Effect of Methanolic Extract of Corn Silk on Cisplatin-Induced Nephrotoxicity in Rats

Abstract

Background: Cisplatin is a cytotoxic agent in cancer therapy. Nephrotoxicity is considered as a side effect of cisplatin usage. Using rate models, we studied the possible protective impact of corn-silk (CS) extract against cisplatin-induced nephrotoxicity.Materials and Methods: Thirty-five experimental rats were divided into five groups (n=7 per each group) as follow: C1: Control received distilled water only; C2: received one dose of cisplatin, and CS: received 300 mg/kg/day of CS. Both CS1 and CS2 received 200 and 300 mg/kg/day of the CS extract orally, individually, for eight consecutive days. CS1 and CS2 received a single dose of cisplatin on the first day only. The specific biochemical markers and histopathological alterations were evaluated.Result: According to our results, cisplatin administration could have induced severe degeneration in all parts of the nephron tubules and liver. Pre-treatment with CS exhibited a significant decrease in the malondialdehyde (MDA) levels as compared to the values obtained after treatment with cisplatin alone (P<0.01). Moreover, the CS extract with 200 mg dose showed significant (P<0.01) protection against the cisplatin-induced elevation of blood urea nitrogen. Further, the serum levels of alanine transaminase and aspartate transaminase were higher in the cisplatin-treated groups, when compared to the control group (P<0.05). Furthermore, the hepatic function was also improved in cisplatin-treated animals, which were pre-treated with CS.Conclusion: CS has the potential to attenuate nephrotoxicity and lipid peroxidation induced by cisplatin in rats.[GMJ.2018;7:e1258]

Metabolite Profiling and Nephroprotective Potential of the Zea mays L. Silk Extract against Diclofenac-Induced Nephrotoxicity in Wistar Rats

“…In our study, the ZME reversed the nephrotoxicity produced by DC, which could be due to the antioxidant effect represented by modulation of MDA, GSH, CAT, SOD, and ROS levels. The obtained results are in parallel with those of the previous study conducted . The antioxidant activity of the ZME may be attributed to the bioactive compounds, mainly phenols and flavonoid present (Table ), as stated by Liu and colleagues that phenols and flavonoid are responsible for the main antioxidant activity of corn silk …”

“…The obtained results are in parallel with those of the previous study conducted. 38 The antioxidant activity of the ZME may be attributed to the bioactive compounds, mainly phenols and flavonoid present (Table 1), as stated by Liu and colleagues that phenols and flavonoid are responsible for the main antioxidant activity of corn silk. 39 Lastly, in addition to the antioxidant activity of the ZME, it also exhibits potential for maintaining the levels of IL-6, IL-1β, TNF-α, and caspase-3.…”

Effect of Corn Silk extracts on Hepatic steatosis in doxorubicin treated Albino Rats.

“…16 Corn silk extract has protective effect on hepatic tissue which is due to decreased lipid peroxidation. 17 There are some side effects of CS that should be considered, although they are rare. If someone have low or high blood pressure or abnormal potassium levels, corn silk extract could exacerbate these issues, due to its diuretic effect.…”

Effects of Experimental Hyperthyroidism on Collagen IV and Laminin-α5 Gene Expression in Balb/C Mouse Seminiferous Tubules

“…T hyroid hormones (THs) have cardinal effects on the growth and development of nearly all tissues and organs, especially the testes and process of spermatogenesis [1]. This hormone with its receptors can affect a wide range of genes.…”