2023
DOI: 10.1097/md.0000000000032743
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Effect of methylene blue on hemodynamic response in the early phase of septic shock: A case series

Abstract: Rationale: Methylene blue (MB) has been used to increase blood pressure in septic shock, acting on the activity of guanylate cyclase and nitric oxide synthase. Patience concerns: The aim of this study is to demonstrate the benefit of MB in early phase of septic shock. Diagnoses: We report 6 cases of patients with septic shock with up to 72 hours of evolution. Interventions: We used MB after fluid… Show more

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Cited by 5 publications
(6 citation statements)
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“…In the setting of sepsis, in ammatory cytokines have been theorized to suppress the cortisol response or compete with intracellular glucocorticoid receptors, resulting in peripheral tissue resistance and eventual vascular collapse [37,38]. Low-dose corticosteroid therapy has been utilized in septic shock patients to enhance the vascular contractile response to pressor agents [39]. The utility of steroids was not explicitly described in any of the included studies, except for that of Ibarra-Estrada et al [25].…”
Section: Discussionmentioning
confidence: 99%
“…In the setting of sepsis, in ammatory cytokines have been theorized to suppress the cortisol response or compete with intracellular glucocorticoid receptors, resulting in peripheral tissue resistance and eventual vascular collapse [37,38]. Low-dose corticosteroid therapy has been utilized in septic shock patients to enhance the vascular contractile response to pressor agents [39]. The utility of steroids was not explicitly described in any of the included studies, except for that of Ibarra-Estrada et al [25].…”
Section: Discussionmentioning
confidence: 99%
“…Treatment includes uid replacement, infusion of vasopressors, and administration of antibiotics within the rst hour [1]; these treatments are associated with low-dose corticosteroids in refractory cases [6], but mortality remains high, especially in developing countries. Studying new medications that help maintain hemodynamic stability until the antibiotic acts and combats the infectious focus is necessary [7].…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have proposed that MB can treat circulatory shock secondary to vasoplegia via nitric oxide (NO) [7,8,[10][11][12][13][14][15]. In a rat model of endotoxemia induced by lipopolysaccharide (LPS) and treated with MB, complete prevention of leukocyte rolling and adhesion to the endothelium was observed, resulting in a consistent systemic blood pressure response and a decreased need for vasoactive medications [16].…”
Section: Introductionmentioning
confidence: 99%
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