Effect of metabolic syndrome components and their clustering on carotid atherosclerosis in a sample of the general Japanese population

Abstract

The objective of this study was to investigate the impact of metabolic syndrome (MS) on carotid atherosclerosis in a Japanese population. A total of 1727 subjects (805 males and 922 females) were included. Intima-media thickness (IMT) was measured using ultrasonography. To evaluate the independent determinants of IMT, a stepwise multiple regression analysis was employed that included age, current smoking habit, LDL-C, HbA1c and the MS components (SBP, DBP, TG, HDL-C, FBG, and WC) as independent variables. Multivariate regression analyses were performed to determine the independent associations of the MS components with IMT. In males, age (β=0.383, P<0.001), SBP (β=0.237, P<0.001), LDL-C (β=0.188, P<0.001), current smoking habit (β=0.124, P=0.007) and HbA1c (β=0.110, P=0.014) were significantly associated with IMT. In females, age (β=0.474, P<0.001), SBP (β=0.130, P=0.003) and FBG (β=0.110, P=0.038) were significantly associated with IMT. The present study demonstrated that an elevated number of MS components, with or without central obesity, is associated with higher IMT. Among the analyzed components, hypertension has the strongest association with higher IMT.

The Level of Intima-Media Thickness in Patients with Metabolic Syndrome in Poland Depending on the Prevalence of Type 2 Diabetes

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Job stress and behavioral characteristics in relation to coronary heart disease risk among Japanese police officers

“…However, according to the criterion of Japan-specific metabolic syndrome 33 ) , a person who does not have abdominal obesity is not diagnosed with metabolic syndrome even if he/she has all of the metabolic abnormalities. In this regards, some recent reports including our study have revealed that a clustering of the metabolic abnormalities is crucial irrespective of the presence or absence of abdominal obesity 38 , 39 , 40 ) . We, therefore, attempted to estimate the individual risk profile for CHD by assessing a clustering number of hypertension, dyslipidemia, glucose intolerance and hyperuricemia except for abdominal obesity.…”

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“…, 30 Elshorbagy et al 31 identified a significant increase in carotid intima-media thickness in metabolic syndrome patients as compared to the non-metabolic syndrome obese and control groups. Hirata et al 32 demonstrated in a study, which included 1727 subjects, that an elevated number of metabolic syndrome components, with or without central obesity, was associated with higher intima-media thickness and, hypertension had the strongest association with higher intima-media thickness. Alp et al 33 found that carotid artery intima-media thickness was strongly associated with Tei index values.…”