Effect of Methanolic Leaf Extract of Ficus Religiosa on Neuronal Degeneration: A Pilot Study in Male Albino Wistar Rats

Massand, Amit; Rai, Rajalakshmi; Ashwin, R.; Joy, Teresa; Murlimanju, B.V.; Marathe, Aradhana

doi:10.37506/v11/i2/2020/ijphrd/194888

Cited by 3 publications

(1 citation statement)

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“…The normal viable neurons were quantified using the imaging program NIS Elements Br version 4.30 software ( Joy et al, 2018 , Madhyastha et al, 2002 , Massand et al, 2020 ). CA1, CA2, CA3 cornu ammonis sub-regions have a length of 350 µm, and a 50-μm × 100-μm rectangle for the dentate gyrus (DG) granular layer of the hippocampus was chosen for quantification of viable neurons in each hippocampal image.…”

Section: Methodsmentioning

confidence: 99%

Effect of 2400 MHz mobile phone radiation exposure on the behavior and hippocampus morphology in Swiss mouse model

Hasan

Jahan

Islam

et al. 2022

Saudi Journal of Biological Sciences

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Section: Methodsmentioning

confidence: 99%

Effect of 2400 MHz mobile phone radiation exposure on the behavior and hippocampus morphology in Swiss mouse model

Hasan

Jahan

Islam

et al. 2022

Saudi Journal of Biological Sciences

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Mechanistic Insights into the Neuroprotective Potential of Sacred Ficus Trees

Shim

Sharma²,

An³

2022

Nutrients

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Ficus religiosa (Bo tree or sacred fig) and Ficus benghalensis (Indian banyan) are of immense spiritual and therapeutic importance. Various parts of these trees have been investigated for their antioxidant, antimicrobial, anticonvulsant, antidiabetic, anti-inflammatory, analgesic, hepatoprotective, dermoprotective, and nephroprotective properties. Previous reviews of Ficus mostly discussed traditional usages, photochemistry, and pharmacological activities, though comprehensive reviews of the neuroprotective potential of these Ficus species extracts and/or their important phytocompounds are lacking. The interesting phytocompounds from these trees include many bengalenosides, carotenoids, flavonoids (leucopelargonidin-3-O-β-d-glucopyranoside, leucopelargonidin-3-O-α-l-rhamnopyranoside, lupeol, cetyl behenate, and α-amyrin acetate), flavonols (kaempferol, quercetin, myricetin), leucocyanidin, phytosterols (bergapten, bergaptol, lanosterol, β-sitosterol, stigmasterol), terpenes (α-thujene, α-pinene, β-pinene, α-terpinene, limonene, β-ocimene, β-bourbonene, β-caryophyllene, α-trans-bergamotene, α-copaene, aromadendrene, α-humulene, alloaromadendrene, germacrene, γ-cadinene, and δ-cadinene), and diverse polyphenols (tannin, wax, saponin, leucoanthocyanin), contributing significantly to their pharmacological effects, ranging from antimicrobial action to neuroprotection. This review presents extensive mechanistic insights into the neuroprotective potential, especially important phytochemicals from F. religiosa and F. benghalensis. Owing to the complex pathophysiology of neurodegenerative disorders (NDDs), the currently existing drugs merely alleviate the symptoms. Hence, bioactive compounds with potent neuroprotective effects through a multitarget approach would be of great interest in developing pharmacophores for the treatment of NDDs.

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Comparison of Variability in duration of Aluminum-induced Neurodegeneration and Treatment with Ficus religiosa Leaf Extract in Male Wistar Rats

Massand,

Rai,

Rai

et al. 2024

Journal of the Anatomical Society of India

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Introduction: Aluminum (Al) is a known neurotoxic which is found in air, food and utensils, medicinal preparations, etc., Ficus religiosa (FR) is known as the peepal tree which is worshipped by people at large and has many medicinal importance. The objective of the study is to compare the Al groups of different durations and the treatment groups with FR leaf extract in male Wistar rats. Materials and Methods: In this study, we have taken seven groups of male albino Wistar rats, six in each. Group 1 was normal control group. Groups 2 and 3 were induced groups and Groups 4–7 are treated groups. On the last day of treatment, the brain of the animals was removed, and histology slides were prepared, and viable neurons were counted using software. For behavioral analysis, the passive avoidance test was carried out. Here, the treated Groups 4 and 5 are the groups in which the leaf extract of FR was given after treating with Al for 25 days and for Groups 6 and 7, given after treating with Al for 45 days. The comparison of different durations of the Al groups and treated groups was carried out based on neuronal count in CA3 region of hippocampus. Results: We have observed the neurodegeneration in all regions of hippocampus including dentate gyrus, but mainly, the neurodegeneration was observed in CA3 region of hippocampus. In both the parameters, there was no significant difference observed in terms of change of duration of Al (P > 0.05). The neurodegeneration observed in both Al groups was the same. The effect of treatment was observed a similar improvement in all treated groups even after in change in duration of Al (P > 0.05). Conclusion: Aluminium induced neurodegeneration in rat’s brain in both higher and lower duration and in both cases Ficus religiosa treated effectively against neurotoxicity of Al.

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Effect of Methanolic Leaf Extract of Ficus Religiosa on Neuronal Degeneration: A Pilot Study in Male Albino Wistar Rats

Cited by 3 publications

References 0 publications

Effect of 2400 MHz mobile phone radiation exposure on the behavior and hippocampus morphology in Swiss mouse model

Effect of 2400 MHz mobile phone radiation exposure on the behavior and hippocampus morphology in Swiss mouse model

Mechanistic Insights into the Neuroprotective Potential of Sacred Ficus Trees

Comparison of Variability in duration of Aluminum-induced Neurodegeneration and Treatment with Ficus religiosa Leaf Extract in Male Wistar Rats

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