Effect of Metabolic Acidosis on Hydrogen Ion Excretion in a Pigtail Macaque with Erythrocyte Carbonic Anhydrase I Deficiency

Abstract

Metabolic acidosis was induced by NHICl ingestion in a normal pigtail macaque (Macaca nemestrina) and a pigtail macaque with an inherited deficiency of red cell carbonic anhydrase I (CA I). After this acid stress, both the normal and CA I-deficient animals were able to acidify their urine, and displayed similar hydrogen ion clearance indexes. These findings suggest that a defective red cell CA I, reported in some cases of renal tubular acidosis in humans, is not directly responsible for the impairment of bicarbonate reabsorption in the kidney tubules. Downloaded from U r m m m z cl 4 9 z U x+ m x c) rn m =! 0 z at University of Tokyo on June 13, 2015 ebm.sagepub.com Downloaded from