Effect of microRNA‑370 on coronary atherosclerosis and its underlying mechanism

Abstract

As a global health problem, cardiovascular disease threatens the lives of human beings. It has been reported that microRNAs (miRs) are important in regulating coronary atherosclerosis. In the present study, the expression levels of miR-370 in peripheral blood mononuclear cells of patients with coronary atherosclerosis were significantly increased compared with healthy patients, as demonstrated by reverse transcription-quantitative polymerase chain reaction analysis. Additionally, the target of miR-370 was predicted as Forkhead Box 1 (FOXO1) with bioinformatics, and was confirmed by a dual luciferase assay. The mRNA and protein expression levels of FOXO1 were inhibited by miR-370. Furthermore, the invasion and proliferation of human umbilical vein endothelial cells were promoted by miR-370 via inhibiting the expression of FOXO1. The results obtained in the present study demonstrated that miR-370 served an important role in regulating coronary atherosclerosis via targeting FOXO1. The present data also indicated that miR-370 may be a promising molecular target for treating coronary atherosclerosis.

Circular RNA circ_0010283 regulates the viability and migration of oxidized low‑density lipoprotein‑induced vascular smooth muscle cells via an miR‑370‑3p/HMGB1 axis in atherosclerosis

“…These results suggested that circ_0010283 may regulate the progression of atherosclerosis by sponging miR-370-3p. In addition, the inhibitory role of miR-370-3p in atherosclerosis progression was observed, which was consistent with previous studies (19,32).…”

“…Emerging evidence has revealed a core position of miRNAs in the regulation of atherosclerosis progression (14,15). miR-370-3p has been reported to be associated with a number of human diseases including acute pneumonia, cerebral aneurysm and tuberculosis (16)(17)(18), and a previous study has demonstrated that miR-370-3p regulates coronary atherosclerosis progression (19). However, the Circular RNA circ_0010283 regulates the viability and migration of oxidized low-density lipoprotein-induced vascular smooth muscle cells via an miR-370-3p/HMGB1 axis in atherosclerosis precise mechanism of miR-370-3p in regulating atherosclerosis progression remains to be studied.…”

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Polychlorinated Biphenyl Coexposure Alters the Expression Profile of MicroRNAs in the Liver Associated with Atherosclerosis

“…The mechanism of TCDD-and PCB-induced atherosclerosis has been well characterized by many studies [21,23,39,40]. Emerging data continue to demonstrate the participation of miRNAs in atherosclerosis [41][42][43] and in biological responses induced by environmental pollutants [44][45][46]. However, there have been no previous reports on miRNA expression in TCDD-and PCB-induced atherosclerosis.…”

Profiling and functional analysis of differentially expressed circular RNAs in high glucose‐induced human umbilical vein endothelial cells

“…Among its putative target miRNAs, miR‐370 is the one with close association with the proliferation, apoptosis, and angiogenesis of vascular endothelial cells. The proliferation of HUVECs and formation of capillary‐like structures can be promoted by miR‐370 via inhibiting the expression of forkhead box 1 and maternally expressed gene 3 . But in retinal capillary endothelial cell, miR‐370 was reported to induce growth inhibition and apoptosis by reducing the expression of kinase insert domain‐containing receptor gene .…”