Effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor

Abstract

Objective: To explore the effect of metronidazole combined with autolytic debridement for the management of malignant wound malodor. Methods: Patients with malignant wounds who underwent dressing change at a wound outpatient clinic from September 2016 to February 2019 were randomized to an observation group (36 patients) or a control group (37 patients). The observation group was treated with metronidazole combined with debridement gel while the control group received wet dressing therapy combined with silver sulfadiazine. Malodor control was compared between the two groups from treatment initiation to days 3 and 12 after dressing change, and the social impact scale was used to compare stigma caused by malodor between the groups before and after treatment. Results: The observation group had significantly superior malodor control on days 3 and 12 after dressing change compared with the control group. There was no difference in stigma between the two groups before treatment, but stigma in the observation group was significantly lower than that in the control group after treatment. Conclusion: Metronidazole combined with autolytic debridement can effectively reduce the malodor of cancerous wounds while controlling infection, and alleviate patient stigma caused by malodor.

Caring for Patients With Malignant Fungating Wounds

“…The use of antimicrobial products such as silver-coated dressings with octenidine dihydrochloride was examined in 2 studies; both reported that these additives reduced malodor associated with MFW 36,37. Peng and Dai42 conducted a randomized controlled study to examine the efficacy of combination of metronidazole and debridement gel in dressing in 36 patients with MFW. They reported significantly reduced malodor at treatment days 3 and 12 when compared to the patients using silver wet dressings.…”

“…Most focused on local therapies (dressings), used with or without systemic interventions such as antibiotics. Three studies were case studies32–35 and 3 were reports of original research evaluating the effects of topical or systematic therapies on pain, malodor, exudate, and bleeding 7,36–42…”

“…Three studies were case studies [32][33][34][35] and 3 were reports of original research evaluating the effects of topical or systematic therapies on pain, malodor, exudate, and bleeding. 7,[36][37][38][39][40][41][42] Topical Therapies…”

Construction of an Algorithm of Conduct of Signs and Symptoms in Malignant Neoplastic Wounds in Adults

“…, being applied directly to the wound bed, or even used systemically. However, for its use, a medical prescription is necessary, which can make it difficult for nurses to provide assistance if the institution does not have a defined protocol that facilitates access to the medication 19,20 .…”

Construção De Algoritmo De Condutas De Sinais E Sintomas Nas Feridas Neoplásicas Malignas Em Adultos

“…Entretanto, para sua utilização, faz-se necessária a prescrição médica, o que pode dificultar a assistência do enfermeiro caso a instituição não tenha um protocolo definido que facilite seu acesso ao medicamento 19,20 .…”