Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis

Yigitler, Cengizhan; Güleç, Bülent; Aydoğan, Hakan; Özcan, Ayhan; Kılınç, Metin; Yiğit, Taner; Kozak, Orhan; Pekcan, Mesut

doi:10.1111/j.1440-1746.2004.03457.x

Cited by 4 publications

(2 citation statements)

References 41 publications

(79 reference statements)

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“…a: contrast-enhanced CT scan in the axial plane obtained during the arterial phase shows large RAML with arterial dysplasia (white arrow); b: early phase renal angiography of large RAML in the lower pole of a right kidney with arterial dysplasia (white arrow); c: early phase renal angiography: embolization with coils and microspheres of large RAML with arterial dysplasia (black arrow); d: contrastenhanced CT scan in the nephrographic phase shows RAML necrosis following embolization with coils and microspheres of a large RAML with arterial dysplasia and a fatty fluid layer (white arrow); e: contrast-enhanced CT scan in the axial plane shows 90% reduction in RAML volume 12 months after arterial embolization (white arrow). arterial dysplasia, multifocal vessel anomalies, high-risk locations (subcapsular or exorenal locations), a history of bleeding and the hormonal setting (pregnancy, childbirth) [7,11,13,22,23].…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis after preventive embolization of large renal angiomyolipomas

Rafei

Renard

Puech

et al. 2015

Diagnostic and Interventional Imaging

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Section: Discussionmentioning

confidence: 99%

Tumor necrosis after preventive embolization of large renal angiomyolipomas

Rafei

Renard

Puech

et al. 2015

Diagnostic and Interventional Imaging

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“…Changing the microbial mass or composition using antibiotics (particularly Metronidazole and Ciprofloxacin) has been effective for treating some Crohn's and UC patients, as well as IBD patients with septic complications [10,30]. Ciprofloxacin, Vancomycin-imipenem, and Amoxicillin/clavulanic acid have been shown to decrease inflammation in TNBS-induced colitis [33,34], while a combination of Metronidazole and Gentamicin is effective in reducing the number of translocated bacteria in acetic-acid induced colitis [35]. In mouse and rat studies, antibiotics have been successfully used to prevent the colitis that spontaneously develops in IL-10 deficient mice [13], to decrease the inflammation in DSS-induced colitis [36], to treat transgenic HLA-B27-related colitis [31], and to attenuate acetic acid colitis in mice [37].…”

Section: Antibiotic Treatment and Gut Barrier Dysfunctionmentioning

confidence: 99%

Gut sterilization in experimental colitis leukocyte mediated colon injury, and effects on angiogenesis/lymphangiogenesis

Patel¹,

Olinde²,

Tatum³

et al. 2013

OJGas

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Inappropriate responses to normal commensal bacteria trigger immune activation in both inflammatory bowel disease and experimental colitis. How gut flora contribute to the pathogenesis of inflammatory bowel disease is unclear, but may involve entrapment of leukocytes and remodeling of the vascular system. Here we evaluated how the progression and tissue remodeling in experimental colitis differ in a germ- free model of mouse colitis. Four treatment groups were used: control, antibiotic-treated (ABX), dextran sulfate colitis (DSS) and DSS pre- and co-treated with antibiotics (DSS + ABX). In days 0 - 3 of the study, germ-free mice received antibiotics (vancomycin, neomycin, and metronidazole). During the next 11 days, antibiotics were continued and DSS (3%) added to “colitis” groups. Disease activity, weight, stool form and blood were monitored daily. Mice were sacrificed and tissue samples harvested. Histopathological scores in controls (0.00) and in ABX (1.0+/–0.81) were significantly (p < 0.001) lower than DSS (12+/–0). Extents of injury, inflammation and crypt damage were all improved in DSS + ABX. The Disease Activity Index score (day 11) was significantly worse in the DSS group compared to the DSS + ABX group. Stool blood and form scores were also significantly improved among these groups. Importantly, myeloper- oxidase was significantly reduced in DSS + ABX, indicating that neutrophil infiltration was blocked. Colitis was associated with an increase in blood and lymphatic vessels; both of these events were also significantly reduced by gut sterilization. Our experiment shows that clinical and histopathological severity of colitis was significantly worse in the DSS colitis group compared to the DSS + ABX group, supporting the hypothesis that development of IBD is likely to be less severe with appropriate antibiotic treatment. In particular, gut sterilization effectively reduces leuko- cyte-dependent (PMN) injury to improve outcomes and may be an important target for therapy.

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Goat Milk Oligosaccharides Are Anti-Inflammatory in Rats with Hapten-Induced Colitis

Daddaoua

Puerta

Requena

et al. 2006

The Journal of Nutrition

116

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Oligosaccharides are included among the anti-inflammatory components of milk because of their prebiotic properties and their capacity to act as receptors of microorganisms. Here the intestinal anti-inflammatory effect of goat milk oligosaccharides (O) was assessed in trinitrobenzenesulfonic (T) acid-induced colitis in rats. Rats were randomly assigned to three different groups. Two groups (T and OS) of colitic rats and a control group (C) were studied. Group OS received 500 mg/(kg.d) of goat milk oligosaccharides orally, starting 2 d before the colitis induction until d 6, and groups T and C received the vehicle. When compared with the T group, the OS group showed decreased anorexia and body weight loss; reduced bowel wall thickening and longitudinal extension of necrotic lesions; downregulated colonic expression of interleukin 1beta, inducible nitric oxide synthase, cyclooxygenase 2, and mucin 3; and increased trefoil factor 3. Thus, goat milk oligosaccharides have anti-inflammatory effects in rats with experimental colitis and may be useful in the management of inflammatory bowel disease.

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Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis

Cited by 4 publications

References 41 publications

Tumor necrosis after preventive embolization of large renal angiomyolipomas

Tumor necrosis after preventive embolization of large renal angiomyolipomas

Gut sterilization in experimental colitis leukocyte mediated colon injury, and effects on angiogenesis/lymphangiogenesis

Goat Milk Oligosaccharides Are Anti-Inflammatory in Rats with Hapten-Induced Colitis

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