Effect of methacrylated chitosan incorporated in experimental composite and adhesive on mechanical properties and biofilm formation

Stenhagen, Ida S. R.; Valen, Håkon; Dragland, Inger Sofie; Kopperud, Hilde Molvig

doi:10.1111/eos.12584

Cited by 31 publications

(26 citation statements)

References 41 publications

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“…In the present study, although no statistical difference was found in the color stability in the chitosan-modified material compared with that in the control group, a higher color stability was found in the modified material, especially after the storage in distilled water and red-wine solutions. The methacrylation of low-molecular-weight chitosan and its incorporation into the polymer network of composites and adhesives have produced stable materials after storage in water, 32 which could explain the results of the present research.…”

Section: Discussionsupporting

confidence: 70%

Color stability and surface roughness of chitosan- and nanodiamond-modified bisacrylic resin

Perchyonok¹,

Souza

Küll

et al. 2019

Braz. oral res.

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The aim of this study is to evaluate the effect of chitosan or nanodiamond incorporation on the color stability and surface roughness of a bisacrylic resin subjected to artificial aging. Four bisacrylic resins were evaluated, namely, control, chitosan-modified material, nanodiamond-modified material, and chitosan-nanodiamond-modified material. Twenty-four specimens were prepared for each material. The surface roughness was determined using a profilometer with a cutoff of 0.25 mm. The baseline color was measured according to the CIE L*a*b* system using a reflectance spectrophotometer. After these tests, the specimens were individually immersed in cola soft drink, red wine, or distilled water (n = 8) for 28 days. After the aging, the surface roughness and final color were re-evaluated. The color stability was determined using the difference between the coordinates obtained before and after the aging process. The data on roughness and color change were evaluated using ANOVA and the Tukey test (α = 0.05). The results show that the incorporation of nanodiamonds and chitosan into a bisacrylic resin provided a better color stability to the materials (p = 0.007). The storage in red wine resulted in a higher variation in the surface roughness values, especially when only the nanodiamond was incorporated to the material (p < 0.05). The incorporation of both chitosan and nanodiamonds are promising in providing an improvement in the properties of the bisacrylic resin when they are simultaneously incorporated in the product.

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Section: Discussionsupporting

confidence: 70%

Color stability and surface roughness of chitosan- and nanodiamond-modified bisacrylic resin

Perchyonok¹,

Souza

Küll

et al. 2019

Braz. oral res.

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“…Chitosan itself also has antimicrobial activities at acidic pH [221]. It could reduce biofilm formation in in vitro studies when being incorporated into resin-based composite materials [222]. Some studies also tried to successfully disrupt biofilm formation by impairing adhesion between Streptococci and Porphyromonas [223,224].…”

Section: Functionalization Of Dental Materials With Antimicrobial Activitiesmentioning

confidence: 99%

Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications

et al. 2020

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Background All soft and solid surface structures in the oral cavity are covered by the acquired pellicle followed by bacterial colonization. This applies for natural structures as well as for restorative or prosthetic materials; the adherent bacterial biofilm is associated among others with the development of caries, periodontal diseases, peri-implantitis, or denture-associated stomatitis. Accordingly, there is a considerable demand for novel materials and coatings that limit and modulate bacterial attachment and/or propagation of microorganisms. Objectives and findings The present paper depicts the current knowledge on the impact of different physicochemical surface characteristics on bioadsorption in the oral cavity. Furthermore, it was carved out which strategies were developed in dental research and general surface science to inhibit bacterial colonization and to delay biofilm formation by low-fouling or “easy-to-clean” surfaces. These include the modulation of physicochemical properties such as periodic topographies, roughness, surface free energy, or hardness. In recent years, a large emphasis was laid on micro- and nanostructured surfaces and on liquid repellent superhydrophic as well as superhydrophilic interfaces. Materials incorporating mobile or bound nanoparticles promoting bacteriostatic or bacteriotoxic properties were also used. Recently, chemically textured interfaces gained increasing interest and could represent promising solutions for innovative antibioadhesion interfaces. Due to the unique conditions in the oral cavity, mainly in vivo or in situ studies were considered in the review. Conclusion Despite many promising approaches for modulation of biofilm formation in the oral cavity, the ubiquitous phenomenon of bioadsorption and adhesion pellicle formation in the challenging oral milieu masks surface properties and therewith hampers low-fouling strategies. Clinical relevance Improved dental materials and surface coatings with easy-to-clean properties have the potential to improve oral health, but extensive and systematic research is required in this field to develop biocompatible and effective substances.

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“…There have been many attempts to develop new bio-stable and antidegradation immobilized antimicrobial agents [ 98 , 99 , 100 , 101 ]. The nanoassemblies formed by Fmoc-pentafluoro-l-phenylalanine-OH (Fmoc-F5-Phe) have been functionally incorporated within resin-based composites.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

“…Several studies have modified antimicrobial agents, for example, by connecting them to a methacrylate monomer, so that they can be added to the crosslinked network of the resin composite [ 99 , 100 ]. A triclosan methacrylate (TM) monomer was developed and incorporated into an experimental resin composite.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

“…Stenhagen et al prepared methacrylated chitosan (CH-MA) for incorporation into dental composites. While it reduced biofilm formation on resin-based composites’ surfaces, it posed challenges to the mechanical properties of the resin [ 100 ]. Because of the rapid release of silver ions and possible biological toxicity, Srivastava and Sun covalently immobilized silver sulfadiazine onto glass fillers and used them in dental restorative formulas.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

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Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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Effect of methacrylated chitosan incorporated in experimental composite and adhesive on mechanical properties and biofilm formation

Cited by 31 publications

References 41 publications

Color stability and surface roughness of chitosan- and nanodiamond-modified bisacrylic resin

Color stability and surface roughness of chitosan- and nanodiamond-modified bisacrylic resin

Bioadhesion in the oral cavity and approaches for biofilm management by surface modifications

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

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