Effect of MgO contents on the mechanical properties and biological performances of bioceramics in the MgO–CaO–SiO2 system

Abstract

The aim of this research was to investigate the effect of the chemical composition on the mechanical properties, bioactivity, and cytocompatibility in vitro of bioceramics in the MgO-CaO-SiO(2) system. Three single-phase ceramics (merwinite, akermanite and monticellite ceramics) with different MgO contents were fabricated. The mechanical properties were tested by an electronic universal machine, while the bioactivity in vitro of the ceramics was detected by investigating the bone-like apatite-formation ability in simulated body fluid (SBF), and the cytocompatibility was evaluated through osteoblast proliferation and adhesion assay. The results showed that their mechanical properties were improved from merwinite to akermanite and monticellite ceramics with the increase of MgO contents, whereas the apatite-formation ability in SBF and cell proliferation decreased. Furthermore, osteoblasts could adhere, spread and proliferate on these ceramic wafers. Finally, the elongated appearance and minor filopodia of cells on merwinite ceramic were more obvious than the other two ceramics.

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

“…A similar worm‐looking morphology of HA is previously reported by Chen et al that was formed on the surface of MgO–CaO–SiO 2 bioglass. According to the SEM observations, HA formation on BG‐5/5 surface during its immersion in SBF solution was in agreement with FTIR and XRD results.…”

Characterization of novel akermanite:poly-ϵ-caprolactone scaffolds for human adipose-derived stem cells bone tissue engineering

“…It is well established that in aqueous environments, synthetic apatites degrade overtime through physiochemical dissolution (Gaalen et al ., ), and depending on the concentration of the biomaterial, this may result in decreased biocompatibility (Bouler et al ., ; Chen et al ., ; Chen et al ., ). The PCL phase of the composite is poorly water‐soluble, has a melting temperature of 58 to 63 °C (Fabbri et al ., ) and degrades by surface hydrolysis of ester linkages with release of caproic acid, which has also been demonstrated to be cytotoxic at high concentrations (Sarasam et al ., ).…”

“…In the literature, multi‐phase ceramics containing a mixture of akermanite, merwinite and dicalcium silicate have been recently studied (Chen et al ., ) as potential osteogenic materials. It should be noted that merwinite was demonstrated to promote osteogenesis and bone regeneration (Ou et al ., ; Chen et al ., ) and was carefully removed from this study for the purpose of observing behaviour of a pure akermanite phase. Further investigations should be conducted to investigate whether the merwinite phase and related compositions have similar biocompatibility and ability to modulate osteogenic differentiation as akermanite.…”

Intriguing role of TiO2 in glass‐ceramics: Bioactive and magneto‐structural properties

“…The samples were immersed in SBF into airtight polyethylene containers maintained at 37°C inside an incubator for various time durations. In literature, different volume of SBF has been taken for different surface area or weight of the immersed sample for in vitro studies . Based on our earlier study, the volume of SBF for each sample was taken according to weight by volume ratio 0.02 g/mL .…”

“…In literature, different volume of SBF has been taken for different surface area or weight of the immersed sample for in vitro studies. 16,[18][19][20] Based on our earlier study, the volume of SBF for each sample was taken according to weight by volume ratio 0.02 g/mL. 16 pH of each SBF specimen was recorded regularly.…”