Effect of midbrain raphe nucleus stimulation on somatosensory evoked potential in cat

Iwayama, Kaoru; Mori, Kazuo; Fukushima, Masaaki; Yamashiro, Katsumi

doi:10.1080/01616412.1989.11739871

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Pharmacological enhancement of 5-HT function inhibits primary afferent neurotransmission in vitro [7], [8], dampens sensory and nociceptively-evoked firing in vivo [9]-[11], [12] and decreases acoustic startle responses and their pre-pulse inhibition [6], [13]. Similarly, electrical microstimulation of the dorsal raphe nucleus (DRN), one of the largest sources of ascending 5-HT projections [14], reduces forebrain sensory and nociceptively-evoked activity [9], [11], [12], [15]–[17] and elevates vocalization thresholds to noxious stimuli [18].…”

Section: Introductionmentioning

confidence: 99%

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice

et al. 2014

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The inhibition of sensory responsivity is considered a core serotonin function, yet this hypothesis lacks direct support due to methodological obstacles. We adapted an optogenetic approach to induce acute, robust and specific firing of dorsal raphe serotonergic neurons. In vitro, the responsiveness of individual dorsal raphe serotonergic neurons to trains of light pulses varied with frequency and intensity as well as between cells, and the photostimulation protocol was therefore adjusted to maximize their overall output rate. In vivo, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. In behaving mice, the photostimulation of dorsal raphe serotonergic neurons produced a rapid and reversible decrease in the animals' responses to plantar stimulation, providing a new level of evidence that serotonin gates sensory-driven responses.

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Section: Introductionmentioning

confidence: 99%

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice

et al. 2014

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“…In mammals, the neuromodulator serotonin can induce plasticity in the central representation of many different sensory modalities, including nociception, vision, and somatosensation (see, e.g., Rogawski and Aghajanian, 1980;Iwayama et al, 1989;Bassant et al, 1990;Waterhouse et al, 1990;Huang et al, 1993;Storer and Goadsby, 1997;Edagawa et al, 1999). Several lines of evidence suggest that serotonin modulates the central processing of audition, too.…”

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confidence: 98%

Serotonergic innervation of the auditory brainstem of the Mexican free‐tailed bat, Tadarida brasiliensis

Hurley

Thompson

2001

J of Comparative Neurology

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Anatomical and electrophysiological evidence suggests that serotonin alters the processing of sound in the auditory brainstem of many mammalian species. The Mexican free-tailed bat is a hearing specialist, like other microchiropteran bats. At the same time, many aspects of its auditory brainstem are similar to those in other mammals. This dichotomy raises an interesting question regarding the serotonergic innervation of the bat auditory brainstem: Is the serotonergic input to the auditory brainstem similar in bats and other mammals, or are there specializations in the serotonergic innervation of bats that may be related to their exceptional hearing capabilities? To address this question, we immunocytochemically labeled serotonergic fibers in the brainstem of the Mexican free-tailed bat, Tadarida brasiliensis. We found many similarities in the pattern of serotonergic innervation of the auditory brainstem in Tadarida compared with other mammals, but we also found two striking differences. Similarities to staining patterns in other mammals included a higher density of serotonergic fibers in the dorsal cochlear nucleus and in granule cell regions than in the ventral cochlear nucleus, a high density of fibers in some periolivary nuclei of the superior olive, and a higher density of fibers in peripheral regions of the inferior colliculus compared with its core. The two novel features of serotonergic innervation in Tadarida were a high density of fibers in the fusiform layer of the dorsal cochlear nucleus relative to surrounding layers and a relatively high density of serotonergic fibers in the low-frequency regions of the lateral and medial superior olive.

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“…Neuromodulators can cause the functional reconfiguration of neural circuits in both invertebrates and vertebrates (for examples, see reviews in Harris‐Warrick et al, 1992; Sillar et al, 1998). In mammals, the neuromodulator serotonin can induce plasticity in the central representation of many different sensory modalities, including nociception, vision, and somatosensation (see, e.g., Rogawski and Aghajanian, 1980; Iwayama et al, 1989; Bassant et al, 1990; Waterhouse et al, 1990; Huang et al, 1993; Storer and Goadsby, 1997; Edagawa et al, 1999). Several lines of evidence suggest that serotonin modulates the central processing of audition, too.…”

mentioning

confidence: 99%

A small dose of the immunosuppressive agent FK506 (tacrolimus) protects peripheral nerve from ischemic fiber degeneration

et al. 2001

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The immunosuppressant agent FK506 (tacrolimus) has proven to be neuroprotective against brain ischemia, but there are no data on potential neuroprotective effects of FK506 in peripheral nerve ischemia. We examined the potential effects of two doses of FK506 in protecting peripheral nerve from ischemic fiber degeneration. Ischemia in the left sciatic nerve of the rat was produced by injecting 2 x 10(6) microspheres (14 microm) into the left femoral, hypogastric, and superior gluteal arteries in proportions of 47%, 37%, and 17%, respectively. After embolization, FK506 was injected into the left femoral, hypogastric, and superior gluteal arteries in doses of 9.4, 7.4, and 3.4 microg, respectively, for the high-dose group and 4.7, 3.7, and 1.7 microg, respectively, for the low-dose group. The control rats were injected with saline. FK506 treatment resulted in dramatic behavioral improvement in nerve function, in the number of functioning nerve fibers, and in the salvage of a majority of nerve fibers from ischemic fiber degeneration in a dose-dependent fashion. These results suggest that a small dose of FK506 protects peripheral nerve from ischemic fiber degeneration and that it may have potential in the treatment of ischemic neuropathy.

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Effect of midbrain raphe nucleus stimulation on somatosensory evoked potential in cat

Cited by 4 publications

References 16 publications

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice

Optogenetic Recruitment of Dorsal Raphe Serotonergic Neurons Acutely Decreases Mechanosensory Responsivity in Behaving Mice

Serotonergic innervation of the auditory brainstem of the Mexican free‐tailed bat, Tadarida brasiliensis

A small dose of the immunosuppressive agent FK506 (tacrolimus) protects peripheral nerve from ischemic fiber degeneration

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