Effect of methotrexate upon antigen‐induced arthritis of the rabbit temporomandibular joint

Rafayelyan, Smbat; Meyer, Philipp; Radlanski, Ralf J.; Minden, Kirsten; Jost‐Brinkmann, Paul‐Georg; Präger, Thomas Michael

doi:10.1111/jop.12265

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…After antigen injection has been recognized as a successful and reliable method for inducing arthritis of the knee joints in rabbits, the antigen-induced arthritis (AIA) in TMJ of the rabbit has been chosen by numerous researchers. 31 Arthritis was induced with an intra-articular administration of ovalbumin in 10-week-old male New Zealand white rabbits. Antigen-treated joints demonstrated severe arthritis symptoms, involving mononuclear cell infiltration, synovial lining, villous hyperplasia, and pannus formation, which maintain from 5 to 55 days post-operation.…”

Section: Animal Models Of Tmdmentioning

confidence: 99%

Animal Models of Temporomandibular Disorder

Xiang

Tao

Liao

et al. 2021

JPR

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Temporomandibular disorders (TMD) are a group of diseases in the oral and maxillofacial region that can manifest as acute or chronic persistent pain, affecting millions of people worldwide. Although hundreds of studies have explored mechanisms and treatments underlying TMD, multiple pathogenic factors and diverse clinical manifestations make it still poorly managed. Appropriate animal models are helpful to study the pathogenesis of TMD and explore effective treatment measures. At present, due to the high cost of obtaining large animals, rodents and rabbits are often used to prepare TMD animal models. Over the past decade, various animal models have been intensively developed to understand neurobiological and molecular mechanisms of TMD, and seek effective treatments. Although these models cannot carry out all clinical features, they are valuable in revealing the mechanisms of TMD and creating curative access. Currently, there are multitudinous animal models of TMD research. They can be constructed in different means and summarized into four ways according to the various causes and symptoms, including chemical induction (intra-articular injection of ovalbumin, collagenase, formalin, vascular endothelial growth factor, intramuscular injection of complete Freund's adjuvant, etc.), mechanical stress stimulation (passive mouth opening, change of chewing load), surgical operation (partial disc resection, joint disc perforation) and psychological stress induction. Here, we summarize and discuss different approaches of animal models for determining neurophysiological and mechanical mechanisms of TMD and assess their advantages and limitations, respectively.

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Section: Animal Models Of Tmdmentioning

confidence: 99%

Animal Models of Temporomandibular Disorder

Xiang

Tao

Liao

et al. 2021

JPR

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“…Methotrexate is the only medication with significant evidence in the treatment of TMJ arthritis [57] and is usually first line in practice for JIA with TMJ involvement. Weekly intramuscular injection of methotrexate has been shown to decrease cartilage degeneration in rabbits with antigen-induced arthritis but failed to eliminate arthritis completely [64]. Furthermore, in a cross-sectional study, Ince et al demonstrated that methotrexate therapy may minimize TMJ destruction in polyarticular JIA.…”

Section: Conventional Dmardsmentioning

confidence: 99%

Comprehensive Management of Rheumatic Diseases Affecting the Temporomandibular Joint

2021

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The temporomandibular joint (TMJ) is a synovial joint and thus is vulnerable to the afflictions that may affect other joints in the fields of rheumatology and orthopedics. Too often temporomandibular complaints are seen strictly as dental or orofacial concerns. Similarly, patients with known rheumatic disease may not have their TMJs included in routine screening and monitoring protocols. The purpose of this review is to highlight the rheumatic conditions likely to affect the TMJ and outline medical and surgical management in these patients with a focus on the need for continued patient reassessment and monitoring.

