Effect of mild cognitive impairment on the patterns of neural activity in early Parkinson's disease

Nagano‐Saito, Atsuko; Habak, Claudine; Mejía-Constaín, Beatriz; Degroot, Clotilde; Monetta, Laura; Jubault, Thomas; Bedetti, Christophe; Lafontaine, Anne‐Louise; Chouinard, Sylvain; Soland, Valérie; Ptito, Alain; Strafella, Antonio P.; Monchi, Oury

doi:10.1016/j.neurobiolaging.2013.06.025

Cited by 80 publications

(85 citation statements)

References 33 publications

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“…The frontal cortex includes part of the frontostriatal loops (Alexander et al 1986), which have important implications for motor and non-motor symptoms of PD. Prefrontostriatal dysfunction is thought to underlie the basis for the most prominent executive impairment in PD (Nagano-Saito et al 2013;Owen 2004;Pagonabarraga and Kulisevsky 2012;Zgaljardic et al 2006). Abnormality in the SFG in particular can be an early indicator for further decline of cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

et al. 2014

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The current study investigates both gray and white matter changes in non-demented Parkinson's disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre-and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.

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Section: Discussionmentioning

confidence: 99%

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

et al. 2014

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“…One persistent finding is setshifting impairment in Parkinson's disease patients [1,39]. Cognitive flexibility appears to rely on the dorsal striatum [40 && ] and medication response correlates with improved task switching in Parkinson's disease, further supporting the dorsal striatum's role in cognitive flexibility [41].…”

Section: Cognitive Flexibility In Parkinson's Diseasementioning

confidence: 99%

Apathy and noradrenaline

Loued-Khenissi

Preuschoff

2015

Current Opinion in Neurology

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The search for PD-MCI biomarkers has employed an array of neuroimaging techniques, but still yields divergent findings. This may be due in part to MCI's broad definition, encompassing heterogeneous cognitive domains, only some of which are affected in Parkinson's disease. Most domains falling under the MCI umbrella include fronto-dependent executive functions, whereas others, notably learning, rely on the basal ganglia. Given the deterioration of the nigrostriatal dopaminergic system in Parkinson's disease, it has been the prime target of PD-MCI investigation. By testing well defined cognitive deficits in Parkinson's disease, distinct functions can be attributed to specific neural systems, overcoming conflicting results on PD-MCI. Apart from dopamine, other systems such as the neurovascular or noradrenergic systems are affected in Parkinson's disease. These factors may be at the basis of specific facets of PD-MCI for which dopaminergic involvement has not been conclusive. Finally, the impact of both dopaminergic and noradrenergic deficiency on motivational states in Parkinson's disease is examined in light of a plausible link between apathy and cognitive deficits.

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“…The threshold for displaying was set to p <0.05, alphasim corrected, cluster size > 228. More details of these color regions are described in Table 2 patients with PD-MCI compared with those with no cognitive impairment [12,[31][32][33][34]. Especially, in a recent fMRI study, Nagano-Saito et al even proposed directly that the presence of MCI in PD affects brain activity in the prefrontal cortex and some other areas [12].…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, rare rs-fMRI study focused on the effect of cognitive function decline on the patterns of neural activity in early PD patients. According to a recent study, PD-MCI patients displayed brain activity decreases in the cognitive corticostriatal loop, which included prefrontal cortex and caudate nucleus while planning a set shift task [12], and prefrontal hypometabolism was also found in metabolic studies on PD-MCI [21,22]. Taken together, these neuroimaging studies indicate that there exists aberrant neural activity in PD-MCI patients, and ReHo changes are associated with different characteristics of the disease.…”

Section: Introductionmentioning

confidence: 95%

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Altered regional homogeneity of prefrontal cortex in Parkinson’s disease with mild cognitive impairment

Kang

Chen

et al. 2016

Chin Neurosurg Jl

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Background: Mild cognitive impairment (MCI) is a common non-motor symptom of early Parkinson's disease (PD), but the neural mechanisms underlying it remain poorly understood. The aim of the present study was to investigate the characteristics of cognition-related brain activities in the PD patients with MCI. Methods: The brain fMRIs and cognition tests were acquired in 39 PD patients and 22 healthy controls (HC) from September 2013 to January 2015. The patients were divided into two groups: PD-MCI (n = 18) and PD with normal cognition (PDNC, n = 19). we used resting state fMRI and a regional homogeneity (ReHo) method to explore patterns of intrinsic brain activity in patients with PD-MCI as compared with PDNC subjects and HC. Results: Compared with the PDNC group, the PD-MCI group exhibited significantly increased ReHo in parts of the prefrontal cortex regions (e.g. right superior frontal gyrus, right middle frontal gyrus and orbitofrontal cortex). Compared to the HC group, a decrease of ReHo value in left thalamus was found in PD-MCI. However, this reduction was not found in the left thalamus of PDNC group, but in the above prefrontal regions (p < 0.05, with Bonferroni correction).Conclusions: These results demonstrate that the ReHo of prefrontal cortex in resting state is changed in PD patients with MCI. The presence of MCI in PD may be attributed to abnormal regional activity in prefrontal cortex regions.

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Effect of mild cognitive impairment on the patterns of neural activity in early Parkinson's disease

Cited by 80 publications

References 33 publications

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Apathy and noradrenaline

Altered regional homogeneity of prefrontal cortex in Parkinson’s disease with mild cognitive impairment

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