Effect of Metformin on Hormonal and Biochemical Profile in PCOS Before and After Therapy

Singh, Bratati; Panda, Suchismita; Nanda, Rachita; Pati, Sanghamitra; Mangaraj, Manaswini; Sahu, Pratima Kumari; Mohapatra, Prakash Chandra

doi:10.1007/s12291-010-0090-2

Cited by 16 publications

(13 citation statements)

References 23 publications

(30 reference statements)

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“…15 The hormones show a rise of serum insulin and testosterone in PCOS cases when compared to control (p<0.001), indicating the role of hyperinsulinemia in the pathogenesis of PCOS. 16,17 A significantly higher (p<0.001) mean PSA levels of cases were observed than the control group which was in similar with the observations of Melegos et al and Gullu et al, confirming that PCOS, a hyperandrogenemic disease is likely to be present with high levels of PSA. 18,19 Taking the fasting glucose to insulin ratio of ≤4.5 as insulin resistance, 62% of cases and 8.3% of controls were considered as insulin resistant.…”

Section: Resultssupporting

confidence: 88%

“…22 Insulin resistance also reduced from 75.62% of cases to 42.3% after therapy, which was in concurrence with the studies that metformin exert its effects by encouraging peripheral glucose utilisation. 16,23 When we studied the effect of metformin on PSA level, no significant change was observed in our group of patients. Jonathan L, et al demonstrated a decrease in PSA level in their group of prostate cancer patients after metformin therapy.…”

Section: Resultsmentioning

confidence: 66%

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Role of insulin sensitising agents in altering PSA level in PCOS

Panigrahy

Singh

Pattnaik

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Ovarian androgen production can be promoted by insulin resistance which leads to reproductive abnormalities in Polycystic Ovarian Syndrome (PCOS). A wide variety of female tissues can synthesize and secrete Prostate Specific Antigen (PSA). Androgens may take part a significant role in PSA secretion in PCOS. As insulin resistance stimulates androgen production, the baseline value of PSA may decline by insulin sensitising agents in PCOS. Present study is an attempt to measure the function of PSA as a marker of androgen excess in PCOS and to assess the role of insulin sensitising agent metformin in altering PSA level in PCOS.Methods: The study was undertaken to assess the insulin resistance, testosterone and PSA level in 45 women diagnosed as PCOS and 45 healthy controls. Alteration of insulin resistance, serum testosterone and PSA levels by metformin was also analysed.Results: A significant increase in testosterone, PSA level and insulin resistance was observed in PCOS cases when compared with control (p<0.001). When metformin was given for 4 months, improvement in insulin resistance and testosterone level was found in cases, but PSA values observed no change. Correlation was not found linking insulin resistance with PSA level prior to and after therapy.Conclusions: Serum PSA level could be detected in high significant concentration in PCOS women. Various researches explain that insulin resistance and BMI may perhaps control serum PSA level, but our result demonstrate no effect of insulin sensitising agent on serum PSA value.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 66%

Role of insulin sensitising agents in altering PSA level in PCOS

Panigrahy

Singh

Pattnaik

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…Affecting up to 75% of PCOS patients (29), HA may be the major factor in development of IR in PCOS patients. A positive correlation between serum testosterone level and insulin level has been observed in women with PCOS (37). Insulin resistance was associated with decreased basal metabolic rate in women with PCOS and HA (38).…”

Section: Discussionmentioning

confidence: 94%

Increased mean glucose levels in patients with polycystic ovary syndrome and hyperandrogenemia as determined by continuous glucose monitoring

Zhu

Teng

Zhou

et al. 2012

Acta Obstet Gynecol Scand

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“…Our study showed that, non-obese PCOS patients presented with increased body iron stores and a marked increase in hormones insulin and testosterone which are in agreement with other workers. [13][14][15][16] Marked rise in serum total testosterone in these cases may be due to excess ovarian production of androgens, which is central to the diagnosis of PCOS. 17 Yet some researchers have shown apparently normal testosterone concentrations in their PCOS cases, which may be attributed to their low to normal sex hormone binding globulin levels.…”

Section: Associations Between Ferritin and Hormonesmentioning

confidence: 99%

Body iron status and association with hyperinsulinaemia and hyperandrogenism in non-obese Indian women with polycystic ovarian syndrome

Supriya¹,

Bitla²,

Prasad³

et al. 2012

JCSR

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Background: Increased body iron stores, insulin and androgen levels have been reported in obese women with polycystic ovarian syndrome (PCOS). However, the status of iron and the influence of hormonal profile on iron status in non-obese women with PCOS has not been studied. The present study was thus designed to determine the iron status and hormones insulin and testosterone levels and their association with body iron status in non-obese women patients with PCOS. Methods: The present study included 33 non-obese women diagnosed as PCOS based on National Institutes of Health consensus 1990 criteria and 31 age-matched healthy women as controls. Height, weight, body mass index, fasting plasma glucose, iron status markers i.e., serum ferritin, iron, total iron binding capacity, insulin and testosterone levels were determined. Results: A significant increase in hormones insulin and testosterone levels (p<0.001) was found in patients with PCOS in comparison with controls. Similarly, a significant increase in serum ferritin levels was observed in PCOS patients compared to controls (p<0.05). A significant positive correlation was observed between serum insulin and testosterone levels (p<0.05). Similarly, a positive association was observed between serum testosterone and ferritin levels [p=0.007 odds ratio (OR) 7.0(1.715-28.568)]. Conclusions: The present study demonstrates that body iron stores, as reflected by serum ferritin concentrations, are increased even in non-obese PCOS patients. Androgen excess is associated with increased body iron stores in these patients with the possible additive effects of hyperinsulinaemia, through its perpetuating effect on increased androgens and iron-sparing effect of reduced menstrual losses.

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Effect of Metformin on Hormonal and Biochemical Profile in PCOS Before and After Therapy

Cited by 16 publications

References 23 publications

Role of insulin sensitising agents in altering PSA level in PCOS

Role of insulin sensitising agents in altering PSA level in PCOS

Increased mean glucose levels in patients with polycystic ovary syndrome and hyperandrogenemia as determined by continuous glucose monitoring

Body iron status and association with hyperinsulinaemia and hyperandrogenism in non-obese Indian women with polycystic ovarian syndrome

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