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“…Araştırmada, MTX'in sistemik olarak uygulanmasının, tavşan TME'nin enflamatuar süreci üzerinde olumlu etkiye sahip olduğu ancak artrit belirtilerinin tamamen ortadan kaldırılamadığı bildirilmiştir. 37 Araştırmamızda bu çalışmaların 7tepeklinik sonuçlarından farklı olarak MTX kullanan ve kullanmayan olgular arasında ağrı, ses, kısıtlı hareket, retrognati ve anterior open-bite görülme oranları açısından istatistiksel olarak anlamlı bir farklılık bulunmamıştır. TME tutulumunun değerlendirilmesinde araştırmamızda, TME'nin klinik muayene bulguları değerlendirilmiş, radyografik olarak bir değerlendirme yapılmamıştır.…”

Section: Gereç Ve Yöntemunclassified

Oral health and temporomandibular joint involvement of patient with juvenile idiopathic arthritis

Giray¹,

Durmuş²,

Ertuğral³

et al. 2018

Yeditepe J Dent

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Bu çalışmanın amacı, İstanbul'daki büyük bir eğitim-araştırma hastanesine gelen ve JIA teşhisi konmuş çocuk hastaların ağız ve diş sağlığı durumlarını ve TME tutulumlarını değerlendirmek ve yaş ile cinsiyet eşleşmesi yapılmış sağlıklı çocuklar ile karşılaştırmaktır. Gereç ve Yöntem:Araştırmada, JIA teşhisi konmuş 35 çocuk hasta ile yaş ve cinsiyet eşleşmesi yapılmış 35 sağlıklı çocuk dahil edilmiştir. Yapılan muayenede demografik verilerin yanında çürük indeksi (DMFT ve dmft), TME bulguları (disfonksiyon, ağrı, ses, kısıtlı hareket), yüz karakteristikleri (mikrognati, retrognati, anterior open-bite) ve ilaç tedavileri kaydedilmiştir. Oral hijyen, 3 standart epidemiyolojik indeks (gingival index, plak indeksi ve oral temizlik indeksi) ile değerlendirilmiştir. Bulgular:Çalışma yaşları 6 ile 16 arasında değişmekte olan, 28'i (%40) erkek ve 42'si (%60) kız olmak üzere toplam 70 çocuk üzerinde yapılmıştır. Çocukların yaş ortalaması 10,28±3,49 yıldır. JIA grubu ile kontrol grubu arasında çürük açısından istatistiksel olarak anlamlı bir farklılık bulunmamaktadır. JIA grubunda kontrol grubuna göre yüksek oranda ağrı, ses ve kısıtlı hareket gözlenmiş, ancak aralarındaki fark istatistiksel olarak anlamlı bulunmamıştır. JIA grubunun gingival indeks düzeyi, kontrol grubundan istatistiksel olarak anlamlı düzeyde yüksek bulunmuştur. Sonuç:Bu sonuçlar, JIA' nın multidisipliner yönetiminde düzenli ağız-diş sağlığı hizmetinin rolünü vurgulamaktadır. Anahtar kelimeler: Jüvenil idiyopatik artrit, ağız-diş sağlığı, temporomandibular eklem SUMMARY Aim: The aim of this study was to evaluate the oral health conditions and TMJ involvement of the children diagnosed with JIA attending an education and research hospital in Istanbul and to compare them with age and gender matched healthy controls. Materials and Methods:The study included 35 children diagnosed with JIA and 35 age-and sex-matched healthy controls. In addition to demographic data, dental caries index (DMFT and DMFT), TMJ abnormalities (dysfunction, pain, voice, restricted movement), facial characteristics (micrognathia, retrognathia, anterior open bite) and used drug were recorded. Oral hygiene was assessed with 3 standard epidemiological indices (gingival index, plaque index and oral hygiene index). Results:The study was conducted on 70 children, aged between 6 to 16, 28 (%40) male and 42 (%60) female. The mean age of the children was 10.28 ± 3.49 years. There was no statistically significant difference between the JIA group and the control group in terms of caries. According to the control group, JIA group showed higher rates of pain, voice and restricted movement, but the differences between the groups were not found statistically significant. The gingival index level of the JIA group was found statistically significant-ÖZGÜN ARAŞTIRMA

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Effect of methotrexate upon antigen‐induced arthritis of the rabbit temporomandibular joint

Abstract: Systemic administration of MTX seems to have a positive effect upon the inflammatory process in the rabbit TMJ but fails to eliminate the sign of arthritis completely.

Cited by 9 publications

References 50 publications

Animal Models of Temporomandibular Disorder

Animal Models of Temporomandibular Disorder

Comprehensive Management of Rheumatic Diseases Affecting the Temporomandibular Joint

Oral health and temporomandibular joint involvement of patient with juvenile idiopathic arthritis

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