Effect of Midazolam on Sedation and Hemorheology in Elderly Patients with Acute Cerebral Infarction

Abstract

To explore the effect of midazolam in the treatment of senile acute cerebral infarction is the main objective. the patients were divided into observation group (n=55) and control group (n=55) by envelope method, the control group was given routine treatment, the observation group was given midazolam on the basis of the control group, the time required for sedation, mean arterial pressure, heart rate and so on were observed. There was no significant difference in sedation time between the observation group and the control group (p>0.05). The awakening time of the observation group was (8.10±1.54) min, which was significantly shorter than that of the control group (p<0.05). The mean arterial pressure and heart rate of the observation group before anesthesia induction (T1) and 30 min after anesthesia (T2) were ( 92.02±3.05) mmHg and (91.14±2.93) mmHg, (87.70±4.82) times/min and (83.02±5.01) times/min, respectively, which were significantly lower than those of the control group (p<0.05). The blood oxygen difference [D (a-jv) O 2 ] and cerebral oxygen uptake rate (ERO 2 ) at T1 and T2 in the observation group were (4.56±0.67) and (3.02±0.82), (20.20±6.73) % and (16.80±4.11) %, respectively, which were significantly lower than those in the control group (p<0.05). The scores of mini-mental state examination at 1 d and 3 d after operation in the observation group were (25.11±2.10) and (26.04±1.92), respectively, which were significantly higher than those in the control group (p<0.05). The serum C-reactive protein and tumor necrosis factor alpha in the observation group were significantly lower than those in the control group at 1 d, 3 d and 7 d after operation (p<0.05). Midazolam has a good sedative effect in the elderly patients with acute cerebral infarction, reducing brain oxygen metabolism and stabilizing hemorheology.