initial 30 min (from 24.0% to 18.3% of the testmeal; P`0.02), whereas the overall 3 h emptying rate was unaffected (30.3% vs 30.9% per hour). Neither initial or overall emptying rate differed between reduced-obese and lean subjects. CONCLUSION: Overall 3 h gastric emptying rate was similar in obese and normal weight males, and unaffected by a major weight loss. However, percentage gastric emptying during the initial 30 min for a solid meal appeared to be increased in obese males and was normalized after a major weight reduction.

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Effect of mild mental stress on solid phase gastric emptying in healthy subjects

Cited by 19 publications

References 0 publications

Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement

Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement

Nicotine Decreases Blood Alcohol Concentrations in Adult Rats: A Phenomenon Potentially Related to Gastric Function

Effect of obesity and major weight reduction on gastric emptying

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