Effect of methyl cellulose on gelation behavior and drug release from poloxamer based ophthalmic formulations

Developing Transdermal Applications of Ketorolac Tromethamine Entrapped in Stimuli Sensitive Block Copolymer Hydrogels

“…On the other hand, rheology is a useful technique to characterize the structure strength of semisolid systems and predict their behavior for topical uses (29). Concretely, viscosity of vehicles may play an important role in controlling the release and skin permeation of drugs (30). Rheological measurements indicated how much a sample deforms or how fast it flows by means of stressing the sample.…”

Evaluation of β-cyclodextrin-modified gemini surfactant-based delivery systems in melanoma models

“…In the formulation development process, methylcellulose, a carbohydrate polymer, was used to prevent aggregation of the nanoparticles. Methylcellulose gel is a frequently used pharmaceutical excipient, [30][31][32] which can form interpenetrating polymer network microspheres providing slow release of various drugs. 31 While the particle size increased to 250 nm, it remained in the acceptable range for intracellular penetration and maintained its stability in the presence of cell culture medium.…”

“…Methylcellulose gel is a frequently used pharmaceutical excipient, [30][31][32] which can form interpenetrating polymer network microspheres providing slow release of various drugs. 31 While the particle size increased to 250 nm, it remained in the acceptable range for intracellular penetration and maintained its stability in the presence of cell culture medium. The assembly of the Mel-NPs resulted in similar sized nanoparticles to another poorly soluble compound, an 1,5-diaryl-3-oxo-1,4-pentadienyl curcumin analog.…”

Hydrogel Biomaterials for Application in Ocular Drug Delivery

“…Methylcellulose can also be added to a formulation to adjust its gelation behavior. This was investigated by Dewan et al (2015) in a study where methylcellulose of varying molecular weights were added to Poloxamer 407 (PM), a polymer previously investigated for the delivery of various drugs to the eye. However, when used in these formulations, PM is diluted by the lacrimal fluid of the eye and loses its ability to form a gel.…”