Effect of Microalgae Arthrospira on Biomarkers of Glycemic Control and Glucose Metabolism: A Systematic Review and Meta-analysis

Ghanbari, Fahimeh; Amerizadeh, Atefeh; Behshood, Parisa; Moradi, Sajjad; Asgary, Sedigheh

doi:10.1016/j.cpcardiol.2021.100942

Cited by 8 publications

(4 citation statements)

References 41 publications

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“…Hence, suppression of NADPH oxidase activity with PCB or whole spirulina has the potential to alleviate adipocyte insulin resistance [ 299 ]. This rationalizes the insulin sensitizing effects observed when rodent or human type 2 diabetics are fed spirulina [ 304 , 305 ]. It is also reasonable to expect that the downstream impact of oxidants on JNK/IKKβ might be blunted to some degree by Nrf2-inducible enzymes; consistent with this possibility, lipoic acid supplementation has been reported to achieve modest dose-dependent improvements in glycemic control in type 2 diabetics [ 306 ].…”

Section: Some Agents Reducing Risk For Complications May Also Aid Ins...mentioning

confidence: 70%

Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

McCarty

DiNicolantonio²,

O’Keefe³

2022

CIMB

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Oxidative and dicarbonyl stress, driven by excess accumulation of glycolytic intermediates in cells that are highly permeable to glucose in the absence of effective insulin activity, appear to be the chief mediators of the complications of diabetes. The most pathogenically significant dicarbonyl stress reflects spontaneous dephosphorylation of glycolytic triose phosphates, giving rise to highly reactive methylglyoxal. This compound can be converted to harmless lactate by the sequential activity of glyoxalase I and II, employing glutathione as a catalyst. The transcription of glyoxalase I, rate-limiting for this process, is promoted by Nrf2, which can be activated by nutraceutical phase 2 inducers such as lipoic acid and sulforaphane. In cells exposed to hyperglycemia, glycine somehow up-regulates Nrf2 activity. Zinc can likewise promote glyoxalase I transcription, via activation of the metal-responsive transcription factor (MTF) that binds to the glyoxalase promoter. Induction of glyoxalase I and metallothionein may explain the protective impact of zinc in rodent models of diabetic complications. With respect to the contribution of oxidative stress to diabetic complications, promoters of mitophagy and mitochondrial biogenesis, UCP2 inducers, inhibitors of NAPDH oxidase, recouplers of eNOS, glutathione precursors, membrane oxidant scavengers, Nrf2 activators, and correction of diabetic thiamine deficiency should help to quell this.

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Section: Some Agents Reducing Risk For Complications May Also Aid Ins...mentioning

confidence: 70%

Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

McCarty

DiNicolantonio²,

O’Keefe³

2022

CIMB

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“…Arthrospira platensis is widely recognized for its therapeutic benefits in conditions such as arthritis, cardiovascular diseases, and diabetes ( 36 – 38 ). Microalgal biomass enriched with microelement ions provides a highly bioavailable source of minerals to animals and can partially substitute the traditionally used inorganic salts as the primary source of microelements ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions improves insulin sensitivity and reduces systemic inflammation in equine metabolic affected horses

Tomal,

Szłapka-Kosarzewska,

Mironiuk

et al. 2024

Front. Endocrinol.

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Equine metabolic syndrome (EMS) is a critical endocrine condition in horses, characterized by hyperinsulinemia, hyperlipidemia, and insulin resistance, posing a significant threat to their health. This study investigates the efficacy of supplementing EMS-affected horses with Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions using biosorption process in improving insulin sensitivity and glucose tolerance, reducing inflammation, and mitigating obesity-related fat accumulation. Our results demonstrate that Arthrospira supplementation reduces baseline insulin and glucose levels, contributing to decreased adipose tissue inflammation. Furthermore, Arthrospira supplementation results in a decrease in body weight and improvements in overall body condition scores and cresty neck scores. Additionally, administration of Arthrospira leads to reduced levels of triglycerides and aspartate aminotransferase, indicating a decrease in hepatic adiposity and inflammation. These findings suggest that Arthrospira, enriched with essential micro- and macroelements, can be an advanced feed additive to enhance insulin sensitivity, promote weight reduction, and alleviate inflammatory processes, thereby improving the overall condition of horses affected by EMS. The use of Arthrospira as a feed additive has the potential to complement conventional management strategies for EMS.

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“…Microalgae’s prebiotic polysaccharides contribute to conserving the intestine’s integrity, and its phenolics may have a part by directly impacting gut microbiota, or concomitantly by the intervention of the endogenous antioxidant defense system [ 214 ]. In this respect, a meta-analysis of 7 clinical and 27 preclinical studies, about the effects of Arthrospira (Spirulina) supplementation on glucose metabolism and glycemic control showed that in clinical studies it decreased fasting blood glucose, triglycerides, and total cholesterol levels, and increased HDL-C for patients with T2DM, but it did not have an impact on HbA1c, while in animal studies it decreased fasting blood glucose and HbA1c [ 215 ]. However, further studies are needed to fully elucidate their potential benefit on glucose control in T2DM.…”

Section: Nutraceuticals and Supplementsmentioning

confidence: 99%

Comprehensive Approach to Medical Nutrition Therapy in Patients with Type 2 Diabetes Mellitus: From Diet to Bioactive Compounds

et al. 2023

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In the pathogenesis of type 2 diabetes mellitus (T2DM), diet plays a key role. Individualized medical nutritional therapy, as part of lifestyle optimization, is one of the cornerstones for the management of T2DM and has been shown to improve metabolic outcomes. This paper discusses major aspects of the nutritional intervention (including macro- and micronutrients, nutraceuticals, and supplements), with key practical advice. Various eating patterns, such as the Mediterranean-style, low-carbohydrate, vegetarian or plant-based diets, as well as healthy eating plans with caloric deficits have been proven to have beneficial effects for patients with T2DM. So far, the evidence does not support a specific macronutrient distribution and meal plans should be individualized. Reducing the overall carbohydrate intake and replacing high glycemic index (GI) foods with low GI foods have been shown as valid options for patients with T2DM to improve glycemic control. Additionally, evidence supports the current recommendation to reduce the intake of free sugars to less than 10% of total energy intake, since their excessive intake promotes weight gain. The quality of fats seems to be rather important and the substitution of saturated and trans fatty acids with foods rich in monounsaturated and polyunsaturated fats lowers cardiovascular risk and improves glucose metabolism. There is no benefit of supplementation with antioxidants, such as carotene, vitamins E and C, or other micronutrients, due to the lack of consistent evidence showing efficacy and long-term safety. Some studies suggest possible beneficial metabolic effects of nutraceuticals in patients with T2DM, but more evidence about their efficacy and safety is still needed.

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Effect of Microalgae Arthrospira on Biomarkers of Glycemic Control and Glucose Metabolism: A Systematic Review and Meta-analysis

Cited by 8 publications

References 41 publications

Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

Arthrospira platensis enriched with Cr(III), Mg(II), and Mn(II) ions improves insulin sensitivity and reduces systemic inflammation in equine metabolic affected horses

Comprehensive Approach to Medical Nutrition Therapy in Patients with Type 2 Diabetes Mellitus: From Diet to Bioactive Compounds

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