Effect of methylphenidate at different doses on new bone formation with rapid maxillary expansion: A micro‐CT and histomorphometric study in rats

Abstract

Posterior crossbite is one of the most common craniofacial disorders in late-mixed or early permanent dentition. The prevalence of posterior crossbite in children was reported between 4% and 23%. 1 Rapid maxillary expansion (RME) is the gold standard in the treatment of maxillary transversal discrepancies. With the separation of the midpalatal suture in RME protocol, the arch length and the width of the maxilla are increased. Sutural expansion is followed by the active new bone formation at the midpalatal suture. 2 Hence, the factors

Effects of methylphenidate on femoral bone growth in male rats

“…No statistically significant difference was observed between the MP-exposed rats and the control group in respect of the number of osteoclasts. 12 MP-induced deficiencies in bone growth, mineralization, and strength may be based on the direct effects of MP on bone as well as the reduced weight gain. An in vitro study provides evidence supporting the direct impact of MP on bone tissue.…”

“…No statistically significant difference was observed between the MP-exposed rats and the control group in respect of the number of osteoclasts. 12…”

“…11 Another study revealed that MP adversely affected new bone formation in the premaxillary suture by decreasing osteoblastic activity in rats. 12 Upon reviewing existing literature, it becomes evident that while the inhibitory effect of MP on bone growth and mineralization is recognized, there is a notable absence of studies focusing on the immunohistochemical exploration of cellular attributes and mineralization within the growth plate. Furthermore, there appears to be a lack of investigations that quantitatively assess the volume of the growth plate and femoral bone.…”

“…11 Another study revealed that MP adversely affected new bone formation in the premaxillary suture by decreasing osteoblastic activity in rats. 12…”