Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components on the Prevalence and Severity of Angiographic Coronary Artery Disease

Gui, Minghui; Ling, Yan; Liu, Lin; Jiang, Jingjing; Li, Xiaoying; Gao, Xin

doi:10.4103/0366-6999.201611

Cited by 21 publications

(34 citation statements)

References 30 publications

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“…In a lipid glucose study conducted in Tehran, significant associations between BMI and various types of dyslipidemia were observed; however, WHR only maintained a significant association with hypertriglyceridemia and low HDL-C.[ 36 37 ] In China, increased BMI was found to be associated with increased TC and TG, and a negative association was ascertained between HDL and BMI. [ 38 ] We found that there were significant correlations between BMI and lipid levels (LDL-C, HDL-C, TC, and TG), and when compared with the normal weight group, as defined by BMI, the odds of dyslipidemia in the overweight and obese groups were 2.60 and 3.59 times greater, respectively.…”

Section: Discussionmentioning

confidence: 89%

Associations between Body Composition Indices and Metabolic Disorders in Chinese Adults

Zhang

Dong²,

Wang

et al. 2018

Chinese Medical Journal

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Background:Obesity induces dyslipidemia, hypertension, glucose intolerance, and inflammatory state, which results in atherogenic processes, diabetes, and cardiovascular disease. We usually use body composition indices, such as body mass index (BMI), body fat percentage (BFP), waist circumference-height ratio (WHtR), and waist-hip ratio (WHR) to reflect the obesity. The aim of this large population-based cross-sectional study was to investigate the associations between body composition indices and metabolic parameters in Chinese adults.Methods:A total of 12,018 Chinese adults were included. Body composition indices, such as BMI, BFP, WHtR, and WHR, and metabolic parameters, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), fasting blood glucose (FBG), 2 h postprandial blood glucose (2h PBG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS), insulin resistance index (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), and white blood cell count (WBC), were measured and analyzed. All analyses were stratified by gender.Results:All body composition indices and metabolic parameters except 2h PBG differed significantly between males and females (all P < 0.001). BMI was positively associated with SBP, DBP, LDL-C, TC, TG, FBG, 2h PBG, HbA1c, FINS, HOMA-IR, hs-CRP, and WBC, and inversely associated with HDL-C; similar relationships were identified between the metabolic parameters and BFP, WHtR, and WHR. In the multivariate analysis, the odds of impaired glucose regulation, dyslipidemia, insulin resistance, and increased hs-CRP were 1.36, 1.92, 3.44, and 1.27 times greater in the overweight group than those in the normal weight group, respectively, and 1.66, 3.26, 7.53, and 1.70 times greater in the obese group than those in the normal weight group, respectively. The odds of dyslipidemia and hs-CRP were 1.29 and 1.38 times greater in the BFP ≥28.0% group than in the BFP <28.0% group, respectively. The odds of dyslipidemia, HOMA-IR, and hs-CRP were 1.55, 1.26, and 1.48 times greater in the WHtR ≥0.96 group than in the WHtR <0.96 group, respectively. Among males, the odds of HOMA-IR were 1.46 times greater in the WHR ≥0.54 group than in the WHR <0.54 group. Similar results were observed in females.Conclusions:This study identified positive associations between all evaluated body composition indices and metabolic parameters in Chinese adults. Among the body composition indices, BMI predicted four of the five evaluated metabolic disorders in both gender groups.

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Section: Discussionmentioning

confidence: 89%

Associations between Body Composition Indices and Metabolic Disorders in Chinese Adults

Zhang

Dong²,

Wang

et al. 2018

Chinese Medical Journal

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“…We previously reported that the prevalence of MetS in the United States was 33•6% in the adult population [4]. MetS predicts the development of diabetes [5] and hypertension [6], and is also associated with coronary artery disease (CAD) [7] and increased mortality [8].…”

Section: Introductionmentioning

confidence: 99%

“…However, China is a multi-ethnic country with at least 55 ethnic groups. There are few studies focused on MetS among different ethnic groups in China, and most of these studies focused on a single ethnic group [7,12,13]. The heterogeneity in study design, inclusion criteria and definition of MetS makes it difficult to compare the prevalence in different ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of metabolic syndrome among ethnic groups in China

