Effect of Methanol Fraction of Aspidopterys indica Aerial Parts on DOCA Salt-Induced Hypertension and HR-LC-MS Assisted Phytochemical Profiling

Abstract

One reason for the growing interest in herbal medicines is the recognition that herbal medicines often contain a plethora of compounds that can have synergistic effects, offering a more holistic approach to the management of various disease conditions. 4,5 Despite the complexities involved, the ongoing exploration of plant metabolites holds great promise for discovering new bioactive compounds. Continued advancements in methodology and interdisciplinary collaboration will further enhance our understanding of the intricate chemistry of plants. Overall, the adoption of LC-MS methods for phytochemical profiling has revolutionized the study of plant metabolism, enabling researchers to explore the chemical diversity of plants in unprecedented detail. This approach holds great promise for discovering bioactive compounds with potential applications in various fields, including medicine, agriculture, and natural product research. [6][7][8][9] Aerial parts of Aspidopterys indica are traditionally used for the management of hypotensive, 10 and were reported to have potent antioxidant activity. 11 Catechin and isoorientin which are known for their antioxidant activity are among the compounds isolated from the plant. 12 There are few reports on the phytochemical studies of A. indica, thus, this comprehensive exploration can lay the foundation and provide valuable insights into the chemical composition of Aspidopterys indica and its potential role in hypertension management. Materials and Methods Plant collection and IdentificationAspidopterys indica aerial parts were collected in February 2020 from Kinnerasani Wildlife Sanctuary