Effect of Micronutrient-Fortified Milk on Zinc Intake and Plasma Concentration in Adolescent Girls

Mendez‐Estrada, Rosa Olivia; Galdámez, Karina; Grijalva, Maria Isabel; Quihui, Luis; Garcı́a, Hugo S.; Barca, Ana Ma. Calderón de la

doi:10.1080/07315724.2012.10720467

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…The characteristics of the 24 adolescent girls in this intervention were almost the same of those reported in our former study [5], except by the mean age (14.1 instead of 15.1 years old). However, there were no differences in the mean plasma zinc levels of adolescent girls in the current study, after the 27 days intervention, while in our former study zinc levels increased after drinking fortified milk in the same period.…”

Section: Discussionsupporting

confidence: 60%

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Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels

et al. 2014

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Zinc homeostasis is achieved after intake variation by changes in the expression levels of zinc transporters. The aim of this study was to evaluate dietary intake (by 24-h recall), absorption, plasma zinc (by absorption spectrophotometry) and the expression levels (by quantitative PCR), of the transporters ZIP1 (zinc importer) and ZnT1 (zinc exporter) in peripheral white blood cells from 24 adolescent girls before and after drinking zinc-fortified milk for 27 day. Zinc intake increased (p < 0.001) from 10.5 ± 3.9 mg/day to 17.6 ± 4.4 mg/day, and its estimated absorption from 3.1 ± 1.2 to 5.3 ± 1.3 mg/day. Mean plasma zinc concentration remained unchanged (p > 0.05) near 150 µg/dL, but increased by 31 µg/dL (p < 0.05) for 6/24 adolescents (group A) and decreased by 25 µg/dL (p < 0.05) for other 6/24 adolescents (group B). Expression of ZIP1 in blood leukocytes was reduced 1.4-fold (p < 0.006) in group A, while for the expression of ZnT1 there was no difference after intervention (p = 0.39). An increase of dietary zinc after 27-days consumption of fortified-milk did not increase (p > 0.05) the plasma level of adolescent girls but for 6/24 participants from group A in spite of the formerly appropriation, which cellular zinc uptake decreased as assessed by reduction of the expression of ZIP1.

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Section: Discussionsupporting

confidence: 60%

“…We found previously that zinc-fortified milk was effective in increasing both, intake and plasma zinc levels of adolescent girls from the northwest area of the country [5]. Under basal conditions, 35% of the studied adolescents did not meet their zinc requirements and were facing a borderline deficiency.…”

Section: Introductionmentioning

confidence: 97%

Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels

et al. 2014

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Fortification of staple foods with zinc for improving zinc status and other health outcomes in the general population

Shah

Sachdev

Gera

et al. 2016

Cochrane Database of Systematic Reviews

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Zinc Absorption from Fortified Milk Powder in Adolescent Girls

Mendez‐Estrada

Hambidge

Baker

et al. 2015

Biol Trace Elem Res

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Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determine the impact of micronutrient-fortified milk intake during 27 days on Zn absorption in adolescent girls from northwest Mexico. Therefore, Zn absorption was evaluated in 14 healthy adolescent girls (14.1 years old) with adequate plasma Zn levels, before and after 27 days of fortified Zn milk intake. Fractional Zn absorption (FZA) was calculated from urinary ratios of stable isotopic Zn tracers administered orally and intravenously on days 0 and 27, and total absorbed Zn (TZA) was calculated. At the beginning, Zn intake was 6.8 ± 0.85 mg/d (mean ± SE), and 50 % of the adolescent girls did not achieve their requirement (7.3 mg/d). Additionally, FZA was negatively correlated with Zn intake (r =-0.61, p = 0.02), while TZA (1.06 mg/d) was insufficient to cover the physiologic requirements of adolescent girls (3.02 mg/d). At the end of the intervention, all the girls reached the Zn intake recommendation and TZA, 3.09 mg/d, which was enough to meet the physiological requirement for 57 % of the adolescent girls. Therefore, the low Zn intake and the Zn status of adolescent girls were positively impacted by Zn-fortified milk intake and its good absorption rate.

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Effect of Micronutrient-Fortified Milk on Zinc Intake and Plasma Concentration in Adolescent Girls

Abstract: Fortified milk intake is effective in increasing both intake and plasma zinc levels of adolescent Mexican girls; therefore, it could be an adequate strategy for zinc deficiency prevention or correction among adolescent girls.

Cited by 6 publications

References 23 publications

Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels

Zinc Fortification Decreases ZIP1 Gene Expression of Some Adolescent Females with Appropriate Plasma Zinc Levels

Fortification of staple foods with zinc for improving zinc status and other health outcomes in the general population

Zinc Absorption from Fortified Milk Powder in Adolescent Girls

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