et al. 2020

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Background: Metabolic syndrome (MetS) is common in China, which has a multi-ethnic population of 1•3 billion. We set out to determine the prevalence of MetS and its components in different ethnic groups. Methods: This nationwide cross-sectional survey involved 24,796 participants from eight ethnicities in six provinces in China from 2008 to 2011. MetS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Results were analysed using SPSS version 22•0 in 2018. Logistic regression was used for deriving odds ratios and 95% confidence intervals of risk factors for the MetS. Results: The prevalence of MetS increased with age from 3•60% to 21•68%. After age standardization, the prevalence of MetS, in descending order, was 35•42% (Korean), 22•82% (Hui), 19•80% (Han), 13•72% (Miao), 12•90% (Tujia), 12•04% (Li), 11•61% (Mongolian), 6•17% (Tibetan). Korean ethnicity was associated with a higher prevalence in five components of MetS, while Tibetan ethnicity was associated with lower prevalence except decreased HDL cholesterol. Logistic regression analyses showed that age, drinking and being non-Tibetan were associated with a higher risk of MetS. Conclusions: Within one country, albeit a large one, the prevalence of MetS can vary greatly. Chinese of Korean ethnicity had a much higher prevalence than Tibetan ethnicity. Measures to tackle MetS should be tailored to the ethnic groups within a population.

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“…[ 1 ] MetS is considered as a risk factor for cardiovascular disease (CVD). The presence of MetS leads to a threefold increase in CVD risk[ 2 ] and contributes to all-cause mortality. [ 3 ] The study has reported that EH was one of the key features of MetS,[ 4 ] and the presence of MetS in EH patients was higher than in the general population.…”

Section: Introductionmentioning

confidence: 99%

Astragalus Membranaceus Improving Asymptomatic Left Ventricular Diastolic Dysfunction in Postmenopausal Hypertensive Women with Metabolic Syndrome

et al. 2018

Chinese Medical Journal

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Background:Postmenopausal women with metabolic syndrome (MetS) have increased cardiovascular morbidity and left ventricular diastolic dysfunction (LVDD). The various protective effects of astragalus membranaceus (AM) have been described in previous studies. Therefore, this study aimed to evaluate the effects of different doses of AM on diastolic function in postmenopausal hypertensive women with MetS.Methods:This was a prospective, randomized controlled study. The postmenopausal hypertensive patients with MetS were enrolled from Lanzhou University Second Hospital from March 2014 to April 2015. Patients were divided into three groups: control group (received conventional medical treatment), AM Group 1 (received AM capsules at 5 g/d additionally), and AM Group 2 (received AM capsules at 10 g/d additionally). Echocardiographic and clinical characteristics were evaluated before and 12 months after treatment. Quantitative data were analyzed using unpaired t-test, analysis of variance, and multiple linear regression analysis.Results:A total of 154 patients were subjected to final analysis. In the AM Group 2, significant improvements were noted in diastolic function 12 months after treatment than those of the control group, including the early diastolic mitral annular velocity (E’; 0.065 ± 0.007 m/s vs. 0.061 ± 0.008 m/s, P = 0.014), the ratio of the early diastolic mitral peak flow velocity to the late diastolic mitral peak flow velocity (E/A; 0.81 ± 0.05 vs. 0.80 ± 0.06, P = 0.012), the ratio of E’ to the late diastolic mitral annular velocity (E’/A’; 0.56 ± 0.12 vs. 0.51 ± 0.13, P = 0.048), and the ratio of the early diastolic mitral peak flow velocity (E) to E’ (E/E’; 10.70 ± 1.30 vs. 11.37 ± 1.73, P = 0.031). After treatment, E/E’ (10.70 ± 1.30 vs. 11.24 ± 1.56, P = 0.021), deceleration time (DT; 261.49 ± 44.41 ms vs. 268.74 ± 53.87 ms, P = 0.046), and E’/A’ (0.56 ± 0.12 vs. 0.52 ± 0.13, P = 0.019) values improved more significantly than those of AM Group 2 before treatment. Besides, waist circumference was positively correlated with E’ (r = 0.472; P = 0.003) and E’/A’ (r = 0.321; P = 0.047). In addition, the waist-to-hip ratio was a significant predictor of DT (r = 0.276; P = 0.041), E’ (r = −0.590; P < 0.001), E/E’ (r = 0.454; P = 0.004), and E’/A’ (r = −0.377; P = 0.018).Conclusions:Conventional medical plus AM therapy improved diastolic function. Moreover, WC and WHR might be risk factors for LVDD.Chinese Clinical Trial Register:ChiCTR-TRC-11001747. http://www.chictr.org.cn/showprojen.aspx?proj=7798.

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Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components on the Prevalence and Severity of Angiographic Coronary Artery Disease

Cited by 21 publications

References 30 publications

Associations between Body Composition Indices and Metabolic Disorders in Chinese Adults

Associations between Body Composition Indices and Metabolic Disorders in Chinese Adults

Prevalence of metabolic syndrome among ethnic groups in China

Astragalus Membranaceus Improving Asymptomatic Left Ventricular Diastolic Dysfunction in Postmenopausal Hypertensive Women with Metabolic Syndrome

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