Effect of microencapsulated Bacillus subtilis strain CBD2-fermented grain on loperamide-induced constipation in mice

Kim, Bae Jin; Jung, Hyun-Sam; Jeong, Yoo Seok; Yang, Su Jin; Hong, Joo-Heon

doi:10.1007/s13765-016-0182-7

Appl Biol Chem

2016

DOI: 10.1007/s13765-016-0182-7

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Effect of microencapsulated Bacillus subtilis strain CBD2-fermented grain on loperamide-induced constipation in mice

Bae Jin Kim

Hyun-Sam Jung

Yoo Seok Jeong

et al.

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Cited by 5 publications

References 56 publications

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In vivo functional effects of Weissella confusa VP30 exopolysaccharides on loperamide-induced constipation in rats

Park¹,

Lee

Yang³

et al. 2022

Food Sci Biotechnol

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In our previous work, we characterized the in vitro biofunctionality and evaluated the biosafety of exopolysaccharide (EPS)-producing Weissella confusa VP30 (VP30), newly isolated from healthy children's feces.Since the puri ed EPS (pEPS) from fermented milk with VP30 (VP30-EPS) showed signi cant water holding capacity, it was theorized that its consumption would relieve constipation. In this work, the in vivo functionalities of VP30-EPS and pEPS were evaluated for their effect on constipation using an experimental constipated rat model. Rats were randomly divided into four groups: (i) negative control (PBS administered normal group), (ii) loperamide treated positive control (constipation group), (iii) constipation with loperamide plus VP30-EPS (1 g/kg) and (iv) constipation with loperamide plus pEPS (0.6 g/kg) groups. Loperamide treatment induced animal constipation and signi cantly reduced the frequency of defecation, intestinal transit ratio, and water content of feces. However, all four fecal parameters were improved in both the loperamide plus VP30-EPS and pEPS administered groups as compared to the loperamide treated positive control group. No signi cant changes in dietary intake or serum hepatocellular necrosis maker levels were observed in any experimental group. These results suggest that the addition of VP30-EPS or pEPS potentially improves the functional laxative effects of commercial products. No other published research relating in vivo functional effects of EPS from Weissella spp. on constipation could be identi ed. This study suggests the possibility that VP30-EPS and pEPS can be applied to fermented and/or functional foods to relieve constipation.

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In vivo functional effects of Weissella confusa VP30 exopolysaccharides on loperamide-induced constipation in rats

Park¹,

Lee

Yang³

et al. 2022

Food Sci Biotechnol

View full text Add to dashboard Cite

show abstract

Plant growth-promoting rhizobacteria used in South Korea

et al. 2018

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Many bacteria found in the rhizosphere provide contribution for the host plant's growth and protection that are known as plant growth-promoting rhizobacteria (PGPR). Plant-microbe interactions in the rhizosphere are important factors in determining the health of plants. Research for commercialization of these PGPR as an alternative to the use of chemical fertilizers for a more environmentally friendly treatment is continuously being improved. In this review, we discuss the essential traits that rhizobacteria must possess for them to be considered PGPR and report the bacterial species that exhibit these essential plant growth-promoting activities and which are approved for use by the South Korean regulations.

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Improvement of S-allyl-L-cysteine content, probiotic properties and constipation prevention effect of black garlic by the lactic acid bacteria fermentation

Chen

et al. 2022

Process Biochemistry

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Effect of microencapsulated Bacillus subtilis strain CBD2-fermented grain on loperamide-induced constipation in mice

Cited by 5 publications

References 56 publications

In vivo functional effects of Weissella confusa VP30 exopolysaccharides on loperamide-induced constipation in rats

In vivo functional effects of Weissella confusa VP30 exopolysaccharides on loperamide-induced constipation in rats

Plant growth-promoting rhizobacteria used in South Korea

Improvement of S-allyl-L-cysteine content, probiotic properties and constipation prevention effect of black garlic by the lactic acid bacteria fermentation

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