Effect of metoclopramide on ejaculatory threshold in a group of premature ejaculators

Abstract

The exact etiology of premature ejaculation is not known. Recent data using rats has demonstrated that dopamine agonists can lower ejaculatory thresholds while pretreatment with substituted benzamides will block that effect. Metoclopramide, the only drug in the group available in the United States, and a placebo were given to 12 premature ejaculators in a double-blind crossover fashion. Couples had intercourse on Wednesdays and Saturdays for four weeks. Ejaculatory latencies were recorded separately by husbands and wives on a 1-5 scale. There was no statistical difference in perception of ejaculatory latency between metoclopramide-and placebo-treated coiti although the P values for the wives' perception was ,067. An added observation was that approximately 80% of premature ejaculators had palmar hyperhidrosis. It is conjectured that early ejaculation and palmar hidrosis are manifestations of sympathetically mediated "overreactivity ."

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

“…These reports comprised the use of anesthetic ointments, 12,26,27,[29][30][31][32][33][34][35][36][37] neuroleptics, 20,22,[38][39][40][41][42] monoamine-oxidase inhibitors, 16,43 sympatholytic drugs, 18,19,[44][45][46] antibiotics, 47,48 and a group of miscellaneous agents 13,14,21,[49][50][51] (Table 1). Between 1973 and 2003, there have been 35 studies 15,17,23-25,60-79,80,81 on daily treatment with clomipramine, a tricyclic antidepressant, and on SSRIs (Table 2).…”

“…[33][34][35]67,76,85 Baseline periods ranged from 1 68,69 or 2 26,27 to mostly 4 weeks. 49,57,65,[77][78][79][80]89 In some studies, a certain number of intercourses 41,60,74,81 was taken as baseline measurement.…”

The Psychobiology of Emotions

“…Other researchers have postulated that hyperhidrosis patients' poor psychosocial adjustment may manifest itself in other psychophysiological disorders. For example, Wabrek (1984) observed that 80% of a sample of males being treated for premature ejaculation also had palmar hyperhidrosis.…”