Effect of microecological preparation supplementation on woman with polycystic ovary syndrome

Abstract

Background:Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. PCOS not only affects female fertility, but is also associated with a variety of metabolic diseases, such as type 2 diabetes. Microecological preparations include probiotics, prebiotics, and synbiotics, and a number of studies have shown its advantages in reducing cardiovascular and cerebrovascular diseases in patients with PCOS, however, no meta-analysis has been performed to confirm that. Herein, we describe the protocol of a proposed study based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines that aims to systematically evaluate the efficacy and safety of microecological preparation supplementation in woman with PCOS.Methods:Two researchers will search 9 electronic databases (PubMed, Cochrane Library, Embase, ClinicalTrails, China National Knowledge Infrastructure, Sino Med, ScienceDirect, VIP, and Wanfang Data databases) to identify all studies that meet the inclusion criteria and were published before November 1, 2018. After information extraction and methodological quality evaluation, we will use RevMan software (version 5.3) to synthesize the data. The primary outcomes will be fasting blood glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and very low-density lipoprotein cholesterol (VLDL-c).Results:This study will provide a high-quality synthesis of existing evidence on the effect and safety of microecological preparation supplementation on reducing cardiovascular risk of woman with PCOS.Conclusion:This study will determine if microecological preparation supplementation is an effective and safe intervention on reducing cardiovascular risk of woman with PCOS.Registration:PROSPERO (registration number: CRD42018108403).

Exploration of the Relationship Between Gut Microbiota and Polycystic Ovary Syndrome (PCOS): a Review

“…No adverse effects of probiotic supplementation were observed [118]. A meta-analysis by Zhang [119] showed that probiotics can reduce total cholesterol, triglycerides and low-density lipoprotein cholesterol levels, in-crease high-density lipoprotein cholesterol and consequently reduce the long-term cardiovascular risk of PCOS patients. But they also pointed out the limitations of current studies on probiotics supplementation, including the fact that the probiotics used in each study varied widely and no standard dosages were used, points which will need to be addressed in future studies.…”

Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta‐Analysis

“…Microecological preparations, such as probiotics, prebiotics, and synbiotics, comprise one of the safe approaches to improve the composition of gut microbiota in humans [11] that positively regulate inflammatory bowel disease [12], infection by Clostridium difficile [13], immune responses [14], and diabetes [15]. Probiotics reduce body weight, BMI, and fat percentage in overweight or obese individuals [16].…”